kalrn
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  • Official Full Name
  • kalirin, RhoGEF kinase
  • Background
  • Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • KALRN; kalirin, RhoGEF kinase; HAPIP, huntingtin associated protein interacting protein (duo); kalirin; ARHGEF24; DUET; duo; Hs.8004; serine/threonine kinase with Dbl and pleckstrin homology domains; TRAD; huntingtin-associated protein interacti
Cat.#:KALRN-8442MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KALRN Protein
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Cat.#:KALRN-3150RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KALRN Protein
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Involved Pathway

KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EPHB4; FGF8B; EPHA3; FRS2A; CSNK2B; ARPC1A; PAK6; SEMA7A; PSPN; SPNA1
Cell death signalling via NRAGE, NRIF and NADE
NET1; KALRNB; ARHGEF3; PLEKHG2; ABR; ARHGEF18; CASP2; MCF2L; OBSCN; ECT2
Developmental Biology
SEMA3A; SCN3B; CNKSR1; DUSP4; TCF12; NRG4; COL4A3; LGI1A; ADAM22; SCN9A
EPH-Ephrin signaling
ARHGEF28; EPHA10; EPHA4A; MYL9; ARPC1A; ARPC2; EFNA4; ARPC5; EFNB1; CFL1
EPHB-mediated forward signaling
ACTR3; EPHB4A; EFNB3B; ARPC1A; ARHGEF28; KALRNB; ARPC1B; ITSN1; EPHB4B; EPHB3A
G alpha (12/13) signalling events
ARHGEF18; NET1; RHOB; ARHGEF16; ITSN1; ARHGAP4; TRIO; RHOAE; ECT2; OBSCN
G alpha (q) signalling events
NTS; OPN4.1; AGT; ADRA1D; ANXA1; FPR-RS6; NPSR1; DGKG; TAC2; FPR-RS4
GPCR downstream signaling
CHRM2; CHRM3; PLEKHG2; RGS20; CALCRL; EDNRA; UTS2; ADM2A; SST; AKAP13

Protein Function

KALRN has several biochemical functions, for example, ATP binding, Rho guanyl-nucleotide exchange factor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ORC4L; ABCB6; ABCG3; KIF2A; ACSL4; APAF1; DMPK; LIG3; TSSK4; AK7B
Function Rho guanyl-nucleotide exchange factor activity
Related Protein ARHGEF2; FGD2; RASGRF2B; ARHGEF7; ARHGEF1A; ITSN2A; PLEKHG3; ARHGEF33; FGD; DNMBP
Function enzyme binding
Related Protein RCOR2; PPP1R3B; DYM; CD4; EIF4E; CA; PEX5; HSPA2; TOP2B; POLB
Function guanyl-nucleotide exchange factor activity
Related Protein ITSN2A; TBC1D10A; TBXA2R; FGD3; SPATA13; FGD1; RASGEF1BA; BCAR3; RAPGEF3; ARHGEF7A
Function kinase activity
Related Protein CAMK2B1; GRK1A; ERBB4A; MAPK8A; WNK2; EGFRA; EPHA4B; NMRK2; BMPR2B; NTRK2B
Function metal ion binding
Related Protein ERMP1; RARAA; OVCH2; COL18A1; SALL3B; SMPD2; ING5A; RHO; RNF144AA; KCNIP3B
Function nucleotide binding
Related Protein ENOX2; PPIP5K2; MKI67IP; UBE2D1B; ELAVL2; EEF1A1B; EPHB2B; ARL4CB; GNAI2A; ERBB4A
Function protein kinase activity
Related Protein RPS6KA3; CDK8; PHKG1A; SOX9; BMPR1BB; PRKACAA; GUCY2C; IKBKB; STK25B; STK24A
Function protein serine/threonine kinase activity
Related Protein CDC42BPA; SGK2; PAK6; MYO3A; EIF2AK2; DAPK3; STK16; STK32A; DCKL1B; ULK4
Function transferase activity
Related Protein MAPKAPK2B; PRKG1A; DIMT1; NAT14; ZDHHC16B; GSK3AB; CHATA; GYG1B; PIP5K1AA; RFNG

Interacting Protein

KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.
HAP1; Sncaip; Grin1; Grin2b; Dlg4; Ywhab