• Official Full Name
  • HtrA serine peptidase 2
  • Background
  • High temperature requirement protein A2 (HtrA2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress-induced degradation of misfolded proteins. While HtrA2 was orignally identified
  • Synonyms
  • HTRA2; HtrA serine peptidase 2; protease, serine, 25 , PRSS25; serine protease HTRA2, mitochondrial; OMI; PARK13; serine protease 25; protease, serine, 25; serine proteinase OMI; HtrA-like serine protease; Omi stress-regulated endoprotease; high temperatu
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA2, His tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA2, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA2, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA2, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HtrA Serine Peptidase 2, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HTRA2 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HTRA2 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HTRA2 Protein, His-tagged

Involved Pathway

HTRA2 involved in several pathways and played different roles in them. We selected most pathways HTRA2 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTRA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Parkinsons disease

Protein Function

HTRA2 has several biochemical functions, for example, peptidase activity, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTRA2 itself. We selected most functions HTRA2 had, and list some proteins which have the same functions with HTRA2. You can find most of the proteins on our site.
Related Protein
Function peptidase activity
Related Protein MASP2; PARLA; TPP1; ADAMTS4; PM20D1; UCHL3; CAPN2L; CTSSA; TMPRSS11D; C1rb
Function protein binding
Related Protein CHMP6; NUP85; SIGLEC5; CDC45; COPS7B; FAM151B; BPIFA2; APOA4; PEG10; USP47
Function serine-type endopeptidase activity
Related Protein PCSK2; CELA2A; HP; CTRL; GZMH; PRSS44; CMA1; PRSS8; PRSS59.1; HTRA4
Function serine-type peptidase activity
Related Protein SEC11C; GZMM; HTRA1B; KLK12; NAALAD2; PRSS30; TPSG1; PRSS52; HTRA1; ST14A
Function unfolded protein binding
Related Protein HSPD1; CCDC102A; LMAN1; NDUFAF1; DNAJB5; HSP104; HSPA5; TOMM20; CCT6A; AHSP

Interacting Protein

HTRA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTRA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTRA2.

HTRA2 Related Articles

Suwannaboon, R; Phiwsaiya, K; et al. The identification and expression of the full-length HtrA2 gene from Penaeus monodon (black tiger shrimp). PROTEIN EXPRESSION AND PURIFICATION 92:183-189(2013).
Oliveira, RDR; Fontana, V; et al. Differential Gene Expression Profiles May Differentiate Responder and Nonresponder Patients with Rheumatoid Arthritis for Methotrexate (MTX) Monotherapy and MTX plus Tumor Necrosis Factor Inhibitor Combined Therapy. JOURNAL OF RHEUMATOLOGY 39:1524-1532(2012).