This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IRX5; iroquois homeobox 5; iroquois-class homeodomain protein IRX-5; IRX 2a; Homeodomain protein IRX-2A; Homeodomain Protein IRXB2; Iroquois Homeobox Protein 5; IRX2A; IRX5_HUMAN; IRXB2; OTTHUMP00000164259; OTTHUMP00000164260; IRX-2a
IRX5 involved in several pathways and played different roles in them. We selected most pathways IRX5 participated on our site, such as miR-1 in cardiac development, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Related Protein
miR-1 in cardiac development
IRX5 has several biochemical functions, for example, DNA binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRX5 itself. We selected most functions IRX5 had, and list some proteins which have the same functions with IRX5. You can find most of the proteins on our site.
Function DNA binding
Related Protein POLR2EB; FOXO4; AGFG1; SMAD6A; STRA13; ZNF12; HIST2H2AC; RAD52; TXLNB; MYCL1
Function sequence-specific DNA binding
Related Protein KLF5; RARAA; BCL2; FOXO3B; FOXO1A; ALX3; FOXO1B; RORB; MAFF; FOXJ2
IRX5 Related Articles
Jung, EJ; Park, HB; et al. Genome-wide association analysis identifies quantitative trait loci for growth in a Landrace purebred population. ANIMAL GENETICS 45:442-444(2014).
Sato, T; Kobayashi, T; et al. Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 306:H1054-H1065(2014).