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Lysostaphin

  • Overview

    Lysostaphin is a Staphylococcus simulans metalloendopeptidase. It can function as an antimicrobial against Staphylococcus aureus. Lysostaphin is a 27 KDa glycylglycine endopeptidase, an antibacterial enzyme which is capable of cleaving the crosslinking pentaglycin bridges in the cell wall of Staphylococci. Lysotaphin was first isolated from a culture of Staphylococcus simulans by Schindler and Schuhardt in 1964. S. aureus cell walls contain high proportions of pentaglycin, making lysostaphin a highly effective agent against both actively growing and quiescent bacteria. Staphylococcal infections of both Staphylococcus aureus and Staphylococcus epidermidis continue to be a major issue in clinical settings, particularly those with implantable devices. Staphylococci cause a significant percentage of device infections, and like many other pathogens, rather than living as free planktonic cells within the host they have the ability to form a multilayered community of sessile bacteria cells known as a biofilm on implantable devices. Once a "Staphylococcal" biofilm has formed on an implanted medical device, it is difficult to disrupt due to its antibiotic resistance and protection against bacterial action.
  • Synonyms

    Lysostaphin; Staphylococcus simulans metalloendopeptidase; 27 KDa; glycylglycine endopeptidase; antibacterial enzyme; Glycyl-glycine endopeptidase; Iss;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Staphylococcus staphylolyticus Lysostaphin-91S Active Native Staphylococcus staphylolyticus Lysostaphin Staphylococcus Staphylolyticus N/A
Lysostaphin-90 Recombinant Lysostaphin E.coli N/A

Lysostaphin involved in several pathways and played different roles in them. We selected most pathways Lysostaphin participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Lysostaphin were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Lysostaphin has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Lysostaphin itself. We selected most functions Lysostaphin had, and list some proteins which have the same functions with Lysostaphin. You can find most of the proteins on our site.

Function Related Protein

Lysostaphin has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lysostaphin here. Most of them are supplied by our site. Hope this information will be useful for your research of Lysostaphin.

  • Q&As
  • Reviews

Q&As (7)

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Against which bacteria is lysostaphin most effective? 02/13/2022

It is most effective against Staphylococcus aureus, including MRSA strains.

How can lysostaphin be administered for therapeutic purposes? 01/27/2021

Lysostaphin can be administered topically, intravenously, or via aerosol for respiratory infections.

How can lysostaphin be used in clinical settings? 01/07/2020

Lysostaphin can be used to treat bacterial infections, especially those caused by staphylococci.

What is the primary mechanism of action of lysostaphin? 09/09/2019

Lysostaphin cleaves the cell wall of bacteria, leading to cell lysis.

What are the potential benefits of using lysostaphin over traditional antibiotics? 01/23/2019

It offers a targeted approach, potentially reducing the risk of antibiotic resistance.

What are the potential side effects or limitations of using lysostaphin? 01/02/2019

Potential limitations include allergic reactions and development of resistance.

Are there any known resistance mechanisms against lysostaphin? 01/18/2018

Some staphylococcal strains have developed resistance through modifications in cell wall composition.

Customer Reviews (3)

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Reviews
12/11/2022

    Excellent quality and service.

    07/17/2022

      High purity, great for assays.

      01/30/2022

        Efficient, reliable, and pure.

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