ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RASSF5; AKT2; CALM2; PRKACB; PLA2G2D; RAPGEF5; RALB; SHOC2; PIK3R2; AKT1
Rap signaling pathway
FGF3; FGF2; PIK3R2; PLCB4; KRIT1; FGF20; CALM4; MAPK1; PRKD2; IGF1
cGMP-PKG signaling pathway
ROCK1; PLCB3; PRKG2; MEF2B; NPR1; VDAC2; PPP3R1; KCNMB3; CALM1; PIK3CA
HIF- signaling pathway
PIK3R5; INS; NOX3; HIF1A; EPO; AKT2; PGK1; STAT3; NOS2; LTBR
FoxO signaling pathway
IGF1R; SGK1; MAPK12; TGFB2; IKBKB; SOS1; PLK1; CDKN1BA; S1PR4; KLF2
Phospholipase D signaling pathway
DGKD; MAP2K1; PIK3CA; MRAS; IL-8; PDGFRB; PLCB2; INSR; TSC2; CYTH4
Oocyte meiosis
CPEB1A; Ar; CDC26; INS1; PRKACB; CAMK2D; PPP2R5E; STAG3; MOS; PPP3CB
Regulation of autophagy
IFNPHI3; IFNA21; IFNA5; IFNA7; PIK3C3; ATG13; IFNA8; IFNG; INS; ATG12
mTOR signaling pathway
RICTOR; EIF4E2RS1; EIF4BA; PDPK1; RPTOR; BRAF; EIF4E1B; PTEN; PRR5; STRADA
PIK-Akt signaling pathway
TNC; COL24A1; PDGFRB; TCL1; LPAR5; IFNA1; IFNA13; EPOR; COL4A1; LAMA4
AMPK signaling pathway
MAP3K7; RAB11B; GYS1; CCND1; FOXO3; MTOR; CAB39; Scd2; ELAVL1; PIK3R2
Regulation of actin cytoskeleton
FGF9; ITGB1A; RHOAD; RHOAB; CHRM5B; FGF3; SCIN; SCINLB; PIP4K2C; ITGA6B
Insulin signaling pathway
PRKACG; RAPGEF1B; PIK3R3; PRKAR1B; INPP5K; SHC3; BADB; PPP1CAB; HKDC1; CALM1B
Insulin secretion
ATP1A3; KCNMB2; ATP1B4; ATP1A1; GCG; VAMP2; CREB3L1; SNAP25; FFAR1; ATP1B1
Ovarian steroidogenesis
PTGS2; BMP6; STAR; HSD3B4; SCARB1; INS; LHCGR; IGF1; PLA2G4C; HSD17B7
Progesterone-mediated oocyte maturation
CDC25A; RAF1B; RPS6KA3B; CDC26; MAD2L2; MAPK10; SPDYB; PRKACAB; CCNB3; Adcy4
Prolactin signaling pathway
SOCS2; SOS1; IRF1; CCND1; MAPK9; NRAS; PPIB; INS; AKT1; MAPK11
Regulation of lipolysis in adipocytes
LIPE; PTGS1; NPR1; PTGS2; PRKG1; PRKG2; PIK3R2; AKT2; NPY; PIK3R3
Type II diabetes mellitus
PIK3R3; IRS2; SOCS3; INSR; SLC2A4; PRKCD; HK3; MAPK8; ADIPOQ; MAPK10
Insulin resistance
PYGB; PPARGC1B; PIK3R2; INS2; TNFRSF1A; RPS6KA1; SLC2A1A; SREBF1; PPP1R3C; PTPRFB
Non-alcoholic fatty liver disease (NAFLD)
NDUFC2-KCTD14; COX7A1; LEP; BAX; SDHC; SOCS3; PIK3CA; NR1H3; PIK3CG; CASP7
Type I diabetes mellitus
TNF; H2-Q10; HLA-DRA; FAS; HLA-DRB4; INS; HLA-F; GZMB; HLA-DOA; IL1A
Maturity onset diabetes of the young
NKX6; NKX6-1; PKLR; NEUROD1; INS2; HNF4A; BHLHA15; HNF1B; RFX6; PAX6
Aldosterone-regulated sodium reabsorption
ATP1B2; ATP1A2; INSR; IRS1; SGK1; INS; ATP1B4; PIK3CD; ATP1A4; HSD11B2
Prostate cancer
NKX3; PTEN; MDM2; PIK3CB; CREB5; CCND1; BRAF; NFKB1; INS2; SRD5A2

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein MLN; LEPB; SST; INS2; STC2; GNRH3; GPHA2; VIP; PYY; PRL7A1
Function identical protein binding
Related Protein SNX1; MBIP; COL1A1; DPP4; SYT9; PLIN5; PTPRG; PTS; LYZ; G6PD
Function insulin receptor binding
Related Protein PDPK1; PTPN1; DOK1B; INSL3; LMBRD1; IGF1R; SNX2; IRS4; IGF2; ENPP1
Function insulin-like growth factor receptor binding
Related Protein Ren1; INS2; SHC1; YWHAH; INS; YWHAG; IGF2B; IGF2; IRS1; PIK3R1
Function protease binding
Related Protein FADD; PINK1; FAP; A2M; TRIP4; POLG; IL1R1; TRP53; CHL1; ADAMTS4
Function protein complex binding
Related Protein PPP4C; LCK; CALY; DAG1; ANKRD54; CALCA; KAT2B; ATF1; INS2; Apba1