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HSD11B2

  • Official Full Name

    hydroxysteroid (11-beta) dehydrogenase 2

  • Overview

    There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
  • Synonyms

    HSD11B2; hydroxysteroid (11-beta) dehydrogenase 2; corticosteroid 11-beta-dehydrogenase isozyme 2; SDR9C3; short chain dehydrogenase/reductase family 9C; member 3; Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehydrogenase type 2; 11 DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; AME; AME1; DHI2_HUMAN; HSD11K; HSD2; Hydroxysteroid 11 beta dehydrogenase 2; Hydroxysteroid 11 beta dehydrogenase isoenzyme 2; NAD dependent 11 beta hydroxysteroid dehydrogenase; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C, member 3; OTTHUMP00000174801; short chain dehydrogenase/reductase family 9C member 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD11B2-27734TH Recombinant Human HSD11B2 Wheat Germ N/A 100 amino acids
Human HSD11B2-13953H Recombinant Human HSD11B2, GST-tagged Wheat Germ GST
Human HSD11B2-13952H Recombinant Human HSD11B2, GST-tagged E.coli GST 1-405a.a.
Human HSD11B2-13951H Recombinant Human HSD11B2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSD11B2-5378HCL Recombinant Human HSD11B2 293 Cell Lysate HEK293 N/A
Human HSD11B2-1416H Recombinant Human HSD11B2 Protein (1-405 aa), His-tagged Yeast His 1-405 aa
Human HSD11B2-2257H Recombinant Human HSD11B2 Protein, His-tagged E.coli N-His Met105-Arg405
Human HSD11B2-3867HFL Recombinant Full Length Human HSD11B2 protein, Flag-tagged Mamanlian cells Flag
Human HSD11B2-5346H Recombinant Human HSD11B2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSD11B2-2360H Recombinant Human HSD11B2 Protein (Gly106-Arg405), N-His tagged E.coli N-His Gly106-Arg405
Human HSD11B2-6948HF Recombinant Full Length Human HSD11B2 Protein, GST-tagged In Vitro Cell Free System GST 405 amino acids
Human HSD11B2-2361H Recombinant Human HSD11B2 Protein E.coli Tag Free
Mouse HSD11B2-7870M Recombinant Mouse HSD11B2 Protein Mammalian Cell His
Mouse Hsd11b2-1176M Recombinant Mouse Hsd11b2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HSD11B2-4331M-B Recombinant Mouse HSD11B2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSD11B2-4331M Recombinant Mouse HSD11B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD11B2-2921R Recombinant Rat HSD11B2 Protein Mammalian Cell His
Rat Hsd11b2-20R Recombinant Rat Hsd11b2 protein, His-tagged E.coli His Leu58~Pro393
Rat HSD11B2-2576R Recombinant Rat HSD11B2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD11B2-2576R-B Recombinant Rat HSD11B2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HSD11B2-11992Z Recombinant Zebrafish HSD11B2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSD11B2 Related Articles

HSD11B2 involved in several pathways and played different roles in them. We selected most pathways HSD11B2 participated on our site, such as Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD11B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid hormone biosynthesisHSD3B4;UGT2A1;CYP7B1;HSD11B1;CYP3A7;SRD5A2B;HSD3B6;HSD17B8;AKR1C3
Aldosterone-regulated sodium reabsorptionSCNN1B;MAPK3;INS;INS1;FXYD4;PIK3R3;IRS1;SFN;ATP1A4

HSD11B2 has several biochemical functions, for example, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, NAD binding, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD11B2 itself. We selected most functions HSD11B2 had, and list some proteins which have the same functions with HSD11B2. You can find most of the proteins on our site.

Function Related Protein
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activityHSD11B1;HSD11B2
NAD bindingHADHA;HIBADH;ME1;PARP1;AOX4;GAPDHS;HSD11B2;LDHA;HIBADHB
steroid bindingAr;ESRRG;ESRRGA;PDIA2;ESRRGB;ESR2A;PGRMC1;PAQR5;NR3C1

HSD11B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD11B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD11B2.

Seltzer, J; Ashton, CE; et al. Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature. NEUROSURGICAL FOCUS 38:-(2015).
Appleton, AA; Lester, BM; et al. Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. PSYCHONEUROENDOCRINOLOGY 52:32-42(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is HSD11B2 expression regulated in different tissues? 01/26/2021

The expression of HSD11B2 is regulated by various factors in different tissues. In the kidney, where HSD11B2 plays a crucial role in glucocorticoid metabolism, its expression is primarily regulated by aldosterone through the activation of mineralocorticoid receptors. Additionally, other factors, such as angiotensin II and pro-inflammatory cytokines, can also modulate HSD11B2 expression. In tissues outside the kidney, including adipose tissue and the central nervous system, HSD11B2 expression is regulated by a combination of hormonal, metabolic, and inflammatory signals.

What are the implications of altered HSD11B2 activity in metabolic diseases? 08/01/2020

Altered HSD11B2 activity has been implicated in various metabolic diseases. For instance, decreased HSD11B2 activity in adipose tissue has been associated with increased local cortisol levels, contributing to the development of obesity, insulin resistance, and metabolic syndrome. Conversely, increased HSD11B2 activity in other tissues, such as the liver, has been associated with reduced cortisol availability, which may impact glucose metabolism and contribute to the development of hepatic insulin resistance. Understanding the precise mechanisms underlying these associations is crucial for developing targeted therapeutic strategies.

How does HSD11B2 impact the development and progression of cardiovascular diseases? 03/01/2020

HSD11B2 plays a crucial role in cardiovascular health by regulating the balance between cortisol and aldosterone action. Dysregulation of this balance, due to altered HSD11B2 activity, can contribute to the development and progression of cardiovascular diseases. For example, increased cortisol activation of mineralocorticoid receptors in the vasculature can lead to endothelial dysfunction, vascular inflammation, and hypertension. Furthermore, altered HSD11B2 expression in the heart and blood vessels has been associated with cardiac remodeling, fibrosis, and impaired contractility. Understanding the precise mechanisms underlying these effects can provide insights into potential therapeutic interventions.

What are the potential therapeutic strategies targeting HSD11B2? 07/24/2018

Several potential therapeutic strategies targeting HSD11B2 have been explored. These include the development of selective inhibitors that can block the enzyme's activity, leading to increased cortisol availability in specific tissues. Conversely, activators of HSD11B2 could enhance its protective role by promoting cortisol inactivation. Additionally, modulating HSD11B2 expression and activity through lifestyle interventions, such as diet and exercise, may also have therapeutic potential. However, further research is needed to evaluate the efficacy and safety of these strategies in clinical settings.

What is the current understanding of HSD11B2 in the context of stress and mental health? 01/07/2018

The role of HSD11B2 in stress and mental health is an area of active research. Chronic stress has been associated with dysregulation of the hypothalamic-pituitary-adrenal axis and increased cortisol levels, which can influence HSD11B2 activity. Altered HSD11B2 expression and activity in the brain have been implicated in stress-related psychiatric disorders, including depression and anxiety. Furthermore, studies have suggested a potential link between HSD11B2 polymorphisms and susceptibility to stress-related mental health conditions. However, more research is needed to fully elucidate the complex interplay between HSD11B2, cortisol metabolism, and mental health outcomes.

Are there any genetic variations in HSD11B2 associated with disease susceptibility? 12/08/2016

Yes, genetic variations in HSD11B2 have been reported to be associated with disease susceptibility. Single nucleotide polymorphisms (SNPs) in the HSD11B2 gene have been linked to altered enzyme activity and increased risk of developing conditions such as hypertension, cardiovascular disease, and metabolic disorders. These genetic variations can affect HSD11B2 expression, protein stability, or catalytic efficiency, thereby influencing glucocorticoid metabolism and potentially contributing to disease pathogenesis.

What is the physiological role of HSD11B2 in regulating glucocorticoid levels? 08/27/2016

HSD11B2, also known as 11β-hydroxysteroid dehydrogenase type 2, plays a critical role in the regulation of glucocorticoid levels. It acts as a protective enzyme by converting active cortisol into inactive cortisone in mineralocorticoid target tissues, such as the kidney. This enzyme prevents cortisol from binding to the mineralocorticoid receptor, thereby maintaining the selective action of aldosterone on mineralocorticoid receptors. Dysfunction or deficiency of HSD11B2 can lead to excessive cortisol activation of mineralocorticoid receptors, resulting in conditions such as apparent mineralocorticoid excess syndrome.

Customer Reviews (3)

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Reviews
07/30/2022

    Using this reagent, I am able to better explore the functionality and structure of proteins.

    06/14/2022

      Momentum surges as the experiment unfolds, propelled by the prowess of this exceptional reagent.

      03/12/2020

        With this groundbreaking reagent, experiments unfold effortlessly and joyously.

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