Recombinant Human HTRA2, His-tagged

• Cat.No.: HTRA2-14010H
• Product Overview: Recombinant Human HTRA2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 133-458a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: HTRA2 HtrA serine peptidase 2 [ Homo sapiens ]
• Official Symbol: HTRA2
• Synonyms: HTRA2; HtrA serine peptidase 2; protease, serine, 25 , PRSS25; serine protease HTRA2, mitochondrial; OMI; PARK13; serine protease 25; protease, serine, 25; serine proteinase OMI; HtrA-like serine protease; Omi stress-regulated endoprotease; high temperature requirement protein A2; PRSS25
• Gene ID: 27429
• mRNA Refseq: NM_013247
• Protein Refseq: NP_037379
• MIM: 606441
• UniProt ID: O43464
• Chromosome Location: 2p13.1
• Pathway: Parkinsons disease, organism-specific biosystem
• Function: peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity; serine-type peptidase activity; unfolded protein binding