ins2
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  • Official Full Name
  • insulin 2
  • Synonyms
  • INS2;insulin 2;insulin-2;
Cat.#:INS2-8234MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INS2 Protein
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Cat.#:INS2-3077RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INS2 Protein
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Involved Pathway

Ins2 involved in several pathways and played different roles in them. We selected most pathways Ins2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ins2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
PAK7; GNGT1; SHC1; RHOA; RASAL2; CALM4; REL; RAF1; STK4; FGF4
Rap signaling pathway
PIK3CD; SIPA1L1; FPR1; RAC1; GNAI2; PIK3CG; RAPGEF6; PDGFB; PIK3R2; FGF12
cGMP-PKG signaling pathway
INS2; PRKG1; ROCK2; PIK3R1; IRS4; ATF4; PPP1CC; ITPR3; SLC8A1; PDE3A
HIF- signaling pathway
ENO1; IGF1R; STAT3; MKNK2; SERPINE1; PRKCA; IGF1; NOS3; RPS6KB2; PFKL
FoxO signaling pathway
G6PC2; SMAD4; HRASA; GRB2; G6PC3; AKT3A; CDKN2B; BNIP4; INS2; SOS1
Phospholipase D signaling pathway
PLA2G4C; MS4A2; MAPK3; PLA2G4D; PLA2G4A; ARF6; SHC3; Adcy4; DGKZ; LPAR6
Oocyte meiosis
CALM2; PRKACBA; CDC20; CALM2B; CUL1B; CPEB1A; YWHAQA; RPS6KA2; REC8B; PRKACAA
Regulation of autophagy
IFNPHI1; PIK3R4; GABARAPL2; IFNA21; ATG16L1; BECN1; Ifna15; ULK2; ATG14; IFNA1
mTOR signaling pathway
AKT2; TSC1; PRKCG; PRKAA2; MTOR; VEGFA; RB1CC1; HIF1A; INSB; PRKCA
PIK-Akt signaling pathway
PPP2R5D; LAMC1; G6PC2; FGF14; PPP2R5C; PDGFB; COL6A4; TNC; IL6R; PDGFA
AMPK signaling pathway
PPP2R2C; ADIPOR1; PPARG; LIPE; FBP1; RPS6KB2; PPP2R2B; PPP2R5B; CFTR; PIK3CA
Regulation of actin cytoskeleton
FGFR3; MAP2K2A; MYH9; RHOAB; PIK3CB; RAF1B; SCINLB; PDGFC; ROCK2A; ARHGEF6
Insulin signaling pathway
HRAS; SLC2A4; SHC1; KRAS; ACACA; LIPE; NRAS; PRKAG2A; BADB; MAP2K1
Insulin secretion
INS; ATP1B3; PDX1; STX1A; PLCB4; SLC2A1; CAMK2D; CREB5; KCNMB1; KCNMA1
Ovarian steroidogenesis
GDF9; CYP2J6; INS; HSD3B2; ALOX5; Adcy4; LDLR; FSHR; PLA2G4A; STAR
Progesterone-mediated oocyte maturation
ARAF; CPEB2; INS2; Adcy4; MAPK3; BUB1; GNAI1; ADCY2B; CCNB1; MAD2L2
Prolactin signaling pathway
MAPK1; PIK3CB; STAT5B; MAPK8; PRP2; SIRPA; PPIB; PIK3CG; MAPK13; GALT
Regulation of lipolysis in adipocytes
PLIN1; PNPLA2; LIPE; PDE3B; NPY; PTGS1; GNAI2; PRKACA; PIK3R5; LOC100328615
Type II diabetes mellitus
MAPK3; CACNA1G; MTOR; PDX1; IRS4; PIK3CD; INS2; PIK3CB; PIK3R5; PKLR
Insulin resistance
PPP1R3C; SLC27A4; CREB5; PIK3R2; CREB1A; PIK3R3A; RPS6KA3A; PPP1CC; PPP1R3DA; PRKCBA
Non-alcoholic fatty liver disease (NAFLD)
MAP3K11; COX7A2L; UQCRC2; NR1H3; EIF2AK3; GSK3A; TNFRSF1A; ADIPOR2; INSR; RELA
Type I diabetes mellitus
HLA-DQA1; IL12B; IL1A; HLA-DRB4; INS1; HLA-C; HLA-DRB3; HLA-DPA1; FAS; Il2
Maturity onset diabetes of the young
INS; NR5A2; HES1; FOXA3; NEUROG3; NKX6-1; SLC2A2; PDX1; HNF1B; MAFA
Aldosterone-regulated sodium reabsorption
ATP1A1; ATP1A4; PRKCA; SLC9A3R2; SCNN1G; PRKCB; SCNN1B; ATP1B4; INS2; NEDD4L
Prostate cancer
NFKB1; GRB2; PDPK1; ATF4; AKT1; IKBKG; CCNE1; MAP2K2; Ar; PTEN

Protein Function

Ins2 has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ins2 itself. We selected most functions Ins2 had, and list some proteins which have the same functions with Ins2. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein ADIPOQ; AVP; NPPC; FNDC5; EDN2; LHB; GPHB5; POMCA; INSL3; INHBC
Function identical protein binding
Related Protein GOT1; UBE4A; AXIN1; ST13; ALCAMA; PRDX3; KHDRBS1; DAPK2; APP; DACT3
Function insulin receptor binding
Related Protein SNX4; SHC1; GRB10; DOK1B; SLC2A2; PHIP; INS1; ENPP1; SNX1; IGF1R
Function insulin-like growth factor receptor binding
Related Protein YWHAH; PIK3R1; IGF1; REN; IGF2B; IRS1; INS; SOCS2; IGF2A; IGF3
Function protease binding
Related Protein TNF; POLG; LCN2; KIT; ADRM1; FURIN; NFRKB; ITGA3; VWF; TRP53
Function protein complex binding
Related Protein CAPG; SKIL; TRAF2; TULP2; PPIB; DISC1; THRA; UQCRFS1; ST13; TELO2