Active Recombinant Human ITGAV Protein, C-6×His-tagged
Cat.No. : | ITGAV-26H |
Product Overview : | Recombinant Human Integrin alpha V (Phe31-Val992, Acidic Tail) with a 6×His tag at C-terminus and Human Integrin beta 1 (Gln21-Asp728, Basic Tail) was expressed in Chinese Hamster Ovary cell line. |
- Specification
- Gene Information
- Related Products
Description : | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. |
Source : | CHO |
Species : | Human |
Tag : | C-6×His |
Form : | Noncovalently-linked heterodimer |
Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Human Fibronectin is immobilized at 2 μg/mL, 100 μL/well, Recombinant Human Integrin alpha V beta 1 binds with an ED50 of 0.08-0.48 μg/mL. |
Molecular Mass : | Predicted Molecular Mass: 115 kDa ( alpha V subunit) & 86 kDa ( beta 1 subunit) SDS-PAGE: 120-170 kDa, reducing conditions |
Protein Length : | Integrin alpha V: Phe31-Val992 Integrin beta 1: Gln21-Asp728 |
N-terminal Sequence Analysis : | Phe31 ( alpha V subunit) & Gln21 ( beta 1 subunit, inferred from enzymatic pyroglutamate treatment revealing Thr22) |
Endotoxin : | <1.0 EU/μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
Reconstitution : | Reconstitute at 500 μg/mL in water. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | ITGAV integrin subunit alpha V [ Homo sapiens (human) ] |
Official Symbol : | ITGAV |
Synonyms : | ITGAV; integrin subunit alpha V; integrin alpha-V; antigen identified by monoclonal antibody L230; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); vitronectin receptor subunit alpha |
Gene ID : | 3685 |
mRNA Refseq : | NM_002210 |
Protein Refseq : | NP_002201 |
MIM : | 193210 |
UniProt ID : | P06756 |
Products Types
◆ Recombinant Protein | ||
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ITGAV-2136R | Recombinant Rhesus Macaque ITGAV Protein, His (Fc)-Avi-tagged | +Inquiry |
ITGAV-2343H | Recombinant Human ITGAV Protein, His-tagged | +Inquiry |
Itgav-1700R | Recombinant Rat Itgav Protein, His-tagged | +Inquiry |
Itgav&Itgb6-23R | Recombinant Rat Itgav&Itgb6 Protein | +Inquiry |
◆ Lysates | ||
ITGAV-877HCL | Recombinant Human ITGAV cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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