kdm5d
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  • Official Full Name
  • lysine (K)-specific demethylase 5D
  • Background
  • This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • KDM5D; lysine (K)-specific demethylase 5D; HY, HYA, JARID1D, jumonji, AT rich interactive domain 1D , Jumonji, AT rich interactive domain 1D (RBP2 like) , SMCY, Smcy homolog, Y linked (mouse); lysine-specific demethylase 5D; KIAA0234; H-Y; Histocompatibility Y antigen; HY; HYA; JAD1D; Jumonji/ARID domain-containing protein 1D; protein SmcY; Smcy homolog, Y-linked; SMC homolog, Y chromosome; Smcy homolog, Y chromosome; histone demethylase JARID1D; selected mouse cDNA on Y, human homolog of; Jumonji, AT rich interactive domain 1D (RBP2-like); SMCY; JARID1D
Cat.#:KDM5D-8597MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KDM5D Protein
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Involved Pathway

KDM5D involved in several pathways and played different roles in them. We selected most pathways KDM5D participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
KDM1B; GATAD2AB; ACTL6A; CHD4; DNMT3A; ZZZ3; RBBP7; KANSL2; SUZ12; ELP4
Chromatin organization
MSL2B; GATAD2A; ANO9A; DMAP1; MBD3A; WDR77; SMARCD1; SMARCC1B; EP400; ATXN7L3
HDMs demethylate histones
KDM4C; KDM3A; PHF2; KDM2A; KDM5D; KDM6AL; ARID5B; KDM2AA; KDM5A; KDM4A

Protein Function

KDM5D has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5D itself. We selected most functions KDM5D had, and list some proteins which have the same functions with KDM5D. You can find most of the proteins on our site.
Function
Related Protein
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
Related Protein PHF2; KDM5BB; JMJD1C; KDM5D
Function C-19 gibberellin 2-beta-dioxygenase activity
Related Protein KDM5BB; PHF2; KDM5D; JMJD1C
Function C-20 gibberellin 2-beta-dioxygenase activity
Related Protein JMJD1C; KDM5D; PHF2; KDM5BB
Function DNA binding
Related Protein RABGEF1; SNAPC4; HIST1H4E; TIGD5; ZNF433; PRDM12; RFX5; ARID3B; PRIM2; IRX4B
Function DNA-N1-methyladenine dioxygenase activity
Related Protein ALKBH2; FTO; KDM5D; PHF2; ALKBH3; JMJD1C; KDM5BB
Function dioxygenase activity
Related Protein KDM6A; PHF2; ALOX5B.2; KDM3A; ASPHD1; PTGS2; KDM4C; PLOD1A; KDM4D; OGFOD2
Function histone demethylase activity (H3-K4 specific)
Related Protein KDM5C; KDM5B; KDM1A; KDM5D; C14orf169
Function hypophosphite dioxygenase activity
Related Protein KDM5BB; KDM5D; PHF2; JMJD1C
Function metal ion binding
Related Protein MT1HL1; ZNF124; HDAC5; ZNF562; ENPP5; ZNF766; ZNF16; GNA12; NEK5; AGFG1B
Function oxidoreductase activity
Related Protein KDM5BB; DHRS7CA; ALDH3A2A; GSTO2; HSDL2; DAO.1; DHRS11B; DCT; ALDH2.1; ETFA
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Related Protein P4HTM; EGLN3; KDM5C; TYW5; PHF8; ALKBH5; HIF1AN; JHDM1D; KDM5D; C14orf169
Function procollagen-proline dioxygenase activity
Related Protein KDM5BB; KDM5D; JMJD1C; PHF2
Function sulfonate dioxygenase activity
Related Protein JMJD1C; KDM5BB; KDM5D; PHF2
Function zinc ion binding
Related Protein GFI1AB; RNF138; RPS29; LMX1BB; TRIM43B; ADAMTS1; IGHMBP2; CXXC1B; S100A6; KDM2BA

KDM5D Related Articles

Kawase, T; Ord, ND; et al. Frequency and Intensity of Antibody Responses to Antigens Encoded by KDM5D (SMCY) and Other H-Y Genes After Allogeneic Hematopoietic Cell Transplantation. BLOOD 118:1721-1721(2011).