|Official Full Name||chaperonin GroEL|
|Background||This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling;molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported;proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes;functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript;variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause;autosomal recessive spastic paraplegia 13.|
|Synonyms||groEL; chaperonin GroEL; 60 kDa chaperonin; groEL protein; groL; mopA; Protein Cpn60; 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they ar|
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GroEL involved in several pathways and played different roles in them. We selected most pathways GroEL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GroEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
GroEL has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GroEL itself. We selected most functions GroEL had, and list some proteins which have the same functions with GroEL. You can find most of the proteins on our site.
GroEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GroEL here. Most of them are supplied by our site. Hope this information will be useful for your research of GroEL.