HIST2H4A Protein, histone cluster 2, H4a


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Official Full Name histone cluster 2, H4a
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008]
Synonyms HIST2H4A; histone cluster 2, H4a; H4; H4/n; H4F2; H4FN; FO108; HIST2H4; histone H4; histone 2, H4a; H4 histone, family 2; histone IV, family 2; H4 histone family, member N;
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • HIS
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HIST2H4A-129H Recombinant Human HIST2H4A Protein, HIS-tagged E.coli HIS
    Human HIST2H4A-303H Recombinant Human HIST2H4A E.coli N/A
    Human HIST2H4A-4814H Recombinant Human HIST2H4A Protein, GST-tagged Wheat Germ GST
    Human HIST2H4A-5514HCL Recombinant Human HIST2H4A 293 Cell Lysate HEK293 N/A

    HIST2H4A involved in several pathways and played different roles in them. We selected most pathways HIST2H4A participated on our site, such as Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST2H4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism CALML3; HIST1H4D; GNG5; CALM2; SLC18A2; CREB5; HDAC3; MAPK3; GNG11; SLC29A1
    Viral carcinogenesis HIST1H4G; GTF2H4; RBL1; HIST1H4F; DLG1; PIK3CD; RANBP1; TRP53; STAT3; GRB2
    Systemic lupus erythematosus HIST1H3H; HIST1H3G; HIST1H4H; HIST1H2AH; HIST1H4N; FCGR4; H2AFY; H3F3C; HIST2H3C1; C8B

    HIST2H4A has several biochemical functions, for example, DNA binding, histone binding, histone demethylase activity (H4-K20 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HIST2H4A itself. We selected most functions HIST2H4A had, and list some proteins which have the same functions with HIST2H4A. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding MNDA; EVX2; TBL1XR1; POLE; TOP1; E2F7; BHLHE41; ZFP367; EVE1; ZFP287
    histone binding NPM2; HIST1H4F; BRDT; SPTY2D1; ASF1A; SMARCA2; RNF168; CHD8; HIST1H4B; PIH1D1
    histone demethylase activity (H4-K20 specific) JHDM1D; HIST1H4C; HIST1H4K; HIST1H4I; HIST1H4F; HIST1H4B; HIST4H4; HIST1H4E; PHF8; HIST1H4A
    poly(A) RNA binding NSUN5; GRB2; GPATCH4; PABPN1; MRPS28; RPL37A; CCT6A; HNRNPDL; ISY1; SF1
    protein binding CCPG1; CLIC2; GGA2; UQCRH; PPP4R1; PTGER4; ANP32A; CDKL3; HOXA10; CSN3
    protein domain specific binding GUSB; VPS11; CBX3; ARFIP1; DVL2; HSPA5; ERCC1; CENPJ; DRD3; WNT5A
    protein heterodimerization activity ADD2; HIST1H2BN; CLNS1A; PPP3CA; H2AFY2; SMC2; PKNOX1; MYF6; BRAF; PPP1CBL

    HIST2H4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST2H4A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST2H4A.

    KDM4A; TP53BP1; SETD8

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