• Official Full Name
  • ferritin, heavy polypeptide 1
  • Background
  • This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FTH1; ferritin, heavy polypeptide 1; FHC; FTH; HFE5; PLIF; FTHL6; PIG15; ferritin heavy chain; apoferritin; ferritin H subunit; placenta immunoregulatory factor; proliferation-inducing protein 15; cell proliferation-inducing gene 15 protein;
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FTH1 Protein (Met1-Ser183)
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FTH1 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FTH1, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FTH1
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FTH1 protein, His & T7-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FTH1 Protein
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fth1 protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FTH1 Protein
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fth1 protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FTH1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FTH1
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep FTH1 protein, His-tagged
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig FTH1 protein, His-tagged
Source (Host):Human PlacentaSpecies:Human
Product nameNative Human Ferritin, Heavy Polypeptide 1
Source (Host):Species:Human
Product nameNative Human FTH1
Source (Host):Species:Human
Product nameNative Human FTH1
Source (Host):Species:Human
Product nameRecombinant Human FTH1 293 Cell Lysate

Involved Pathway

FTH1 involved in several pathways and played different roles in them. We selected most pathways FTH1 participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with FTH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mineral absorption
SLC34A2; ATP1B2; MT1M; MT1A; SLC11A1; VDR; S100G; CLCN2; FTL; MT1H

Protein Function

FTH1 has several biochemical functions, for example, ferric iron binding, ferroxidase activity, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FTH1 itself. We selected most functions FTH1 had, and list some proteins which have the same functions with FTH1. You can find most of the proteins on our site.
Related Protein
Function ferric iron binding
Related Protein FTH1A; MIOX; FTHL17; TF; FXN; FTL; Trf; TH; FTMT; FTH1B
Function ferroxidase activity
Related Protein FTH1; HEPH; CP; HEPHL1; FTMT; FXN
Function iron ion binding
Related Protein EGLN3; SLC11A2; CYP3A5; CYP1C1; CYP2A7; ALOX12; CYP4V7; CYP19A1; Agmo; HBAA1
Function protein binding
Related Protein FAM195B; GLI3; ZNF652; GRIFIN; PI4KA; CDT1; IL6R; BIN1; FOXH1; RIPK4

Interacting Protein

FTH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FTH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FTH1.