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Recombinant Human FTH1 protein, His & T7-tagged

Cat.No. : FTH1-8237H
Product Overview : Recombinant Human FTH1 aa. (Met1~Ser183 (Accession # P02794)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 25.0kDa.
Protein length : Met1~Ser183 (Accession # P02794)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.9.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : FTH1 ferritin heavy chain 1 [ Homo sapiens (human) ]
Official Symbol : FTH1
Synonyms : FTH1; ferritin heavy chain 1; FHC; FTH; HFE5; PLIF; FTHL6; PIG15; ferritin heavy chain; apoferritin; cell proliferation-inducing gene 15 protein; ferritin H subunit; ferritin, heavy polypeptide 1; placenta immunoregulatory factor; proliferation-inducing protein 15
Gene ID : 2495
mRNA Refseq : NM_002032.2
Protein Refseq : NP_002023.2
UniProt ID : P02794

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is FTH1 protein implicated in iron-related disorders? 03/16/2020

Can FTH1 protein be a diagnostic marker for iron-related disorders? 03/20/2019

Yes, FTH1 levels in blood or tissues are sometimes used as diagnostic markers for iron-related disorders, helping to assess iron status in patients.

How is FTH1 protein linked to cancer? 12/16/2018

FTH1's role in iron metabolism is relevant in cancer, where altered iron levels can influence tumor growth. Researchers explore FTH1 as a potential target for cancer therapy.

How does FTH1 relate to inflammation? 07/15/2018

FTH1 is associated with inflammation, as its expression can be influenced by inflammatory signals. This link is of interest in understanding diseases with both iron dysregulation and inflammation.

Can FTH1 be a prognostic marker for certain diseases? 02/21/2018

FTH1 expression levels are being explored as potential prognostic markers in diseases like cancer, providing insights into disease progression and outcomes.

Customer Reviews (3)

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Reviews
07/29/2022

    As a researcher, utilizing FTH1 protein in trials offers numerous advantages that contribute to the successful completion of experiments and the acquisition of valuable data.

    06/22/2021

      manufacturers offer customization options, such as alternative conjugation methods or tailored formulations, allowing researchers to optimize FTH1 protein to their specific experimental needs.

      12/09/2017

        This ensures the consistency and reproducibility of experimental results, promoting confidence in the obtained data.

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