FOXH1

  • Official Full Name

    forkhead box H1
  • Overview

    Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.
  • Synonyms

    FOXH1;forkhead box H1;forkhead box protein H1;FAST 1;Fast 2;Fast-1;Fast-2;FAST1;Fast2;Forkhead activin signal transducer 1;Forkhead activin signal transducer 2;FOX H1;FOXH 1;FOXH1_HUMAN;hFAST 1;hFAST-1;hFAST1;Human homolog of Xenopus forkhead activin signal transducer 1;TGF beta/Activin signal transducer FAST1
Cat.# Product name Source (Host) Species Tag Protein Length Price
FOXH1-5991M Recombinant Mouse FOXH1 Protein Mammalian Cells Mouse His
FOXH1-9052Z Recombinant Zebrafish FOXH1 Mammalian Cells Zebrafish His
FOXH1-6156HCL Recombinant Human FOXH1 293 Cell Lysate HEK293 Human Non
FOXH1-2562H Recombinant Human FOXH1 Protein, His-tagged E.coli Human His
FOXH1-3324M Recombinant Mouse FOXH1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FOXH1-3324M-B Recombinant Mouse FOXH1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    FOXH1 involved in several pathways and played different roles in them. We selected most pathways FOXH1 participated on our site, such as Developmental Biology,Heart Development,Regulation of nuclear SMAD2/3 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Activin INHBAA,FSTL3,DRAP1,ACVR1C,FST,FSTB
    Heart Development FOXC1,TBX20,IRX4,HEY1,HEY2,NKX2,NKX2-5,FOXC2,GATA6,SMYD1
    Regulation of nuclear SMAD2/3 signaling NKX2,CITED1,GSC,CBFB,MYOD1,SNIP1,SKI
    TGF-beta Receptor Signaling Pathway ENG,STRAP,STK11IP,HOXD9A,MEF2AA,ZEB2A,ZEB1B,STAMBPL1,NFYBB,ACVRL1
    Signal Transduction FAM123B,KREMEN1,TAAR1,IFT172,WIPF3,PNOC,LEO1,TAS2R7,PYY,ARHGEF1B
    Developmental Biology SEMA3A,TRPC3,KALRN,ST8SIA2,CACNG2B,CEBPA,EPHB3A,FGF8B,EFNB1,COL6A3
    TGF Beta Signaling Pathway ENG,RUNX3,FST,ZFP423,LEFTY1,TGFBR3,NOG,ZNF423
    Signaling by NODAL PCSK6,DRAP1,GDF1,LEFTY1,CFC1,TDGF1,ACVR1C

    Protein Function

    FOXH1 has several biochemical functions, for example, contributes_to DNA binding,R-SMAD binding,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXH1 itself. We selected most functions FOXH1 had, and list some proteins which have the same functions with FOXH1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity RBM14,MED7,MED13,MED13A,NKX2-5,MED24,MED17,MED31,CNOT2,MDT-19
    protein domain specific binding ARFIP2B,YWHAE2,YWHAQ,PPARA,WHRN,HIST1H4C,SORBS2,DDX20,MYH9,PTPN11
    contributes_to transcription factor activity, sequence-specific DNA binding VDRB,TRIM28,SOX1A,MAFGB,VDR,NKX2-5,RXRA,NFE2L2A,TAF10,NKX2
    transcriptional activator activity, RNA polymerase II transcription factor binding NR1H4,SOX10,CLOCK,CREB1,KLF4,JUN,LMO2,NKX2,NOTCH1,PITX1
    SMAD binding DAB2,STUB1,SKOR1B,BMPR1A,BMPR1B,TGFBR1,COL1A2,SOD3,FKBP1A,SMAD2
    bHLH transcription factor binding ASCL1,TCF3A,BHLHE40,TCF4,MAP3K10,EP300,LMO2,TCF21,TWIST1,IKZF4
    co-SMAD binding SMAD3,GATA4,SMAD1,SMAD2,SMAD6,TRIM33,USP9X,CITED1,TGIF1
    transcription regulatory region DNA binding CTCF,HHEX,ARID5B,SP1,FOXM1,XBP1,HINFP,HIVEP3,GRHL1,HDAC1
    contributes_to DNA binding TCF3,MRE11A,NFE2L2A,AHR2,GTF3C3,GTF3C2,MLXIPL,CLOCKA,MCM7,ARNTL1B

    Interacting Protein

    FOXH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXH1.

    AR;fbe;TCF3;NCK1;PIK3R1;GRB2;SMAD3;SMAD2;TCF12

    Resources

    References

    • Chiu, WT; Le, RC; et al. Genome-wide view of TGF beta/Foxh1 regulation of the early mesendoderm program. DEVELOPMENT 141:4537-4547(2014).
    • Nelson, AC; Cutty, SJ; et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC BIOLOGY 12:-(2014).

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