ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
FIGF; FGFR4; PIK3R5; PAK1; KRAS; PDGFRA; GNG3; GRIN2A; CALM4; ANGPT2
Rap signaling pathway
VAV2; FYB; MAGI1; Fgf15; MAPK11; RAC1; PDGFC; PIK3CB; IGF1R; IGF1
cGMP-PKG signaling pathway
GNAI3; PRKG2; GNA12; MYLK; CALM2; SLC8A2; PIK3CA; MEF2C; PPP1R12A; CALML3
HIF- signaling pathway
ENO2; RBX1; IFNGR1; HK2; GM5506; PRKCA; HK1; PIK3CB; RELA; AKT1
FoxO signaling pathway
FOXO1A; SKP2; PIK3CA; GRM1; PIK3R3B; IRS2; GADD45AA; FOXO3; GADD45BB; MAP2K2A
Phospholipase D signaling pathway
MAPK3; PLCB4; AKT1; SHC4; TSC2; PIK3R2; PLCB2; CYTH4; PLD1; KRAS
Oocyte meiosis
FBXO43; BTRC; RPS6KA3B; PPP2CA; PPP2R1B; YWHAG; PPP2R1A; CDC20; RPS6KA3; CDC16
Regulation of autophagy
ATG4D; INS1; IFNA10; IFNA14; ATG4C; ATG13; BECN1; IFNA12; ULK3; IFNA5
mTOR signaling pathway
PDPK1B; STRADA; PTENB; RPS6KA6; PIK3R3; RPS6KA1; PIK3R1; PRKCA; RPS6KA2; PTENA
PIK-Akt signaling pathway
TCL1; COL4A1; IFNB1; GNB2; GNG11; PIK3R2; STK11; FN1; RPS6KB2; PPP2R2C
AMPK signaling pathway
MAP3K7; TBC1D1; PIK3CD; ADIPOR1; SREBF1; EEF2; PIK3CA; RAB8A; GYS1; AKT3
Regulation of actin cytoskeleton
MYL2B; ITGA11A; ARHGEF7; ITGA2B; ARPC5L; PIP5K1AA; ITGB1A; PIK3R5; FGF9; TMSB4X
Insulin signaling pathway
BAD; PHKG1B; CALM1; HRASB; EIF4E2; CALML5; BRAF; SHC3; ACACB; PRKACAA
Insulin secretion
RYR2; ATP1B4; PRKCG; PCLO; SLC2A1; CCKAR; ATP1A2; KCNMB2; ATP1B2; CREB3L2
Ovarian steroidogenesis
HSD3B1; INS2; HSD3B5; ALOX5; CYP2J5; FSHR; LDLR; INSR; LHB; PRKACA
Progesterone-mediated oocyte maturation
PIK3R5; CCNA1; PLK1; CPEB1; MAPK9; CCNA2; RAF1B; GNAI1; CDC23; ANAPC5
Prolactin signaling pathway
SOCS7; INS; ESR2; IRF1; PIK3R3; RELA; SLC2A2; NRAS; SHC4; FOS
Regulation of lipolysis in adipocytes
GNAI2; FABP4; AQP7; PRKG2; GNAI1; IRS4; GNAS; AKT1; PIK3R3; GNAI3
Type II diabetes mellitus
MAPK8; SOCS4; MAFA; INSR; MTOR; HKDC1; INS; MAPK10; SOCS3; INS1
Insulin resistance
PPP1R3CA; G6PCA.1; PPP1R3C; OGT; SLC27A2; PIK3R3; STAT3; MTOR; SLC27A3; NFKBIAA
Non-alcoholic fatty liver disease (NAFLD)
PIK3CG; NDUFA3; COX5A; IRS1; CASP7; NDUFA1; EIF2AK3; PRKAB1; FAS; RELA
Type I diabetes mellitus
IL1A; INS1; HLA-B; H2-AB1; INS; LTA; HLA-DMA; CD28; HLA-DRA; CPE
Maturity onset diabetes of the young
HNF1A; NKX6-1; HNF1B; INS1; HHEX; INS2; FOXA3; IAPP; PAX4; PDX1
Aldosterone-regulated sodium reabsorption
INSR; MAPK1; ATP1B3; KCNJ1; PDPK1; SCNN1G; PRKCB; HSD11B2; ATP1A4; INS
Prostate cancer
SOS1; PTEN; FGFR2; SMARCD1; Pdgfa&Pdgfb; SPINK1; PIK3CB; ACTL6B; SMARCC2; FOXA1

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein CCL25; GPHB5; CHGB; PRL3B1; ADCYAP1B; INSL5B; SST1.1; RETN; APLN; CCK
Function identical protein binding
Related Protein EPOR; SYNE1; BCHE; ALK; GOT1L1; MAPK1IP1; PIK3AP1; THG1L; COIL; LDHB
Function insulin receptor binding
Related Protein DOK7; FRS3; IRS1; FRS2B; SLC2A2; FRS2; IRS4; DOK4; IGF2; INS1
Function insulin-like growth factor receptor binding
Related Protein IGF2A; INS2; IGF2B; YWHAG; YWHAH; IGF2; PIK3R1; SOCS2; IRS1; IGF3
Function protease binding
Related Protein VWF; FLOT2; FURIN; INSL3; PYCARD; CSTA; ANXA2; BDKRB2; PINK1; Casp3
Function protein complex binding
Related Protein NCKAP1L; ABI2; TAPBPL; LEPRE1; LCA5; C8B; KIF11; BAX; Cel; RPTOR