KCNV2

  • Official Full Name

    potassium channel, subfamily V, member 2

  • Overview

    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a silent subunit, and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.

  • Synonyms

    KCNV2;potassium channel, subfamily V, member 2;potassium voltage-gated channel subfamily V member 2;Kv8.2;voltage-gated potassium channel subunit Kv8.2;RCD3B;KV11.1;MGC120515

    Involved Pathway

    KCNV2 involved in several pathways and played different roles in them. We selected most pathways KCNV2 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Potassium Channels KCNC1,KCNA10,KCNK18,KCNAB3,KCNQ2A,KCNQ3,KCNH5,KCNS3A,KCNK4,KCNK3A
    Voltage gated Potassium channels KCNA4,KCNAB2,KCNH2,KCNC4,KCNG3,KCNB2,KCNA6,KCNH8,KCNC1,KCNA10
    Neuronal System KCNK4,KCNQ2A,KCNJ14,KCNA2,KCNH6A,KCNS2,CHRNA2,KCNMB1,KCNN1A,STXBP1A

    Protein Function

    KCNV2 has several biochemical functions, for example, delayed rectifier potassium channel activity,ion channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNV2 itself. We selected most functions KCNV2 had, and list some proteins which have the same functions with KCNV2. You can find most of the proteins on our site.

    Function Related Protein
    voltage-gated potassium channel activity KCNC1A,CNGA5,KCNH6A,KCNQ3,HCN2,KCNH6,KCNH1B,KCNC3B,KCNA4,KCNH1A
    delayed rectifier potassium channel activity KCNC3B,KCNQ3,KCNF1,KCNG4A,KCNC3A,KCNH2,KCNC1,KCNC1A,KCNH1,KCNA5
    potassium channel activity KCNIP1,DDX1,KCNF1,KCNK4,KCNA6A,KCNK2B,KCNIP4,KCNQ4,AQP1,KCNK5
    ion channel activity CHRNA10A,P2RX5,TRPC4B,GRIA3A,TRPV5,TRPC7B,P2RX8,KCNH1A,DDX1,CACNA1C
    voltage-gated ion channel activity KCNJ1B,SCN1LAB,CLIC5B,KCNJ1A.1,CX35B,KCNF1A,KCNIP1,CLIC6,SCN4AA,CACNA1BA

    Interacting Protein

    KCNV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNV2.

    Resources

    References

    • VEH, RW; LICHTINGHAGEN, R; et al. IMMUNOHISTOCHEMICAL LOCALIZATION OF 5 MEMBERS OF THE KV1 CHANNEL SUBUNITS - CONTRASTING SUBCELLULAR LOCATIONS AND NEURON-SPECIFIC CO-LOCALIZATIONS IN RAT-BRAIN. EUROPEAN JOURNAL OF NEUROSCIENCE 7:2189-2205(1995).

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