|Background||Lysostaphin is a Staphylococcus simulans metalloendopeptidase. It can function as an antimicrobial against Staphylococcus aureus. Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycin bridges in the cell wall of Staphylococci. Lysotaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. S. aureus cell walls contain high proportions of pentaglycin, making lysostaphin a highly effective agent against both actively growing and quiescent bacteria. Staphylococcal infections of both Staphylococcus aureus and Staphylococcus epidermidis continue to be a major issue in clinical settings, particularly those with implantable devices. Staphylococci cause a significant percentage of device infections, and like many other pathogens, rather than living as free planktonic cells within the host they have the ability to form a multilayered community of sessile bacteria cells known as a biofilm on implantable devices. Once a "Staphylococcal" biofilm has formed on an implanted medical device, it is difficult to disrupt due to its antibiotic resistance and protection against bacterial action.|
|Synonyms||Lysostaphin; Staphylococcus simulans metalloendopeptidase; 27 KDa; glycylglycine endopeptidase; antibacterial enzyme; Glycyl-glycine endopeptidase; Iss|
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Lysostaphin involved in several pathways and played different roles in them. We selected most pathways Lysostaphin participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Lysostaphin were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Lysostaphin has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Lysostaphin itself. We selected most functions Lysostaphin had, and list some proteins which have the same functions with Lysostaphin. You can find most of the proteins on our site.
Lysostaphin has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lysostaphin here. Most of them are supplied by our site. Hope this information will be useful for your research of Lysostaphin.