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HCN1

  • Official Full Name

    hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

  • Overview

    HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 proteins play an important role for motor learning and synapse formation through integration of cerebellar Purkinje cells. The two proteins also shape autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is particularly high in the cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. Hyperpolarization of activated cation channels of the HCN gene family such as HCN1, contributes to spontaneous rhythmic activity in both heart and brain. HCN channels pass both Na+ and K+ with relative permeability ratio of ~0.15 to 0.25. The primary sequence of HCN pore region is clearly related to that of highly selective K+ channels. In contrast to nonselective CNG or Na+-channels, both K+ and HCN channels contain a GYG motif in the pore.
  • Synonyms

    HCN1; hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCN1-1180HFL Recombinant Human HCN1 protein, His&Flag-tagged HEK293 His&Flag
Mouse HCN1-7519M Recombinant Mouse HCN1 Protein Mammalian Cell His
Mouse HCN1-4082M Recombinant Mouse HCN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HCN1-4082M-B Recombinant Mouse HCN1 Protein Pre-coupled Magnetic Beads HEK293
Rat HCN1-2806R Recombinant Rat HCN1 Protein Mammalian Cell His
Rat HCN1-2461R Recombinant Rat HCN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HCN1-2461R-B Recombinant Rat HCN1 Protein Pre-coupled Magnetic Beads HEK293
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