ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
GNG3; SHC2; PLA1A; FGF16; FIGF; MAPK10; TBK1; PLA2G2E; PLCG1; PLA2G2D
Rap signaling pathway
FGF4; FLT1; DOCK4; PLCB4; RAPGEF6; ITGB1; PRKD1; RAC1; BRAF; PARD6B
cGMP-PKG signaling pathway
SRF; NFATC2; PDE3A; PLCB4; PIK3CD; SLC25A5; INS; GUCY1B3; PRKCE; MAP2K1
HIF- signaling pathway
PIK3CA; PDHB; ALDOA; LDHA; EGLN1; IFNGR1; ANGPT4; MAPK3; PIK3CD; HMOX1
FoxO signaling pathway
PIK3R5; KLF2; INSRA; RBL2; RAF1; PIK3CG; HOMER2; FOXO1A; SMAD2; PRKAG3
Phospholipase D signaling pathway
AVPR2; DGKZ; DNM3; PDGFD; CXCR1; PLCB3; DGKE; LPAR2; TSC1; PLA2G4C
Oocyte meiosis
CAMK2B; PPP2R5E; CALM3B; ITPR3; PKMYT1; ANAPC5; RPS6KA1; ADCY1A; MAD2L1; PPP1CC
Regulation of autophagy
INSB; IFNA21; IFNA16; ATG4C; IFNA1; IFNA14; ULK2; INS2; ATG10; INS1
mTOR signaling pathway
RPS6KB1; PRKCBB; AKT1; PRKAA2; PTENA; RPS6KA6; DEPDC6; AKT1S1; EIF4BB; PRKCBA
PIK-Akt signaling pathway
IFNA5; PDPK1; THBS4; ANGPT1; FOXO3; Fgf15; PRLR; IFNA2; FIGF; ITGA6
AMPK signaling pathway
RPS6KB2; AKT1S1; PPP2R1A; PIK3R2; GYS2; SCD; EIF4EBP1; CREB3L2; PDPK1; CFTR
Regulation of actin cytoskeleton
ARHGEF7A; F2; VAV1; FGF7; ITGB3B; GSN; MLCK2; FGF9; INSB; PIP4K2A
Insulin signaling pathway
PRKAB1A; CALM; MAPK1; FLOT2B; CBLC; FOXO1B; PRKAG2A; PHKB; AKT2L; CALM2
Insulin secretion
GPR119; RAB3A; KCNN3; GNA11; ITPR3; SLC2A2; ATP1A4; GCG; CREB5; PRKACA
Ovarian steroidogenesis
HSD17B1; HSD3B5; HSD3B2; HSD17B2; BMP15; INSR; PRKACB; PRKACG; PLA2G4D; Adcy4
Progesterone-mediated oocyte maturation
PDE3B; ANAPC2; PGR; PRKACG; MAD2L1; CDC23; PRKACBB; MAPK1; MAPK8B; ADCY1A
Prolactin signaling pathway
CCND2; NEK3; TNFRSF11A; TNFSF11; SHC4; MAPK8; SOCS7; STAT1; MAPK13; STAT5B
Regulation of lipolysis in adipocytes
PRKG1; FABP4; AKT1; NPY1R; PIK3CD; LOC100328615; INSR; AQP7; NPR1; PTGS1
Type II diabetes mellitus
ADIPOQ; INSR; CACNA1G; INS; IRS4; HK2; PIK3R2; PIK3R1; PIK3R3; MAPK10
Insulin resistance
PRKCBA; G6PC3; GFPT2; CREB3L1; GYS1; PYGB; PIK3R3A; PPP1CAB; SLC2A4; PYGL
Non-alcoholic fatty liver disease (NAFLD)
NDUFS6; PIK3CG; NDUFS5; NDUFS2; UQCR10; NDUFB8; CYCS; NDUFC2-KCTD14; NDUFA3; AKT1
Type I diabetes mellitus
CD80; HLA-DRA; HLA-DOA; HLA-B; Il2; H2-AA; ICA1; GZMB; HLA-E; LTA
Maturity onset diabetes of the young
ONECUT1; NR5A2; HNF4G; INS1; PAX6; PDX1; HNF4A; NEUROG3; HES1; RFX6
Aldosterone-regulated sodium reabsorption
PIK3R1; ATP1A3; PIK3R3; PRKCB; PIK3CG; PIK3CB; KCNJ1; SCNN1B; PRKCG; SFN
Prostate cancer
PIK3R2; RB1; NRAS; PIK3CD; SMARCD1; MDM2; INS2; MTOR; GRB2; PIK3R3

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein CSH2; FNDC5B; CRHR2; IAPP; PRL8A9; GAST; STC1; GH2; RLN3A; ADCYAP1A
Function identical protein binding
Related Protein LZTFL1; HCFC1; CCL4; ZHX2; DCP1A; VEGFA; CEP57L1; DVL2; BAIAP2; INS
Function insulin receptor binding
Related Protein FRS2A; SNX1; INS; IRS1; ENPP1; DOK1B; IGF2; DOK6; DOK7; INSL3
Function insulin-like growth factor receptor binding
Related Protein SOCS2; INS2; ARRB1; INSR; REN; IGF2A; IRS1; GNAS; IGF1; YWHAH
Function protease binding
Related Protein Casp3; HSPA6; SRI; CSTA; OS9; RYR1; CST3; FLOT2; TNFAIP3; POLG
Function protein complex binding
Related Protein EP300; CAV3; ATP6V1B1; CDH2; PPP4C; AP2A1; KRT8; DISC1; C8B; LEPRE1