lig4
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  • Official Full Name
  • ligase IV, DNA, ATP-dependent
  • Background
  • The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LIG4; ligase IV, DNA, ATP-dependent; DNA ligase 4; sealase; DNA joinase; DNA ligase IV; DNA repair enzyme; polynucleotide ligase; polydeoxyribonucleotide synthase [ATP] 4;
Cat.#:LIG4-508HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LIG4 protein, GST-tagged
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Cat.#:LIG4-9098MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LIG4 Protein
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Cat.#:LIG4-2513CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LIG4
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Cat.#:LIG4-5960ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LIG4
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Cat.#:LIG4-4745HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LIG4 293 Cell Lysate
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Cat.#:LIG4-4746HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LIG4 293 Cell Lysate
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Involved Pathway

LIG4 involved in several pathways and played different roles in them. We selected most pathways LIG4 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIG4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Non-homologous end-joining
POLL; XRCC6; MRE11A; XRCC4; XRCC5; NHEJ1; POLM; PRKDC; LIG4; FEN1

Protein Function

LIG4 has several biochemical functions, for example, ATP binding, DNA binding, DNA ligase (ATP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIG4 itself. We selected most functions LIG4 had, and list some proteins which have the same functions with LIG4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TTLL9; MCM5; MAPK1; NME3; CLCN6; IPMK; DDX51; ATAD5B; RAD54B; ACTR2A
Function DNA binding
Related Protein MAPK1; NR1D2A; NR1D4A; ILF3; ZFP354C; PLSCR1; SOX8; ATOH8; POU2F1B; PALB2
Function DNA ligase (ATP) activity
Related Protein LIG3; LIG1; LIG4
Function DNA ligase activity
Related Protein LIG1; LIG4; LIG3
Function ligase activity
Related Protein TRIM58; HERC3; TRIM31; HECTD3; RAD18; RNF213; CBLB; MYLIPB; TRIM71; RFFL
Function metal ion binding
Related Protein CYP7A1A; PLEKHF2; VEZF1B; PEG3; ZNF613; CYP2J6; GFI1AB; GALNT14; MPO; ZBTB43
Function protein C-terminus binding
Related Protein PEX5; BLOC1S2A; SLC4A1; VPS36; TRIM3; ERCC3; COIL; PEX12; XRCC5; TNNI3K
Function protein binding
Related Protein MTAP; DNTT; TMUB2; RAB17; CBX6; FAM9A; SPRED2; PSMB3; RNH1; PRMT3

Interacting Protein

LIG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIG4.
XRCC4; APLF; NHEJ1; PNKP; TSFM; GZMK; ZSCAN18; PHF10; XRCC6

LIG4 Related Articles

Cordoba-Canero, D; Roldan-Arjona, T; et al. Arabidopsis ARP endonuclease functions in a branched base excision DNA repair pathway completed by LIG1. PLANT JOURNAL 68:693-702(2011).
Paddock, MN; Bauman, AT; et al. Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair. DNA REPAIR 10:338-343(2011).