fam175a
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  • Official Full Name
  • family with sequence similarity 175, member A
  • Background
  • Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
  • Synonyms
  • FAM175A; family with sequence similarity 175, member A; ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98;
Cat.#:FAM175A-5536MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FAM175A Protein
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Cat.#:FAM175A-2227RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FAM175A Protein
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Cat.#:FAM175A-2816CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FAM175A
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Cat.#:FAM175A-1517ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FAM175A
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Involved Pathway

FAM175A involved in several pathways and played different roles in them. We selected most pathways FAM175A participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAM175A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
TCTN2; MAD2L1; ANKLE2; MIS18A; INCENP; RAD1; WAPAL; E2F6; ABL1; BANF1
Cell Cycle Checkpoints
MCM8; BABAM1; CHEK2; CDKN1B; KAT5; CDK2; HTATIP; UBE2V2; HIST3H2BB; RAD17
DNA Double Strand Break Response
TP53BP1; UIMC1; BARD1; RAD50; EYA2; RNF168; UBE2V2; THRSP; BAZ1B; BRCC3
DNA Double-Strand Break Repair
UIMC1; FAM175A; KIAA0146; GEN1; RNF168; DNA2; TP53BP1; POLD3; EYA3; TDP2
DNA Repair
BARD1; INO80; POLI; USP43A; WRN; KIAA0146; DDB2; PIAS3; ZNF830; MAD2L2
G2/M Checkpoints
RAD9; BRE; TP53BP1; BABAM1; RAD17; BRCC3; RNF168; FAM175A; RAD9A; RAD1
G2/M DNA damage checkpoint
BRE; BARD1; BABAM1; FAM175A; UIMC1; BRCC3; THRSP; TP53BP1; RNF168
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
RTEL1; RNF4; TIMELESS; WRN; THRSP; RBBP8; RNF168; FUZ; BABAM1; HUS1

Protein Function

FAM175A has several biochemical functions, for example, polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAM175A itself. We selected most functions FAM175A had, and list some proteins which have the same functions with FAM175A. You can find most of the proteins on our site.
Function
Related Protein
Function polyubiquitin binding
Related Protein PSMD4A; DNAJB2; PSMD4B; AGL; DZIP3; BRE; SHARPIN; THRSP; TNIP2; FAM175A

FAM175A Related Articles

Carpena, X; Switala, J; et al. Crystallization and preliminary X-ray analysis of the catalase-peroxidase KatG from Burkholderia pseudomallei. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58:2184-2186(2002).
Park, H; Kim, SI; et al. Characterization and classification of five cysteine proteinases expressed by Paragonimus westermani adult worm. EXPERIMENTAL PARASITOLOGY 102:143-149(2002).