itga1
Share
  • Official Full Name
  • integrin, alpha 1
  • Background
  • This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to;form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion;and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor;type I domain which is thought to be involved in collagen binding.
  • Synonyms
  • ITGA1; integrin, alpha 1; integrin alpha-1; CD49a; VLA1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A
Cat.#:ITGA1-5002HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA1 Protein, GST-tagged
+Inquiry
Cat.#:ITGA1-29494THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITGA1
+Inquiry
Cat.#:ITGA1-6797HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGA1 protein, His-tagged
+Inquiry
Cat.#:Itga1-6798MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itga1 protein, His-tagged
+Inquiry
Cat.#:ITGA1-3111RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITGA1 Protein
+Inquiry
Cat.#:Itga1-6799RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itga1 protein, His & T7-tagged
+Inquiry
Cat.#:ITGA1-6626CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGA1
+Inquiry
Cat.#:ITGA1-6796CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken ITGA1 protein, His & T7-tagged
+Inquiry
Cat.#:ITGA1-5137HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGA1 293 Cell Lysate
+Inquiry

Involved Pathway

ITGA1 involved in several pathways and played different roles in them. We selected most pathways ITGA1 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
LAMA2; ITGA10; FGF4; GNG3; MLST8; IL7; LAMC1; TCL1A; NFKB1; F2R
Focal adhesion
RAC1B; RAC1; PIK3R3B; PPP1CAB; COL24A1; LAMC1; RAC3B; VASP; RAPGEF1B; PIK3CA
ECM-receptor interaction
GP5; Npnt; COL6A3; ITGB4; VWF; CHAD; THBS3; COL27A1A; THBS4; ITGA8
Hematopoietic cell lineage
Il4ra; KITLG; IL5; IL3; IL11RA2; CD1E; IL4; IL9R; HLA-DRB4; IL1B
Regulation of actin cytoskeleton
GIT1; PXNA; PPP1CB; CYFIP1; FGF13A; PIK3CD; ITGAV; ACTB2; BCAR1; VCLA
Hypertrophic cardiomyopathy (HCM)
ITGB4; TPM1; SGCB; MYL3; DAG1; SGCG; TGFB2; ITGA2; TTN; MYL2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
DSG2; PKP2; SGCB; DAG1; ACTN4; ITGA9; LEF1; ACTG1; LMNA; ITGB8
Dilated cardiomyopathy
TGFB1; ACTC1; CACNG8; MYH7; MYL3; TPM2; SLC8A1; ATP2A2; ITGB8; CACNB2

Protein Function

ITGA1 has several biochemical functions, for example, collagen binding, collagen binding involved in cell-matrix adhesion, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA1 itself. We selected most functions ITGA1 had, and list some proteins which have the same functions with ITGA1. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein SPARC; SMAD4; CTSL1; CD44; SERPINH1B; USH2A; ANTXR1; VWF; ITGA9; PCOLCE
Function collagen binding involved in cell-matrix adhesion
Related Protein ITGA1; ITGA2; ITGA10; ITGB1; Itga10&Itgb1
Function metal ion binding
Related Protein PAPL; NUDT1; DMRTA2; CYP1D1; ZFP654; ZNF652; TNKS2; NR2F1A; ADIPOR2; MLL1
Function protein binding
Related Protein UGP2; MFF; LRRC26; FANCM; PLEKHG6; ABCF1; TEX264; ABTB1; TRPC4AP; RBL2
Function protein phosphatase binding
Related Protein ROS1; GNB2L1; ANAPC5; TRAF3; TRP53; RPA2; SKAP1; PPP1R3C; PIK3R2; HSF4
Function receptor binding
Related Protein FYNA; LTB; SMARCD1; TNFSF8; WNT4B; FGF8A; C3; APOL2; FYNB; RARA

Interacting Protein

ITGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA1.
PTPN2; FABP3; Rab21; Sharpin; Fabp3; proS; terA; Iqgap3; Hax1; Itgb1; LIMK1; Magoh; FAM178A; Csnk1d; Gnpnat1