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Official Full Name integrin, alpha V
Background Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.
Synonyms ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor s
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Avi
    • T7
    • His-Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGAV & ITGB1-746H Recombinant Human ITGAV & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAV & ITGB3-311H Recombinant Human ITGAV & ITGB3 protein, His-Avi-tagged HEK293 His-Avi
    Human ITGAV & ITGB3-738H Recombinant Human ITGAV & ITGB3 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAV & ITGB5-336H Recombinant Human ITGAV & ITGB5 protein, His-Avi-tagged HEK293 His-Avi
    Human ITGAV & ITGB5-758H Recombinant Human ITGAV & ITGB5 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAV & ITGB6-760H Recombinant Human ITGAV & ITGB6 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAV-1427H Recombinant Human ITGAV Protein (891-1048 aa), His-tagged Yeast His
    Human ITGA5-101H Recombinant Human ITGAV/ITGB3 Heterodimer Protein, His-tagged HEK293 His
    Human ITGAV&ITGB1-740H Recombinant Human ITGAV&ITGB1 CHO N/A
    Human ITGAV&ITGB1-745H Recombinant Human ITGAV/ITGB1 Heterodimer Protein, His-tagged HEK293 His
    Human ITGAV&ITGB3-739H Recombinant Human ITGAV/ITGB3 protein, His-tagged HEK293 His
    Human ITGAV&ITGB6-741H Recombinant Human ITGAV&ITGB6 CHO N/A
    Human ITGAV&ITGB6-759H Recombinant Human ITGAV/ITGB6 Heterodimer Protein, His-tagged HEK293 His
    Human ITGAV-26862TH Recombinant Human ITGAV protein Wheat Germ N/A
    Human ITGAV-4988H Recombinant Human ITGAV Protein, GST-tagged Wheat Germ GST
    Human ITGAV-6763H Recombinant Human ITGAV protein, His-tagged E.coli His
    Human ITGAV-877HCL Recombinant Human ITGAV cell lysate N/A
    Human ITGAVB3-103H Recombinant Human ITGAVB3 CHO N/A
    Mouse Itgav-6764M Recombinant Mouse Itgav protein, His & T7-tagged E.coli His/T7
    Mouse ITGAV-8360M Recombinant Mouse ITGAV Protein Mammalian Cell His
    Rat Itgav&Itgb6-23R Recombinant Rat Itgav&Itgb6 Protein CHO N/A
    Rhesus Macaque ITGAV-2315R Recombinant Rhesus monkey ITGAV Protein, His-tagged Mammalian Cell His
    Chicken ITGAV-6989C Recombinant Chicken ITGAV Mammalian Cell His
    Zebrafish ITGAV-3406Z Recombinant Zebrafish ITGAV Mammalian Cell His

    ITGAV involved in several pathways and played different roles in them. We selected most pathways ITGAV participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAV were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway TSC2; ITGA6; TSC1; PKN2; AKT2; TRP53; YWHAZ; FOXO3; Il2; RPS6
    ECM-receptor interaction ITGA1; LAMB1; SDC4; FN1A; ITGA6; COL24A1; LAMC2; LAMB2; SDC1; LAMB1A
    Cell adhesion molecules (CAMs) CLDN5; SPN; PVRL3; CLDNJ; ITGB1; SDC1; NLGN2B; LRRC4B; PTPRM; CDH15
    Regulation of actin cytoskeleton ARPC5LA; FGF6; ITGB3; ABI2B; DIAP3; PDGFAB; INS2; PIK3R1; GNA13A; PDGFC
    Thyroid hormone signaling pathway SLC2A1; PRKCG; NOTCH3; HDAC1; ATP1B1; PLCB1; ATP1B2; RXRG; MED30; ITGB3
    Pathways in cancer CASP8; PLEKHG5; NFKBIA; STAT1; CCND1; HGF; HSP90B1; MAPK9; FGFR1; WNT3A
    Proteoglycans in cancer MAP2K2; FZD9; NANOG; SDC4; PRKCA; FLNA; WNT11; RAC1; WNT5A; IL12B
    Small cell lung cancer RARB; TP53; LAMB3; MAX; TRAF2; LAMB4; IKBKB; CCNE1; RXRA; LAMC1
    Hypertrophic cardiomyopathy (HCM) SGCG; PRKAG3; CACNA2D2; Itga10&Itgb1; CACNB4; ITGA2B; ITGA10; TTN; CACNA2D1; MYH7
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGB3; LAMA2; CACNG2; CACNG8; SGCA; ITGA6; JUP; SGCD; ACTG1; LMNA
    Dilated cardiomyopathy MYL3; Itga10&Itgb1; MYH7; ITGB1; GNAS; CACNB3; ITGA9; ITGA4; SLC8A1; LAMA2

    ITGAV has several biochemical functions, for example, extracellular matrix binding, extracellular matrix protein binding, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAV itself. We selected most functions ITGAV had, and list some proteins which have the same functions with ITGAV. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix binding SID4; SPOCK2; TGFBI; VEGFA; ITGA2B; FBLN2; DCN; ITGB3; SPARC; BGN
    extracellular matrix protein binding MEPE; ITGB8; ITGAV
    fibronectin binding LPA; SFRP2; MMP13; LRRC15; MFAP2; CTSL1; ITGA3; FSTL3; ITGAV; LACRT
    contributes_to insulin-like growth factor I binding ITGAV
    metal ion binding PPM1F; RNF34B; XPA; ME2; PMELA; FBXO30A; CLCA5; RORCB; ASH2L; COL5A2
    contributes_to opsonin binding ITGAV
    protease binding Casp3; SELL; VWF; TNF; INS; SERPINB9; TIMP2B; Serpina1b; RFFL; SERPINA1
    protein binding TSSK1; ZFYVE20; FOXK2; CEP70; PRKCA; NETO2; NLRP2; WDR92; PRSS2; ELMO1
    contributes_to protein kinase C binding ITGAV
    transforming growth factor beta binding HYAL2; ACVR1; ENG; ACVRL1; TGFBR3; TGFB3; ITGAV; TGFBR1; TGFBR2; LTBP4
    virus receptor activity SIVA1; CD46; IDE; CXCR4; CXADR; ITGB3; ACE2; ITGB5; ITGA5; SLAMF1
    voltage-gated calcium channel activity CACNB3A; NCS1; ATP6V0CB; CACNG2; CACNA2D4; CACNG4; TPCN2; CACNB2; CACNA1C; CACNA2D1

    ITGAV has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAV here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAV.


    Shakiba, E; Tavilani, H; et al. The ITGAV-rs3911238 Polymorphism Is Associated with Disease Activity in Rheumatoid Arthritis. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 13:356-363(2014).
    Inamine, T; Nakamura, M; et al. A polymorphism in the integrin alpha V subunit gene affects the progression of primary biliary cirrhosis in Japanese patients. JOURNAL OF GASTROENTEROLOGY 46:676-686(2011).

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