ggt6
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  • Official Full Name
  • gamma-glutamyltransferase 6
  • Background
  • GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular;enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl;moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione;synthesis (Heisterkamp et al., 2008 (PubMed 18357469)).
  • Synonyms
  • GGT6; gamma-glutamyltransferase 6; gamma glutamyltransferase 6 homolog (rat); FLJ90165; Gamma glutamyltranspeptidase 6; GGT 6; gamma-glutamyltranspeptidase 6; gamma-glutamyltransferase 6 homolog
Cat.#:GGT6-4878HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GGT6 Protein, GST-tagged
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Cat.#:GGT6-6333MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GGT6 Protein
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Cat.#:GGT6-2524RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GGT6 Protein
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Cat.#:GGT6-701HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GGT6 cell lysate
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Involved Pathway

GGT6 involved in several pathways and played different roles in them. We selected most pathways GGT6 participated on our site, such as Aflatoxin activation and detoxification, Biological oxidations, Cyanoamino acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aflatoxin activation and detoxification
CYP3A4; ACY3.2; CYP3C4; ACY3.1; ACY3; PRKRA; CYP2A13; DPEP2; CYP3C1; FAM84B
Biological oxidations
CYP1A1; ADH5; CYP2V1; CYP46A1; FAM84B; MTRR; CYP7A1; ACY3.1; POMCB; SULT1C2
Cyanoamino acid metabolism
GGT1A; GGT1; GBA3; GGT5A; GGT6; GGT7; SHMT2; SHMT1; GGT5
Glutathione conjugation
GGTLC1; GSTO2; AKR1A1; GSTK1; GGT6
Glutathione metabolism
GPX3; RRM2B; ANPEPB; GSTA5; GSTA3; GPX4A; GSTM7; GPX4B; GSR; GPX1A
Glutathione synthesis and recycling
GGTLC1; GGT6
Metabolic pathways
UGT2B15; SDSL; PHGDH; ACACA; PIGF; GBA2; INPP5KA; Nat3; PIK3C2G; GNS
Metabolism
CERS4A; CYP27A1; MED21; NEU4; APOEB; APOC2; CPT2; SLC6A12; CBLC-1; FTCD

Protein Function

GGT6 has several biochemical functions, for example, gamma-glutamyltransferase activity, glutathione hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGT6 itself. We selected most functions GGT6 had, and list some proteins which have the same functions with GGT6. You can find most of the proteins on our site.
Function
Related Protein
Function gamma-glutamyltransferase activity
Related Protein GGT5; GGT7; GGT1A; GGT1; GGTLC1; GGT6; GGT5A
Function glutathione hydrolase activity
Related Protein GGT5; GGT6; GGT7; GGT1

Interacting Protein

GGT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGT6.
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