ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PIK3R2; CSF1; CALM1; INS2; RASA1; PLCE1; GNG11; MLLT4; FGF8; FGF5
Rap signaling pathway
MAPK12; ITGB2; FGFR1; PFN3; MAPK3; SKAP1; RASGRP3; FGFR3; PDGFA; KLK1B4
cGMP-PKG signaling pathway
SLC25A5; SLC25A6; PDE3B; NPR1; MAPK1; SLC25A31; RGS2; GNAQ; INS; PPP3R1
HIF- signaling pathway
MAPK3; RPS6KB2; RPS6KB1; MTOR; TFRC; IGF1R; LDHA; BCL2; CAMK2A; CUL2
FoxO signaling pathway
RAF1A; GABARAP; PLK2; INSRB; AKT3A; FOXO3B; GRB2A; INSR; GADD45G; SETD7
Phospholipase D signaling pathway
KRAS; AVPR1B; LPAR6; PTPN11; AGPAT4; INS1; PLCB2; TSC2; MS4A2; GNA12
Oocyte meiosis
ITPR3; YWHAG; CDC25C; CAMK2B1; PRKACBA; MAP2K1; PGR; PPP2R5CB; FBXO43; RPS6KA2
Regulation of autophagy
ATG4C; GABARAPL2; PRKAA1; GABARAPL1; ATG4D; INS1; GABARAPA; ATG3; ULK2; IFNA5
mTOR signaling pathway
CAB39L1; DDIT4; PIK3CG; TSC1; IRS1; PRKCBB; IGF1; MLST8; PIK3CA; RPS6KA2
PIK-Akt signaling pathway
IFNA1; PRLR; YWHAE; PHLPP2; LAMA3; ITGA8; CREB3L1; FGFR2; LAMB3; SPP1
AMPK signaling pathway
PPARG; CCNA2; IRS1; EIF4EBP1; LIPE; STK11; PPP2R2D; PRKAA1; PPP2R5D; PIK3CG
Regulation of actin cytoskeleton
ITGB4; PAK3; PPP1R12B; ITGA3; IQGAP3; ROCK2; FGF6B; ITGB6; ARHGEF7B; CYFIP2
Insulin signaling pathway
SOCS1; PTPN1; SOCS4; PPARGC1A; INPP5K; MAPK8A; PKLR; ACACA; PRKAG1; MAP2K2
Insulin secretion
KCNMB2; CAMK2A; PRKACG; KCNN3; KCNN4; CCKAR; ATP1B2; KCNMB4; ATP1A1; RAB3A
Ovarian steroidogenesis
PLA2G4F; BMP6; FSHR; INS; CYP2J6; INS1; LHB; PRKACG; PTGS2; SCARB1
Progesterone-mediated oocyte maturation
MAPK14A; PIK3R3A; GNAI2A; AKT2; CPEB1A; SPDYB; PRKACAB; ANAPC5; MAP2K1; AKT2L
Prolactin signaling pathway
SOCS6; ESR1; AKT1; TH; PIK3R5; MAPK13; SOCS2; GSK3B; MAPK8; STAT5B
Regulation of lipolysis in adipocytes
PIK3R2; GNAI2; GNAI3; NPY; PIK3R3; PRKG1; PTGER3; PNPLA2; PRKACG; FABP4
Type II diabetes mellitus
SOCS1; INS1; PIK3CB; SLC2A2; PKM; PIK3R3; INS; IRS1; SOCS2; SOCS4
Insulin resistance
G6PCA.1; RPS6KA3; PTPN11B; MAPK8B; PRKCQ; PPP1CA; PPARAB; MAPK8; MTOR; OGT.1
Non-alcoholic fatty liver disease (NAFLD)
MAPK10; NDUFB6; NDUFB3; GSK3B; PRKAG3; INS; NR1H3; PKLR; BID; FASLG
Type I diabetes mellitus
H2-Q10; HLA-F; HLA-G; ICA1; HLA-DRB3; HLA-DPA1; HLA-DQB1; IL1A; IL1B; INS1
Maturity onset diabetes of the young
BHLHA15; PDX1; INS1; HNF1B; PAX4; PAX6; INS2; HES1; MNX1; SLC2A2
Aldosterone-regulated sodium reabsorption
NR3C2; ATP1A1; ATP1B3; PIK3CD; ATP1A4; FXYD2; INS; ATP1B1; NEDD4L; SCNN1G
Prostate cancer
HRAS; PIK3R1; IKBKG; BRAF; PDGFRA; TGFA; TRP53; PIK3R2; BAD; AKT2

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein ADIPOQ; GCGA; SCT; PTH1A; PRL8A8; EPO; ADM; EDN1; SMTLA; GH2
Function identical protein binding
Related Protein CLDN11; MSTN; TTR; CLDNG; CUBN; HCFC1; MPST; SETX; RCAN1; TNN
Function insulin receptor binding
Related Protein FRS2A; INS2; DOK5; SNX2; IRS1; FRS2; DOK6; SNX1; SHC1; IRS2
Function insulin-like growth factor receptor binding
Related Protein GNAS; INSR; Ren1; IGF2B; IGF2A; INS2; INS; ARRB1; REN; IGF3
Function protease binding
Related Protein F3; KIT; CD28; INSL3; ADRM1; NFRKB; SERPINB9; SERPINB6; Serpina1b; NDUFS7
Function protein complex binding
Related Protein SLC25A3; PPFIA2; COG2; VPS28; Cel; KIF11; CPS1; GNB2; PFKP; CYFIP1