ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PLA2G4A; FGF17; FGF14; GNG4; PLA2G2E; FGF10; PLA2G2F; KITLG; TEK; NGF
Rap signaling pathway
PLCG1; NRAS; CALM2; KRAS; PDGFRA; ITGA2B; TEK; PARD6B; FGF21; FGFR3
cGMP-PKG signaling pathway
VASP; CALM3; VDAC1; ATP2B4; PDE2A; PDE3B; ATP1B2; MEF2D; GATA4; SLC8A1
HIF- signaling pathway
PRKCG; TIMP1; PRKCA; EIF4E2; NOS2; NOX3; IGF1R; Trf; ARNT; HKDC1
FoxO signaling pathway
ATM; CCNG2; SGK2B; GADD45AB; RAF1; PRKAB2; TGFB1; EGFRA; PLK2; INSRA
Phospholipase D signaling pathway
SHC3; PIK3CA; RHOA; GAB1; AGTR1A; GNA12; HRAS; PLD1; TSC2; INS
Oocyte meiosis
RPS6KA1; RPS6KA3A; CALM3A; SMC1B; RPS6KA3B; CALM1B; CUL1A; YWHAG; PLCZ1; PRKACA
Regulation of autophagy
PRKAA1; Ifna11; IFNA16; ATG16L1; ATG4C; GABARAPA; IFNPHI1; GABARAP; ATG5; IFNA4
mTOR signaling pathway
EIF4BB; RB1CC1; DEPDC6; ULK1; RRN3; TNF; EIF4E2RS1; PRKCA; INS2; IRS1
PIK-Akt signaling pathway
IGF1R; MAPK1; GNG2; FGFR2; TNC; KITLG; PPP2R2B; MAP2K1; FGFR4; IRS1
AMPK signaling pathway
PRKAA1; PPP2R3A; CREB1; GYS1; Scd1; ACACA; PIK3R3; IRS4; SLC2A4; PPARGC1A
Regulation of actin cytoskeleton
MYL10; RAF1A; MYL12.2; PIK3R2; ARHGEF7B; PPP1R12C; MAPK6; ITGA4; MYL1; APC
Insulin signaling pathway
PPP1CB; MAPK9; FBP1A; HRASB; NRAS; HK2; FASN; HK1; GYS2; SHC2
Insulin secretion
PRKACG; RYR2; ATP1A2; PDX1; GNAS; KCNN3; KCNJ11; GCG; INS; CAMK2G
Ovarian steroidogenesis
PLA2G4D; AKR1C3; HSD3B6; HSD3B1; PRKACG; PRKACA; INSR; PTGS2; HSD3B4; SCARB1
Progesterone-mediated oocyte maturation
PIK3R3A; MAPK8; RPS6KA1; RAF1B; MAPK3; HSP90AB1; ANAPC1; INSB; CCNA2; KRAS
Prolactin signaling pathway
STAT5B; PRLR; HRAS; GSK3B; TH; AKT1; PIK3CG; SOCS6; SOCS2; ELF5
Regulation of lipolysis in adipocytes
PRKACB; LIPE; PRKACG; NPR1; PIK3CD; NPY1R; ABHD5; GNAI1; GNAS; GNAI2
Type II diabetes mellitus
HK1; HK3; HKDC1; PRKCD; PKLR; PRKCE; TNF; PDX1; INS-IGF2; PRKCZ
Insulin resistance
IRS2; SOCS3B; CREB3L3; PPP1R3C; FOXO1B; OGT; FOXO1A; PRKAG1; PDPK1; INS
Non-alcoholic fatty liver disease (NAFLD)
CDC42; COX7A1; UQCR11; AKT2; ADIPOQ; MLXIPL; BID; SDHC; TGFB1; NDUFA6
Type I diabetes mellitus
HLA-DRB3; PRF1; H2-Q10; INS; LTA; CPE; H2-AB1; HLA-DRB1; FASLG; HLA-F
Maturity onset diabetes of the young
NEUROG3; SLC2A2; NEUROD1; PAX4; FOXA2; PKLR; PAX6; HNF1A; NKX6-1; ONECUT1
Aldosterone-regulated sodium reabsorption
FXYD2; INS; SCNN1G; HSD11B2; FXYD4; PIK3R1; SLC9A3R2; PIK3R3; NEDD4L; PRKCA
Prostate cancer
SOS1; FOXO1; GSK3B; ACTL6B; PIK3CD; RB1; PDPK1; CCNE2; SPINK1; PDGFRA

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein PRL; PRL2A1; ADCYAP1A; METRNL; SMTLA; GPHB5; INHBAB; IGF3; GCG; GUCA2A
Function identical protein binding
Related Protein ALK; DYNLT1; IGF2R; THBS1; DLC; S100A2; JMJD6; TPRG1L; PRDX3; RILPL2
Function insulin receptor binding
Related Protein IGF1R; DOK1B; PDPK1; FRS2B; DOK3; INS2; SHC1; DOK5; GRB10; FRS2
Function insulin-like growth factor receptor binding
Related Protein Ren1; IGF2A; INSR; IGF2B; IGF3; INSL4; SOCS2; ARRB1; PIK3R1; INS2
Function protease binding
Related Protein FURIN; TIMP4; POLG; CSTA; THAP5; CD70; TNF; HSPA6; ADAMTSL4; BRCA2
Function protein complex binding
Related Protein UQCRC2; SLC27A5; FGFR1; ABI1; PDZK1; LEPRE1; CDK5RAP1; CDK2; CALY; STRN4