ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
MAPK8; BAD; GNG3; PLA2G4A; GRIN2A; PAK1; FGF6; ANGPT1; GNG7; FGF10
Rap signaling pathway
FGF6; PRKCZ; MAGI2; KRIT1; FGF9; PDGFRB; KLK1B4; RALB; RAPGEF6; SIPA1L2
cGMP-PKG signaling pathway
KCNMB3; ATP2A2; CALM1; PRKG1; MEF2C; CALM2; PRKCE; PPP1R12A; PPP3R2; ATP2B4
HIF- signaling pathway
PIK3CB; RPS6KB1; CUL2; MKNK2; IFNGR2; NOX1; IGF1R; MAP2K2; VEGFA; INS
FoxO signaling pathway
PLK2; G6PCA.2; IGF1RA; PRKAB2; INS; MAPK12A; NLK2; SGK2B; TGFB1; TGFBR2
Phospholipase D signaling pathway
MAP2K1; GAB1; RALGDS; PDGFRA; PIK3CA; Kitl; PLD2; RRAS2; AGTR1B; TSC2
Oocyte meiosis
PPP3CB; PRKACBA; PPP2R5C; FBXW11A; PPP2R5D; PPP1CB; CDC20; PPP2CA; ANAPC13; MAP2K1
Regulation of autophagy
IFNA16; ATG4B; INS; PIK3C3; ATG16L1; ATG12; IFNA10; ATG13; IFNA5; IFNG1-2
mTOR signaling pathway
RPS6KA2; RRAGCA; EIF4E1B; ULK3; PIK3R2; RPS6KA1; DDIT4; PIK3R3B; AKT3A; ULK1
PIK-Akt signaling pathway
ITGA10; ITGB7; HSP90AA1; FGF4; LAMA3; PPP2CA; OSMR; FGFR4; GH1; TNXB
AMPK signaling pathway
ADIPOR2; PPP2R2D; PRKAA1; LEP; ADIPOQ; PPP2R2C; PPP2R5C; SLC2A4; CREB5; CRTC2
Regulation of actin cytoskeleton
PIP5K1AB; MYL9B; MYL12.2; ITGA5; PIP5KL1; HRASA; FGF20; SCINLA; CFL2; MAP2K1
Insulin signaling pathway
G6PCA.2; SOCS9; PPP1CAB; PPP1R3CB; MAPK8A; PRKAG1; ARAF; HRASA; FOXO1A; PRKAB1B
Insulin secretion
ATP1A4; KCNN2; KCNMA1; SNAP25; RYR2; ITPR3; CAMK2G; KCNMB1; ATP1B1; RIMS2
Ovarian steroidogenesis
FSHB; BMP15; Adcy4; HSD3B5; PTGS2; HSD17B1; FSHR; PLA2G4A; LDLR; GNAS
Progesterone-mediated oocyte maturation
RPS6KAL; ADCY1B; INSB; PIK3CA; MAPK1; ADCY1A; PRKACBA; CDC16; PIK3R2; FZR1
Prolactin signaling pathway
MAPK3; GSK3B; SHC3; ESR1; SOCS4; PIK3R3; SOCS3; MAPK1; SRC; MAPK8
Regulation of lipolysis in adipocytes
PTGS2; PIK3CD; INS; GNAI3; INS2; PLIN1; PRKACB; TSHB; TSHR; NPY1R
Type II diabetes mellitus
CACNA1G; PIK3CA; PIK3R3; PIK3CD; INS-IGF2; PRKCE; SLC2A2; PKM; INS1; PIK3CB
Insulin resistance
INSR; RPS6KA3A; MTOR; PIK3CA; GFPT1; PIK3R5; NFKBIAA; PPARA; PPARAB; PTPN1
Non-alcoholic fatty liver disease (NAFLD)
PIK3CG; NDUFA9; NDUFV3; NDUFS6; PRKAB1; PIK3R2; COX7A1; ADIPOQ; IRS2; NDUFA10
Type I diabetes mellitus
TNF; IL12B; HLA-DPB1; H2-AB1; HLA-DOA; HLA-DQA2; HLA-DPA1; HLA-G; FASLG; Il2
Maturity onset diabetes of the young
NEUROG3; INS1; PAX6; INS; HHEX; MAFA; HNF1B; PAX4; HNF1A; HNF4G
Aldosterone-regulated sodium reabsorption
ALPHA-ENAC; PDPK1; PIK3CB; FXYD2; SLC9A3R2; INS2; ATP1B2; INS1; IGF1; KRAS
Prostate cancer
NFKBIA; AKT2; KRAS; NKX3; BCL2; CREB5; SMARCA4; NRAS; TCF7; PIK3R3

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein SST2; FSD1; PPY; TTR; PRL5A1; PRL7C1; PTH1A; CRHR2; INSL5; GIP
Function identical protein binding
Related Protein NQO1; ITGA2B; S100B; CEP72; ESYT2; ADIPOQ; SMN1; AMOTL2; APPL1; CLDN7
Function insulin receptor binding
Related Protein PTPN1; SNX1; INS1; LMBRD1; PIK3R1; INS2; ENPP1; GRB10; DOK1; DOK7
Function insulin-like growth factor receptor binding
Related Protein PIK3R1; GNAS; IGF2A; SHC1; IGF1; YWHAH; SOCS2; Ren1; INS; IRS1
Function protease binding
Related Protein CNTNAP2; RFFL; DVL3; RNF139; PINK1; FLOT1; CFLAR; COMP; TIMP1; SERPINE1
Function protein complex binding
Related Protein SKAP1; PAFAH1B1; CCND1; LCK; OTOF; NFYB; YWHAB; VHLL; PRKACA; ANKRD32