klf11
Share
  • Official Full Name
  • Kruppel-like factor 11
  • Background
  • The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms
  • KLF11; Kruppel-like factor 11; TGFB inducible early growth response 2 , TIEG2; Krueppel-like factor 11; MODY7; Tieg3; TIEG-2; TGFB-inducible early growth response protein 2; transforming growth factor-beta-inducible early growth response protein 2; FKLF
Cat.#:KLF11-087HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLF11 Protein, GST-HIS-tagged
+Inquiry
Cat.#:KLF11-8675MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KLF11 Protein
+Inquiry
Cat.#:KLF11-1559CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KLF11
+Inquiry
Cat.#:KLF11-4932HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KLF11 293 Cell Lysate
+Inquiry

Involved Pathway

KLF11 involved in several pathways and played different roles in them. We selected most pathways KLF11 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
EGFR1 Signaling Pathway
JUND; ELF3; CRKL; PTPN12; PITPNA; CEACAM1; EEF1A1; PLSCR1; CEBPB; EPPK1

Protein Function

KLF11 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF11 itself. We selected most functions KLF11 had, and list some proteins which have the same functions with KLF11. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein SOX9A; BHLHE40; JUNBB; FOXR2; GATA6; SP2; SIM1; FOXA; SOX9B; FOXG1D
Function metal ion binding
Related Protein WT1B; LIG1; IKBKG; ZNF559-ZNF177; EYA1; RAF1B; PFKP; ZBTB8B; ZNF124; TNFRSF11A
Function protein binding
Related Protein THOC4; PLEKHF2; DCTN5; DUT; AKAP7; CSF1; MYL12B; E2F6; CNNM3; RAB37
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF550; EF1; HOXC4A; NKX2-1; HOXA4A; DLX6; NFIA; NR2F1B; ZNF227; ATF2
Function transcription regulatory region DNA binding
Related Protein IKZF2; JUN; KLF11; PPARG; ARID4A; YAP1; GABPA; GATA6; SP1; TFAP2A

Interacting Protein

KLF11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF11 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF11.
TXNDC9; APPBP2; g3h0f0_crigr; CLU; HTT; ATXN1; YWHAZ; q81ye8_bacan; APH1A; TIMM13

KLF11 Related Articles

Grisaru-Granovsky, S; Salah, Z; et al. Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: a pilot study querying an association beyond coagulation. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 185:13-18(2015).
Loft, A; Forss, I; et al. Browning of human adipocytes requires KLF11 and reprogramming of PPAR gamma superenhancers. GENES & DEVELOPMENT 29:7-22(2015).