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KCNA6

Official Full Name

potassium voltage-gated channel, shaker-related subfamily, member 6
Overview

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]
Synonyms

KCNA6; potassium voltage-gated channel, shaker-related subfamily, member 6; HBK2; KV1.6; potassium voltage-gated channel subfamily A member 6; human brain potassium channel-2; voltage-gated potassium channel HBK2; voltage-gated potassium channel protein Kv1.6; voltage-gated potassium channel subunit Kv1.6;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Rattus norvegicus (Rat)

Source

E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KCNA6-353HCL	Recombinant Human KCNA6 lysate	HEK293	N/A		Inquiry
Mouse	KCNA6-8476M	Recombinant Mouse KCNA6 Protein	Mammalian Cell	His		Inquiry
Mouse	KCNA6-4719M	Recombinant Mouse KCNA6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	KCNA6-4719M-B	Recombinant Mouse KCNA6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL31838HF	Recombinant Full Length Human Potassium Voltage-Gated Channel Subfamily A Member 6(Kcna6) Protein, His-Tagged	E.coli expression system	His	Full Length (1-529)	Inquiry
Mus musculus (Mouse)	RFL6983MF	Recombinant Full Length Mouse Potassium Voltage-Gated Channel Subfamily A Member 6(Kcna6) Protein, His-Tagged	E.coli expression system	His	Full Length (1-529)	Inquiry
Rattus norvegicus (Rat)	RFL13064RF	Recombinant Full Length Rat Potassium Voltage-Gated Channel Subfamily A Member 6(Kcna6) Protein, His-Tagged	E.coli expression system	His	Full Length (1-530)	Inquiry

Involved Pathway
Protein Function
Interacting Protein

KCNA6 involved in several pathways and played different roles in them. We selected most pathways KCNA6 participated on our site, such as Metabolism of proteins, Neuronal System, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of proteins	EXOC5;TBCA;IGFBP2B;WDR85;KLHDC3;ARSF;EEF1A2;TIMM10;LTF
Neuronal System	NSFA;KCNS2;KCNA2B;KCNJ1A.6;RAB3AB;KCNC1A;KCNS3A;DDX1;SLC6A12
O-linked glycosylation	ADAMTSL3;ADAMTSL5;SPON1;A4GNT;GALNT6;ADAMTS4;ADAMTSL1;B3GNT8;B3GALTL
O-linked glycosylation of mucins	MUC5AC;GALNTL5;GALNT13;GALNT5;B3GNT6;MUC21;B3GNT2A;MUC20;MUC1
Post-translational protein modification	MCFD2;ALG10B;YKT6;ADAMTS4;GALNT5;ADAMTS1;MGAT4A;NSMCE2;CNIH3
Potassium Channels	KCNN1A;KCNK10B;KCNN1;KCNV1;KCNQ2A;KCNN1B;KCNK7;KCNQ2;KCNJ1A.3
Voltage gated Potassium channels	KCNS2;KCND2;KCNA5;KCNA10;KCNF1;KCNAB3;KCNH2A;KCNH8;KCNAB2

KCNA6 has several biochemical functions, for example, delayed rectifier potassium channel activity, voltage-gated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA6 itself. We selected most functions KCNA6 had, and list some proteins which have the same functions with KCNA6. You can find most of the proteins on our site.

Function	Related Protein
delayed rectifier potassium channel activity	KCNC1;KCNC1A;KCNA2B;KCNA10;KCNQ1;KCNQ3;KCNG2;KCNG1;KCNA1
voltage-gated potassium channel activity	KCNH1A;KCNAB1A;KCNG4A;KCNC2;KCNC1A;KCNV2B;CNGA5;KCNAB2B;KCNH2A

KCNA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA6.

HSP90AB1