ins2
Share
  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
+Inquiry
Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
+Inquiry

Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
MAPK10; MET; GNG11; FGFR3; GNB2; RALB; FGF13; ETS1; ETS2; HRAS
Rap signaling pathway
PRKCA; IGF1; FGF18; RAPGEF1; RAC3; PFN3; FGF10; FGF13; PARD6A; F2R
cGMP-PKG signaling pathway
PDE5A; CALM1; ROCK2; ATP2A1; TRPC6; CREB5; PLCB4; ATP1B4; NFATC3; PLCB3
HIF- signaling pathway
ENO2; IFNGR2; PIK3CD; NOX1; CAMK2A; PIK3R5; PIK3R1; PFKL; STAT3; NOX3
FoxO signaling pathway
PTEN; IGF1RB; MAP2K2A; AGAP2; RAF1B; KRAS; PRKAA2; RBL2; SMAD3; INSRA
Phospholipase D signaling pathway
PLCB4; INS; PLA2G4D; PLCG2; GRM7; MAP2K1; GAB2; DGKE; SPHK1; AGTR1B
Oocyte meiosis
RPS6KA1; CCNB2; YWHAE2; ESPL1; PPP3CCA; INS1; PPP1CB; IGF1; PPP2R5A; CDC25C
Regulation of autophagy
INS2; ATG10; Ifna11; IFNG1-2; IFNA6; IFNA21; IFNA5; IFNA8; IFNA13; IFNA1
mTOR signaling pathway
TSC1; PIK3R3; EIF4BA; BRAF; RPS6KA2; RRAGD; PTENA; AKT3A; ULK1; EIF4E2
PIK-Akt signaling pathway
MAPK3; THBS4; ITGA9; ITGA2; LAMA2; CREB3L1; PIK3R3; PRKAA1; Ifna15; IL4R
AMPK signaling pathway
TBC1D1; SLC2A4; PRKAB1; PPP2R5B; CAMKK2; PPP2R3A; LIPE; CCNA2; PIK3CD; RAB8A
Regulation of actin cytoskeleton
ROCK1; CD14; Itga10&Itgb1; FGF22; PIK3R1; PIK3R3B; ARPC4L; FGF20B; FGF13B; WASLA
Insulin signaling pathway
SREBF1; MAPK9; HRASA; IRS2; RPS6KB1B; INSR; FLOT2B; PYGM; BAD; PYGL
Insulin secretion
PRKCG; Adcy4; KCNN2; RIMS2; GPR119; ITPR3; RYR2; PRKACG; PRKACA; SNAP25
Ovarian steroidogenesis
PRKACB; CYP2J6; STAR; HSD3B4; INS1; GNAS; HSD3B6; PLA2G4C; ALOX5; FSHR
Progesterone-mediated oocyte maturation
RPS6KA2; KRAS; MAD1L1; PRKACAB; PRKACG; CDC16; MAPK8A; ANAPC7; CPEB1B; SPDYA
Prolactin signaling pathway
NFKB1; PIK3R3; HRAS; FOXO3; ESR2; NEK3; STAT5A; MAPK10; SHC2; SHC1
Regulation of lipolysis in adipocytes
PIK3R2; NPR1; TSHR; INS2; PTGER3; PLIN1; PTGS2; PRKG2; PRKACA; PIK3CD
Type II diabetes mellitus
MAPK9; PIK3R3; MTOR; HKDC1; PIK3R2; SOCS1; PIK3CA; PIK3CG; HK2; MAPK1
Insulin resistance
INSRB; PPP1CAB; PIK3CD; PPP1CC; AKT2L; CREB3L2; RPS6KA1; CREB3L3A; TNFRSF1A; SLC27A2
Non-alcoholic fatty liver disease (NAFLD)
COX8C; NDUFA2; PIK3CG; PRKAB1; NDUFA12; COX7B; NFKB1; AKT1; MAP3K5; COX4I2
Type I diabetes mellitus
HLA-DQB1; H2-Q10; HLA-DPB1; IL1B; GAD2; INS2; H2-AA; HLA-DRB4; ICA1; HLA-DOB
Maturity onset diabetes of the young
NR5A2; ONECUT1; HES1; MNX1; HHEX; HNF4A; HNF4G; PDX1; NEUROG3; IAPP
Aldosterone-regulated sodium reabsorption
HSD11B2; SCNN1B; SGK1; MAPK1; PRKCA; IRS1; PIK3R2; ATP1A3; PIK3CG; INS
Prostate cancer
MAP4K1; FOXA1; TGFA; PIK3CG; CREB5; LEF1; ARID1A; PIK3CD; CREB3L3; INS

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein UTS2; INHBE; UTS2A; ADM; SCT; PTH1B; FSD1; MLN; FNDC5; INHBB
Function identical protein binding
Related Protein BIN1; ERN1; L3MBTL1; NEFL; DYNLT1; THG1L; UBE4A; EPHA4; HCN2; PKD2L1
Function insulin receptor binding
Related Protein IGF2; PHIP; INS; INS1; DOK1B; LMBRD1; DOK5; DOK6; IRS4; SNX1
Function insulin-like growth factor receptor binding
Related Protein YWHAH; IRS1; INSL4; REN; SOCS2; IGF2A; YWHAG; IGF3; IGF2B; ARRB1
Function protease binding
Related Protein SERPINA1D; ALPI; STIM1; SELL; PANX1; TIMP4; TP53; LDLR; RNF139; RYR1
Function protein complex binding
Related Protein Ctsl; TULP2; COG2; ATG101; SH2B3; WASF1; ING2; VPS28; RIPK1; DRD1A