Recombinant Human HTRA2, His-tagged

• Cat.No.: HTRA2-26919TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 134-458 of Human HtrA2 / Omi, with a C terminal His-Tag.32 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 134-458 a.a.
• Description: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
• Conjugation: HIS
• Tissue specificity: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAVPSPPPAS PPSQYNFIAD VVEKTAPAVV YIEILDRHPF LGREVPISNG SGFVVAADGL IVTNAHVVAD RRRVRVRLLS GDTYEAVVTA VDPVADIATL RIQTKEPLPT LPLGRSADVR QGEFVVAMGS PFALQNTITS GIVSSAQRPA RDLGLPQTNV EYIQTDAAID FGNAGGPLVN LDGEVIGVNT MKVTAGISFA IPSDRLREFL HRGEKKNSSS GISGSQRRYI GVMMLTLSPS ILAELQLREP SFPDVQHGVL IHKVILGSPA HRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR TQSQLAVQIR RGRETLTLYV TPEVTE- GSHHHHHH
• Sequence Similarities: Belongs to the peptidase S1B family.Contains 1 PDZ (DHR) domain.
• Full Length: Full L.

Gene Information

• Gene Name: HTRA2 HtrA serine peptidase 2 [ Homo sapiens ]
• Official Symbol: HTRA2
• Synonyms: HTRA2; HtrA serine peptidase 2; protease, serine, 25 , PRSS25; serine protease HTRA2, mitochondrial; OMI; PARK13
• Gene ID: 27429
• mRNA Refseq: NM_013247
• Protein Refseq: NP_037379
• MIM: 606441
• Uniprot ID: O43464
• Chromosome Location: 2p13.1
• Pathway: Parkinsons disease, organism-specific biosystem
• Function: peptidase activity; protein binding; serine-type endopeptidase activity; unfolded protein binding