|Official Full Name||hydroxysteroid (11-beta) dehydrogenase 2|
|Background||There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.|
|Synonyms||HSD11B2; hydroxysteroid (11-beta) dehydrogenase 2; corticosteroid 11-beta-dehydrogenase isozyme 2; SDR9C3; short chain dehydrogenase/reductase family 9C; member 3; Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehydrogenase type 2; 11 DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; AME; AME1; DHI2_HUMAN; HSD11K; HSD2; Hydroxysteroid 11 beta dehydrogenase 2; Hydroxysteroid 11 beta dehydrogenase isoenzyme 2; NAD dependent 11 beta hydroxysteroid dehydrogenase; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C, member 3; OTTHUMP00000174801; short chain dehydrogenase/reductase family 9C member 3|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
HSD11B2 involved in several pathways and played different roles in them. We selected most pathways HSD11B2 participated on our site, such as Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD11B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Steroid hormone biosynthesis||CYP2D26; CYP2C54; CYP2D10; CYP3A65; SRD5A3; COMTA; UGT1A6; CYP2C39; HSD17B2; CYP3A41B|
|Aldosterone-regulated sodium reabsorption||IRS1; SLC9A3R2; PDPK1; ATP1B1; ATP1A3; HSD11B2; SGK1; MAPK1; INSR; PIK3CB|
HSD11B2 has several biochemical functions, for example, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, NAD binding, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD11B2 itself. We selected most functions HSD11B2 had, and list some proteins which have the same functions with HSD11B2. You can find most of the proteins on our site.
|11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity||HSD11B2; HSD11B1|
|NAD binding||PARP1; DLD; HSD11B2; GPD1; NNT; GPD1B; HIBADHA; GRHPR; IDH3B; IDH3A|
|steroid binding||PAQR7A; CYP21A1; Ar; PAQR8; HSD17B10; ESRRB; PGR; ESR1; CYP21A2; GPR30|
HSD11B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD11B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD11B2.