exoc3
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  • Official Full Name
  • exocyst complex component 3
  • Background
  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
  • Synonyms
  • EXOC3; exocyst complex component 3; SEC6 like 1 (S. cerevisiae) , SEC6L1; Sec6p; EXOC 3; Exocyst complex component Sec 6; Exocyst complex component Sec6; rSec 6; Sec 6; Sec 6 homolog; Sec 6p; Sec6; SEC6 L1; SEC6 like 1; Sec6 protein; SEC6L1; SEC6-like 1
Cat.#:EXOC3-220HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EXOC3 Protein, His-tagged
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Cat.#:EXOC3-3556HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EXOC3 Protein, GST-tagged
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Cat.#:Exoc3-221RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Exoc3 Protein, His-tagged
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Cat.#:EXOC3-12586HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EXOC3, GST-tagged
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Cat.#:EXOC3-5370MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse EXOC3 Protein
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Cat.#:EXOC3-2166RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat EXOC3 Protein
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Cat.#:EXOC3-1517RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EXOC3 Protein, His-tagged
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Cat.#:EXOC3-1526CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EXOC3
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Cat.#:EXOC3-11989ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EXOC3
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Cat.#:EXOC3-6512HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human EXOC3 293 Cell Lysate
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Involved Pathway

EXOC3 involved in several pathways and played different roles in them. We selected most pathways EXOC3 participated on our site, such as Arf6 trafficking events, Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arf6 trafficking events
CTNND1; SPAG9; ADRB2; EDNRB; CLTC; PTBP3; CTNNA1; EXOC3; EXOC1; CHRM2
Assembly of the primary cilium
TTC30A1; TUBB4B; MAPRE1; SSNA1; TTC21B; KIFAP3; CYS1; CKAP5; SCLT1; RABL5
Cargo trafficking to the periciliary membrane
EXOC6; ARL3; EXOC3; SSTR3; SETD6; CCT2; CYS1; TCP1; BBS12; EXOC5
Insulin Pathway
EXOC6; DOK1; EXOC1; GRB10; GRB14; EXOC3; EXOC5
Insulin processing
CPN1; EXOC6; SLC30A6; KIF5B; EXOC8; KIF5A; RAB27A; PCSK2; SLC30A5; EXOC3
Membrane Trafficking
GJB7; RAB10; YKT6; TRAPPC6B; MYO6; CNIH; TBC1D8B; PPP6C; HIP1R; AP1S3A
Metabolism of proteins
TBCE; TIMM21; CMA1; CHCHD4; PROCA; NAPB; PPP6R3; TGFBI; IGFBP5; C8orf84
Organelle biogenesis and maintenance
RAB3IP; TTC21B; TFB2M; BBS10; MRRF; ARL13B; MRPL48; EXOC5; SCLT1; BBS2

Protein Function

EXOC3 has several biochemical functions, for example, SNARE binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC3 itself. We selected most functions EXOC3 had, and list some proteins which have the same functions with EXOC3. You can find most of the proteins on our site.
Function
Related Protein
Function SNARE binding
Related Protein GOSR1; STX7; VTI1B; STX11B.2; SEC22A; GOSR2; SEC22C; VAMP3; MYO5A; VAMP5
Function protein binding
Related Protein FOXG1; ARHGEF4; TDRKH; SREBF2; LAMP1; TNF; ESRRG; SNX17; GNB1B; HIST1H2BE

Interacting Protein

EXOC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC3.
EGFR; MYC; LAPTM4B; Poc1b; BUB3; MLH1; dedA3; pi3p; Birc6; SNW1