lass4
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  • Official Full Name
  • ceramide synthase 4
  • Background
  • Ceramide synthase 4 (CerS4) is an enzyme that in humans is encoded by the CERS4 gene and is one of the least studied of the ceramide synthases.
  • Synonyms
  • LAG1 homolog, ceramide synthase 4; CerS4; FLJ12089; Trh1; LAG1 longevity assurance homolog 4 (S. cerevisiae); LAG1 longevity assurance homolog 4; LASS4; ceramide synthase 4
Cat.#:LASS4-8966MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LASS4 Protein
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Involved Pathway

LASS4 involved in several pathways and played different roles in them. We selected most pathways LASS4 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LASS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid metabolism
UGCG; ASAH1A; FA2H; SPTLC2A; UGT8; SMPD2A; SPHK2; GDF1; DEGS2; NEU3.2
Metabolic pathways
G6PD; TPH2; DHRS4L2; HYAL2; DCXR; MTMR7; UGP2A; DAD1; POLR2J3; ATP5F1
Sphingolipid signaling pathway
PTEN; PRKCB; PLCB1; OPRD1; ROCK2; KRAS; BAX; PPP2R2A; PIK3CG; PLCB2

Protein Function

LASS4 has several biochemical functions, for example, DNA binding, sphingosine N-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LASS4 itself. We selected most functions LASS4 had, and list some proteins which have the same functions with LASS4. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ASXL2; HOXC3A; TAF4B; RAD51L1; APP; VOX; TBR1B; ANO9A; TFDP1; BARX2
Function sphingosine N-acyltransferase activity
Related Protein CERS3B; CERS4; FAM57B; LASS1; CERS2; LASS4; LASS5; LASS2; CERS5; CERS2A

LASS4 Related Articles

Ebel, P; Imgrund, S; et al. Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. BIOCHEMICAL JOURNAL 461:147-158(2014).
Haller, JF; Cavallaro, P; et al. Endogenous beta-glucocerebrosidase activity in Abca12(-/-) epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. JOURNAL OF LIPID RESEARCH 55:493-503(2014).