KCNA1 Protein, potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)


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Official Full Name potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Background This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
Synonyms KCNA1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1; potassium voltage-gated channel subfamily A member 1; voltage-gated K(+) channel HuKI; voltage-gated potassium channel HBK1; voltage-gated potassium channel subunit Kv1.1;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KCNA1-01H Recombinant Human KCNA1 Protein, GST-tagged Wheat Germ GST
    Human KCNA1-592H Recombinant Human KCNA1 Protein (1-154 aa), His-tagged E.coli His
    Human KCNA1-29199TH Recombinant Human KCNA1 Wheat Germ N/A
    Human KCNA1-5079HCL Recombinant Human KCNA1 293 Cell Lysate HEK293 N/A
    Mouse KCNA1-8470M Recombinant Mouse KCNA1 Protein Mammalian Cell His
    Rat KCNA1-3164R Recombinant Rat KCNA1 Protein Mammalian Cell His

    KCNA1 involved in several pathways and played different roles in them. We selected most pathways KCNA1 participated on our site, such as Neuronal System, Potassium Channels, Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuronal System NSFB; KCNB1; KCNJ1A.3; KCNH1; KCNMB1; SLC18A3A; SYT1A; KCNQ3; KCNC1B; KCNAB3
    Potassium Channels KCNN1B; KCNC1; KCNN1A; KCNMB2; KCNB2; KCNK13A; KCNC2; KCNK7; KCNJ8; KCNJ1A.4
    Voltage gated Potassium channels KCNC2; KCNF1A; KCNH5; KCNC4; KCNV1; KCNG3; KCNA1; KCNH5A; KCNH1B; KCNH1

    KCNA1 has several biochemical functions, for example, delayed rectifier potassium channel activity, potassium channel activity, potassium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA1 itself. We selected most functions KCNA1 had, and list some proteins which have the same functions with KCNA1. You can find most of the proteins on our site.

    Function Related Protein
    delayed rectifier potassium channel activity KCNC1A; KCNQ1; KCNA2; KCNC3A; KCNC1B; KCNS2; KCNF1; KCNB1; KCNQ2; KCNA2B
    potassium channel activity KCNK1A; KCNC4; FXYD4; KCNF1A; KCNC1B; KCNH5; KCNS3A; KCNC2; KCNJ11L; KCNK10
    potassium ion transmembrane transporter activity AQP1; KCNA1
    protein binding ATG101; RRAD; HTT; TSTD2; KLF12; PTRH1; ISG15; PIBF1; SERPINA1; POU3F3
    voltage-gated potassium channel activity CNGA2; KCNH8; KCNQ1; CNGA3; KCNG4A; HCN2; KCNA4; KCNC1A; KCNS3A; KCNC1B

    KCNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA1.

    DLG4; Dlg4; Dlg3

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