GYPA
-
Official Full Name
glycophorin A (MNS blood group)
-
Overview
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPA gene consists of 7 exons and has 97% sequence homology with GYPB from the 5 UTR to the coding sequence encoding the first 45 amino acids. GYPB accounts for S, s and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are resulted from gene recombinations between GYPA and GYPB. These antigens are expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL, but not on all other cells (mature erythrocytes are characteristically CD235a positive and CD45 and CD71 negative). -
Synonyms
Glycophorin A + B; GYPA; glycophorin A (MNS blood group); glycophorin A (includes MN blood group) , glycophorin A (MN blood group) , MNS; glycophorin-A; CD235a; GPA; MN; glycophorin MiI; glycophorin MiV; glycophorin SAT; glycophorin Erik; glycophorin A, GPA; MN sialoglycop;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canis lupus familiaris (Dog) (Canis familiaris)
- Human
- Macaca fuscata fuscata (Japanese macaque)
- Mouse
- Mus musculus (Mouse)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- FC
- GST
- His (Fc)
- Avi
- Fc
- His|Flag|StrepII
- human|IgG1|Fc|His
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | GYPA-285H | Recombinant Human GYPA Protein, His-tagged | E.coli | His | ||
Human | GYPA-301H | Recombinant Human GYPA protein(Met1-Glu91), His-tagged | HEK293 | C-His | Met1-Glu91 | |
Human | GYPA-29030TH | Recombinant Human GYPA | Wheat Germ | N/A | 150 amino acids | |
Human | GYPA-4507H | Recombinant Human GYPA Protein, His-Flag-StrepII-tagged | Human Cell | His/Flag/StrepII | ||
Human | GYPA-4508H | Recombinant Human GYPA Protein, GST-tagged | Wheat Germ | GST | ||
Human | GYPA-749HCL | Recombinant Human GYPA cell lysate | Human Cell | N/A | ||
Human | GYPA-1408H | Recombinant Human GYPA Protein (20-91 aa), His-tagged | Yeast | His | 20-91 aa | |
Human | GYPA-545H | Recombinant Human GYPA Protein (20-91 aa), GST-tagged | E.coli | GST | 20-91 aa | |
Human | GYPA-3008H | Recombinant Human GYPA protein, His-tagged | E.coli | His | 20-91aa | |
Human | GYPA-215HF | Recombinant Full Length Human GYPA Protein | In Vitro Cell Free System | 150 amino acids | ||
Human | GYPA-056H | Recombinant Human GYPA Protein, His-tagged | E.coli | His | ||
Human | GYPA-3375HF | Recombinant Full Length Human GYPA Protein, GST-tagged | In Vitro Cell Free System | GST | 150 amino acids | |
Human | GYPA-4226H | Recombinant Human GYPA Protein (Met1-Glu91), C-His tagged | Mammalian cells | C-His | Met1-Glu91 | |
Human | GYPA-1345H | Recombinant Human GYPA Protein (Ser20-Gln150), N-His tagged | E.coli | N-His | Ser20-Gln150 | |
Mouse | GYPA-7405M | Recombinant Mouse GYPA Protein | Mammalian Cell | His | ||
Mouse | Gypa-1824M | Recombinant Mouse Gypa protein, His-tagged | E.coli | His | Met1~Val108 | |
Mouse | GYPA-1486M | Recombinant Mouse GYPA protein, Fc-His-tagged | HEK293 | FC/His | Met1-Val108 | |
Mouse | Gypa-267M | Recombinant Mouse Gypa Protein, His and Fc-tagged | HEK293 | His and Fc | 168 | |
Mouse | GYPA-396M | Recombinant Mouse GYPA protein, His/Fc-tagged | HEK293 | human/IgG1/Fc/His | 108 | |
Mouse | GYPA-4019M | Recombinant Mouse GYPA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | GYPA-4019M-B | Recombinant Mouse GYPA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Canis lupus familiaris (Dog) (Canis familiaris) | RFL5212CF | Recombinant Full Length Dog Glycophorin-A(Gypa) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (18-129) | |
Macaca fuscata fuscata (Japanese macaque) | RFL27503MF | Recombinant Full Length Macaca Fuscata Fuscata Glycophorin-A(Gypa) Protein, His-Tagged | E.coli expression system | His | Full Length (1-144) | |
Mus musculus (Mouse) | RFL6985MF | Recombinant Full Length Mouse Glycophorin-A(Gypa) Protein, His-Tagged | E.coli expression system | His | Full Length (1-168) | |
Sus scrofa (Pig) | RFL23215SF | Recombinant Full Length Pig Glycophorin-A(Gypa) Protein, His-Tagged | E.coli expression system | His | Full Length (1-133) |
- Involved Pathway
- Protein Function
- Interacting Protein
- GYPA Related Articles
GYPA involved in several pathways and played different roles in them. We selected most pathways GYPA participated on our site, such as Hematopoietic cell lineage, Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with GYPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Hematopoietic cell lineage | MS4A1;DNTT;FCGR1;CD59;CD3E; CD3D;IL1R2;CD59A;GM2002;Flt3l |
Malaria | HBA1;HBB-B1;HGF;LRP1;CD40;IL6;MYD88;KLRK1;TGFB2 |
GYPA has several biochemical functions, for example, identical protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GYPA itself. We selected most functions GYPA had, and list some proteins which have the same functions with GYPA. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
identical protein binding | TARDBP;HNRNPC;PFKL;DPP9;SRPX2;NQO1;RCAN1;C1S;ADIPOR1 |
virus receptor activity | MRC1;CXADR;ITGB6;HYAL2;CLEC4M;CXCR4;ITGAV;EFNB2;PVRL1 |
GYPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GYPA here. Most of them are supplied by our site. Hope this information will be useful for your research of GYPA.
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All GYPA Products
Required fields are marked with *
My Review for All GYPA Products
Required fields are marked with *