KCNA1
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Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
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Overview
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008] -
Synonyms
KCNA1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1; potassium voltage-gated channel subfamily A member 1; voltage-gated K(+) channel HuKI; voltage-gated potassium channel HBK1; voltage-gated potassium channel subunit Kv1.1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
KCNA1 involved in several pathways and played different roles in them. We selected most pathways KCNA1 participated on our site, such as Neuronal System, Potassium Channels, Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | SLC6A11;SYN1;SLC1A7B;NCALDA;KCNJ11;STXBP1A;KCNK6;KCNQ3;KCNJ1A.5 |
| Potassium Channels | KCNK1;KCNS3;KCNK2B;KCNC1;KCNG4A;KCNV2;KCNAB2;KCNA2;KCNAB2B |
| Voltage gated Potassium channels | KCNH5A;KCNS3;KCNH1A;KCNG4A;KCNH6;KCNV1;KCNA2B;KCNH1;KCNC3A |
KCNA1 has several biochemical functions, for example, delayed rectifier potassium channel activity, potassium channel activity, potassium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA1 itself. We selected most functions KCNA1 had, and list some proteins which have the same functions with KCNA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| delayed rectifier potassium channel activity | KCNC1A;KCNA6A;KCNH1;KCNA2B;KCNC3B;KCNH2;KCNF1;KCND1;KCNG2 |
| potassium channel activity | KCNK18;KCNK4;KCNS3A;KCNA6A;KCNF1A;FXYD4;KCNA1;KCNC1A;KCNC3A |
| potassium ion transmembrane transporter activity | AQP1;KCNA1 |
| protein binding | TNS1;GORAB;GATAD2B;CARF;FOXO3B;CCDC41;TRIM13;TNFSF12;GYPB |
| voltage-gated potassium channel activity | KCNB2;KCNAB2;KCNH1B;CNGA5;KCNS3B;KCNQ1;HCN2;KCNH2;KCNA2B |
KCNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA1.
DLG4; Dlg4; Dlg3
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