FAM175A Protein, family with sequence similarity 175, member A

FAM175A

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FAM175A

Official Full Name family with sequence similarity 175, member A
Background Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Synonyms FAM175A; family with sequence similarity 175, member A; ABRA1; CCDC98; BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98;
    • Species :
    • Chicken
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse FAM175A-5536M Recombinant Mouse FAM175A Protein Mammalian Cell His
    Rat FAM175A-2227R Recombinant Rat FAM175A Protein Mammalian Cell His
    Chicken FAM175A-2816C Recombinant Chicken FAM175A Mammalian Cell His
    Zebrafish FAM175A-1517Z Recombinant Zebrafish FAM175A Mammalian Cell His

    FAM175A involved in several pathways and played different roles in them. We selected most pathways FAM175A participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAM175A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle TGFB1A; ORC6L; NDEL1; CCND1; ORC5; LIN37; CSNK1D; CTDNEP1B; NDEL1A; ESCO2
    Cell Cycle Checkpoints BABAM1; CDKN1B; HIST4H4; KAT5; UBE2V2; BARD1; CDK2; DBF4; MCM10; CHEK2
    DNA Double Strand Break Response BARD1; RNF168; BABAM1; EYA2; KDM4B; TP53BP1; EYA3; THRSP; BAZ1B; HTATIP
    DNA Double-Strand Break Repair RTEL1; SMARCA5; PPP4R2; UBE2V2; RAD1; RAD9A; RBBP8; RAD51AP1; BRCC3; RAD9B
    DNA Repair PPP4R2; ACTR5; RNF4; DCLRE1A; COPS3; RAD1; KIAA0101; KDM4A; BRCC3; MCRS1
    G2/M Checkpoints RAD1; RAD17; BRCC3; UIMC1; RAD9; RNF168; FAM175A; BABAM1; THRSP; BRE
    G2/M DNA damage checkpoint TP53BP1; FAM175A; BRCC3; UIMC1; THRSP; BABAM1; BARD1; BRE; RNF168
    HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) PPP4R2; PPP4R2B; THRSP; TIPIN; EME1; TP53BP1; TOPBP1; RHNO1; RAD9; BABAM1

    FAM175A has several biochemical functions, for example, polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAM175A itself. We selected most functions FAM175A had, and list some proteins which have the same functions with FAM175A. You can find most of the proteins on our site.

    Function Related Protein
    polyubiquitin binding DZIP3; ZFAND6; RAD18; RAD23A; PSMD4A; TNIP2; VCP; BRCC3; BRE; SHARPIN

    FAM175A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAM175A here. Most of them are supplied by our site. Hope this information will be useful for your research of FAM175A.

    Carpena, X; Switala, J; et al. Crystallization and preliminary X-ray analysis of the catalase-peroxidase KatG from Burkholderia pseudomallei. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58:2184-2186(2002).
    Park, H; Kim, SI; et al. Characterization and classification of five cysteine proteinases expressed by Paragonimus westermani adult worm. EXPERIMENTAL PARASITOLOGY 102:143-149(2002).

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