| Official Full Name | integrin, alpha 1 |
| Background | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to;form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion;and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor;type I domain which is thought to be involved in collagen binding. |
| Synonyms | ITGA1; integrin, alpha 1; integrin alpha-1; CD49a; VLA1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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ITGA1 involved in several pathways and played different roles in them. We selected most pathways ITGA1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | BAD; GNG7; RPS6KB2; YWHAG; PIK3R2; PKN1; LAMC2; IL7R; PPP2R5D; FGF12 |
| Focal adhesion | THBS4B; LAMA2; CAPN2A; VAV1; RAC3; VTNB; COL4A1; PDGFRB; MAPK6; PTENB |
| ECM-receptor interaction | THBS2; COL6A2; ITGB3B; ITGB1B.2; CD36; COL11A2; LAMA3; SDC4; IBSP; ITGB7 |
| Hematopoietic cell lineage | IL4; IL3RA; GP9; CSF1; CD4; FLT3LG; EPO; IL2RA; CD8A; CD1E, B2M |
| Regulation of actin cytoskeleton | FGF6; INSB; ITGA5; ACTN1; ITGA3; ARPC5A; ITGA10; CHRM5B; PIP5K1B; ABI2B |
| Hypertrophic cardiomyopathy (HCM) | CACNB4; SGCB; TGFB3; ITGAV; TPM3; SGCA; TGFB1; ITGA5; TNF; PRKAB1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | TCF7L2; CTNNA2; DAG1; ITGA3; ACTB; ITGA9; CACNG3; CACNB3; Itga10&Itgb1; ITGA2 |
| Dilated cardiomyopathy | TTN; ITGB3; ITGB1; PLN; CACNG6; CACNG4; SGCG; ITGB6; RYR2; LAMA2 |
ITGA1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA1 itself. We selected most functions ITGA1 had, and list some proteins which have the same functions with ITGA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | PDGFA; MTAP1A; COMP; CCBE1; Pdgfa&Pdgfb; VWF; ITGA9; TLL1; DDR2; SERPINH2 |
| collagen binding involved in cell-matrix adhesion | Itga10&Itgb1; ITGA2; ITGB1; ITGA1; ITGA10 |
| metal ion binding | NUBP2; PRDM1A; FGD; OSR2; PDE8B; HMGCL; OAS3; RNF11B; ZBTB25; RUFY2 |
| protein binding | HNRNPR; GOLM1; UNC13D; WDR34; RNF4; PIANP; KRTAP4-12; PPP1R12A; CCDC22; NME3 |
| protein phosphatase binding | MVP; CDH2; FGF19; FLT4; HSF4; MET; Itga10&Itgb1; HSP90B1; ITGA1; STAT6 |
| receptor binding | IDH1; NRG2A; P2RX4; CADM3; APOF; Itga10&Itgb1; FGF24; ASIP; NXPH3; DRD1A |
ITGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA1.
PTPN2; FABP3; Rab21; Sharpin; Fabp3; proS; terA; Iqgap3; Hax1; Itgb1; LIMK1; Magoh; FAM178A; Csnk1d; Gnpnat1
