MAP2K2 Protein, MAP2K2 mitogen-activated protein kinase kinase 2


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Official Full Name MAP2K2 mitogen-activated protein kinase kinase 2
Background MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
Synonyms MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
    Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His
    Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
    Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
    Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
    Human MAP2K2-968H Recombinant Human MAP2K2, GST tagged Insect Cell GST
    Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His
    Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
    Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His

    MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway ARRB2; Fasl; FAS; MAPK4; PPM1AB; PTPRR; Fgf15; ACVR1C; TGFB1A; MEF2CB
    ErbB signaling pathway AKT3A; SHC3; MAPK1; GSK3AA; RAF1B; PIK3R2; SOS1; SRC; GSK3B; NCK1
    Ras signaling pathway MAPK10; RASAL1; FGF3; NGF; ABL2; RAC2; GAB2; FGF13; PLCG1; IGF1R
    Rap signaling pathway GNAS; RASSF5; FGF10; MAGI1; PRKD2; F2RL3; VASP; PDGFB; FPR1; GRIN2B
    cGMP-PKG signaling pathway PPIF; PIK3CA; KCNMB4; ATP2A2; PLCB1; NPPB; ATP1A1; NPR2; INS; INS2
    cAMP signaling pathway PDE3B; NPR1; ARAP3; RAC1; CALM4; RAP1B; F2R; CREB3L3; GNAI1; CNGA4
    HIF- signaling pathway PIK3CA; HK1; PDHA2; PDHA1; GM5506; TFRC; PRKCG; SLC2A1; NOX3; ANGPT4
    FoxO signaling pathway CCNB2; SMAD3A; FOXO3A; GADD45AB; FOXO3B; PTENA; GADD45B; NRAS; PRMT1; INS2
    Sphingolipid signaling pathway ABCC1; GAB2; PLD1; PPP2R5C; PTEN; SPTLC2; PPP2R3A; LASS5; SMPD1; RAC3
    Phospholipase D signaling pathway GRM3; SHC2; AKT2; PLD1; PIK3CB; PLD2; AGTR1A; PTK2B; PTPN11; PLCB2
    PIK-Akt signaling pathway LAMB3; HSP90B1; LPAR5; Il6ra; PPP2CB; IL6R; FN1; ITGB1; FGFR3; KITLG
    Vascular smooth muscle contraction RHOAD; PRKACAA; PRKACB; CALML3; ROCK2B; MYLK3; CACNA1SB; ARHGEF11; RHOAC; CALM
    VEGF signaling pathway MAPK11; PLA2G4A; MAP2K2; PTGS2B; PRKCB; MAP2K2B; NRAS; PLA2G4D; HRAS; PRKCBA
    Signaling pathways regulating pluripotency of stem cells PCGF2; PIK3CG; FZD9; PIK3CA; FZD6; BMPR2; WNT9A; ACVR1; MAP2K1; FZD2
    Toll-like receptor signaling pathway CCL5; TRAF3; RIPK1L; MYD88; MAPK10; TLR4BA; AKT2; IKBKE; PIK3CG; PIK3R1
    Natural killer cell mediated cytotoxicity ULBP2; ICAM1; VAV3; IFNG; KRAS; PRKCA; KIR2DL1; H60a; TNFRSF10C; ITGAL
    T cell receptor signaling pathway PPP3R1; TNF; OXSR1A; DEF6A; EVLB; CD3E; CD3D; PAK2; CD8B; MAP3K7; RELA
    B cell receptor signaling pathway CARD11; PIK3R3; BLK; Cd79a, Cd79b; CD79B; LAT2; CDK4; ARPC4; NFKB1; PIK3AP1
    Fc epsilon RI signaling pathway TNF; PLA2G4C; MS4A2; MAP2K6; PRKCA; IL4; RAF1; MAPK10; FCER1A; MAP2K1
    Long-term potentiation PLCB2; PRKCA; PPP1CA; GRIN2A; CALML3; GRIA2; CAMK2G; RAP1A; NRAS; KRAS
    Neurotrophin signaling pathway SHC3; RIPK2; MAPK8; MAPK13; BAD; PSEN1; CALM2; NRAS; MAPKAPK2; TRAF6
    Long-term depression PLA2G4F; GNA13; HRAS; CRH; GNA11; PPP2CB; GNAI1; PRKCA; PPP2R1B; CRHR1
    Regulation of actin cytoskeleton SCINLA; PPP1CC; ITGB5; FGF3; ITGAE; ITGA5; RRAS; PPP1R12B; PAK6B; ROCK2B
    Insulin signaling pathway MAPK8B; INPPL1; FBP1B; ARAF; PPP1CAA; ACACA; INS2; PTPRFB; PDPK1; RPS6KB1
    GnRH signaling pathway MAPK14A; PRKCDA; CACNA1SB; GRB2B; CDC42L2; SRC; CAMK2B; MAPK12; RAF1A; MAP3K1
    Estrogen signaling pathway ITPR3; CALM4; CALM2; PRKACG; PIK3R2; HSPA1B; ESR1; KRAS; CALML3; HSPA2
    Melanogenesis CAMK2D1; CREB3L2; FZD7A; RAF1B; CAMK2A; CALM1B; GNA15.4; FZD6; EP300; WNT7B
    Prolactin signaling pathway INS2; SOCS7; MAP2K2; GRB2; SOCS1; SOCS3; CCND1; CSN2; CCND2; PIK3R3
    Thyroid hormone signaling pathway GSK3B; MAP2K2; PFKFB2; RCAN2; SLC9A1; ATP1A2; AKT1; SLCO1C1; PRKACG; TP53
    Oxytocin signaling pathway NFATC4; PIK3R5; TRPM2; PPP3CB; PLCB3; MEF2C; PLCB4; NFATC2; MAP2K1; PIK3CA
    Prion diseases HSPA5; IL1B; C1QA; C5; CCL5; LOC100033925; C8G; PRKACB; PRKACG; C7
    Hepatitis B Fasl; EGR3; AKT2; IFNA12; TLR4; TICAM2; APAF1; IL6; NFATC3; STAT4
    Influenza A IFNA13; LOC100033925; PIK3CG; IVNS1ABP; AGFG1; AKT2; TNFRSF10C; FASLG; HLA-DRB1; NXF2
    Pathways in cancer HDAC1; CASP9; VEGFB; GNGT1; RB1; MAPK9; XIAP; PDGFRB; Fzd4; FGF11
    Proteoglycans in cancer EZR; WNT7A; IL12B; PIK3R3; RRAS2; PPP1R12B; TIMP3; NUDT16L1; SLC9A1; PIK3CA
    MicroRNAs in cancer BMF; TP53; PRKCA; SERPINB5; MDM4; BMPR2; ABCB1; RPTOR; APC; ABL1
    Renal cell carcinoma HGF; PAK7; TGFB2; ARNT2; AKT2; PAK1; TGFB3; EP300; AHA-1; RAP1A
    Endometrial cancer AKT1; TRP53; CTNNA2; MAPK1; HRAS; PIK3CD; MAP2K2; CTNNA3; NRAS; MLH1
    Glioma CALM2; GRB2; PDGFRA; Pdgfa&Pdgfb; SHC1; PIK3CD; CAMK2A; IGF1; PTEN; HRAS
    Prostate cancer TCF7L2; CREB3L1; TGFA; RAF1; PIK3R1; NKX3; CREB3L2; AKT2; NKX3-1; PTEN
    Thyroid cancer NTRK1; TFG; NRAS; CCND1; MAP2K1; TCF7L2; MAPK3; TPM3; MAPK1; CCDC6
    Bladder cancer RB1; MAP2K2; MAPK1; TP53; UPK3A; DAPK3; MAPK3; ARAF; BRAF; MAP2K1
    Chronic myeloid leukemia PIK3CB; SOS1; SHC1; MAPK3; TP53; MECOM; NRAS; TGFBR2; BRAF; HRAS
    Acute myeloid leukemia PPARD; MAP2K2; SOS1; JUP; TCF7; RPS6KB2; PIK3CD; ZBTB16; STAT5A; RAF1
    Non-small cell lung cancer KRAS; PIK3CG; NRAS; RAF1; ALK; AKT2; CCND1; GRB2; TP53; RB1
    Central carbon metabolism in cancer PIK3R3; PDGFRA; PIK3CA; G6PD; ERBB2; SLC1A5; HKDC1; SLC2A1; SCO2; FGFR3
    Choline metabolism in cancer RPS6KB1; PLD2; WASF1; PLA2G4B; DGKG; LYPLA1; SLC44A2; MAPK3; RAC1; HIF1A

    MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ADK; FANCM; FGR; CDC34A; KIF20B; PANK4; EK1; RAF1A; ATP5A1; STK30
    MAP kinase kinase activity MAP2K2; LRRK2; MAPKAPK5; MAPK10; MAP2K2B; MAP2K7; MAP2K2A; MAP3K9; MAP3K20; MAP2K6
    PDZ domain binding TGFBR3; CXXC4; NLGN1; PTENA; LNX2; F11R; ARHGAP29; FZD7; CXADR; ATP2B1B
    metal ion binding PPP1CB; C2; ZFP146; S100T; ZBTB5; BTR30; HSCB; ZC3H8; NUDT12; ACAP2
    protein binding PEX14; CPSF3; TCF4; RFPL3; IRF4; CLK4; RAB11FIP5; GRAMD3; MRPL15; MTA3
    protein complex scaffold ISCU; TELO2; SMARCD1; AXIN1; CAV3; DLG1; MAGI1B; ARRB2; HOMER1; AKAP9
    protein serine/threonine kinase activator activity LTF; ALS2; CDK5R1; PARP16; IGF2; CAB39; STK4; FAM20A; CALM3; SPRY2
    protein serine/threonine kinase activity CSNK1G1; PRKACAA; PRKCQ; AAK1; TESK2; DAPK2; CDC7; LRRK2; AKT1; WNK1
    protein serine/threonine/tyrosine kinase activity AURKC; SGK1; AURKA; AURKB; CLK2; MAP2K2; DYRK1B; TESK2; DSTYK; RPS6KB1
    protein tyrosine kinase activity JAK2; FES; FGFR1; DYRK4; TNK1; FGFR4; MUSK; FYNA; FER; DYRK1B
    scaffold protein binding HOMER1; CHRNA7; TREM2; CHUK; IKBKB; CRIPT; CASP8; VIM; KCNH2; KRT5

    MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.


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