foxh1
Share
  • Official Full Name
  • forkhead box H1
  • Background
  • Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.
  • Synonyms
  • FOXH1; forkhead box H1; forkhead box protein H1; FAST 1; Fast 2; Fast-1; Fast-2; FAST1; Fast2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; FOX H1; FOXH 1; FOXH1_HUMAN; hFAST 1; hFAST-1; hFAST1; Human homolog of Xenopus forkhead activin signal transducer 1; TGF beta/Activin signal transducer FAST1
Cat.#:FOXH1-2562HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOXH1 Protein, His-tagged
+Inquiry
Cat.#:FOXH1-5991MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FOXH1 Protein
+Inquiry
Cat.#:FOXH1-9052ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FOXH1
+Inquiry
Cat.#:FOXH1-6156HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FOXH1 293 Cell Lysate
+Inquiry

Involved Pathway

FOXH1 involved in several pathways and played different roles in them. We selected most pathways FOXH1 participated on our site, such as Developmental Biology, Heart Development, Regulation of nuclear SMAD2/3 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
PEA15A; GDNF; DPYSL4; SCN2A; EFNA2; ARPC2; EFNB3B; ARHGEF28; EFNA5; MED18
Heart Development
SMYD1; FOXH1; BMP10; HEY2; FOXC2; NKX2-5; NKX2; HEY1; GATA6; TBX5
Regulation of nuclear SMAD2/3 signaling
CBFB; NKX2; MYOD1; SKI; SNIP1; FOXH1; CITED1; GSC
Signal Transduction
MLN; PTHLH; DEPDC1B; ARHGAP40; FAM105B; MDK; NRP2; RBP3; RHOUA; TULP3
Signaling by Activin
FOXH1; FSTL3; FST; INHBAA; FSTB; DRAP1; ACVR1C
Signaling by NODAL
PCSK6; TDGF1; LEFTY1; ACVR1C; DRAP1; GDF1; CFC1; FOXH1
TGF Beta Signaling Pathway
FOXH1; ZNF423; FST; TGFBR3; NOG; ZFP423; ENG; RUNX3; LEFTY1
TGF-beta Receptor Signaling Pathway
ZEB2A; STAMBPL1; CTCF; ACVRL1; ZEB1B; EID2; TGFBR3; SNIP1; STRAP; DAB2

Protein Function

FOXH1 has several biochemical functions, for example, contributes_to DNA binding, R-SMAD binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXH1 itself. We selected most functions FOXH1 had, and list some proteins which have the same functions with FOXH1. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein SMAD2; RFC3; GTF3C5; FOXH1; NFE2L2A; GTF3C3; ARNTL1B; AHR2; MCM7; MRE11A
Function R-SMAD binding
Related Protein SMAD4; PARP1; MEN1; ZEB2; SMAD3; RANBP3; SMAD2; FOXH1; FOS; PAX6
Function RNA polymerase II transcription cofactor activity
Related Protein MED13B; MED11; MED4; RBM14; CNOT2; MED19A; MED10; MED24; TDG; PPARGC1A
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXD4L1; ZNF444; ATF4; FOXJ1A; OVOL3; ZSCAN1; ERF; MITFB; FOXO1B; FOXP3
Function SMAD binding
Related Protein TGFBRAP1; HIPK2; COL5A2; FOXH1; PURB; BMPR1B; YY1; TCF12; ACVR1B; USP15
Function androgen receptor binding
Related Protein PKN1; FOXP1; RNF4; PIAS1; NRIP1; RNF6; PIAS2; TGFB1I1; PRKCB; DDX5
Function bHLH transcription factor binding
Related Protein TCF3B; EP300; ISL1; USF1; TWIST1; ASCL1; SIRT1; SOX9; USF2; TCF12
Function co-SMAD binding
Related Protein TRIM33; CITED1; SMAD3; SMAD1; SMAD2; SMAD6; TGIF1; FOXH1; GATA4; USP9X
Function enhancer binding
Related Protein SP1; RAI1; TCF12; SOX9; FOXH1; ARNT; MESP1; ELL3; LEF1; SMAD2
Function protein binding
Related Protein DYNC2LI1; DCUN1D5; FKBP5; WWTR1; SPAG5; RAB23; CCDC67; CAMTA2; PLEKHM1; LRRC8C
Function protein domain specific binding
Related Protein HOMER2; ZFP521; KCTD13; CASKIN1; HOMER3; LIN7C; Akap2; TRIM11; TH; GABRR3
Function sequence-specific DNA binding
Related Protein ZNF397; MEOX2; POU2F2; EOMES; HOXC9; NFE2L2A; FOXF1; HOXD13A; LHX2B; OTX1B
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein SMAD2; TAF7; TAF10; NFE2L2A; TRIM28; SMAD3; VDR; SOX1A; SOX19B; MAFGA
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF323; ZNF621; TAF5L; RXRBA; SOX4; FOXN3; ZSCAN16; ZNF234; SLC2A4RG; CNBP
Function transcription regulatory region DNA binding
Related Protein NFE2L2; RFX3; TCF7; OVOL2; NR1H3; Arid4b; HIVEP2; CEBPA; TBP; BCL11B
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein NFE2L2; RELA; HCFC1; SIX6; REL; HOXB5; MIXL1; POU4F1; SPI1; FUBP1
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein LMO2; SOX10; NKX2-5; WWP2; MED12; FOXH1; PITX1; NOTCH1; CLOCK; KLF14

Interacting Protein

FOXH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXH1.
AR; fbe; TCF3; NCK1; PIK3R1; GRB2; SMAD3; SMAD2; TCF12

FOXH1 Related Articles

Chiu, WT; Le, RC; et al. Genome-wide view of TGF beta/Foxh1 regulation of the early mesendoderm program. DEVELOPMENT 141:4537-4547(2014).
Nelson, AC; Cutty, SJ; et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC BIOLOGY 12:-(2014).