map2k2
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  • Official Full Name
  • MAP2K2 mitogen-activated protein kinase kinase 2
  • Background
  • MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
  • Synonyms
  • MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;
Cat.#:MAP2K2-253HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAP2K2 Protein, MYC/DDK-tagged
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Cat.#:MAP2K2-15860HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K2, His-tagged
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Cat.#:MAP2K2-29202THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAP2K2
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Cat.#:MAP2K2-301HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K2 protein, His/MBP-tagged
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Cat.#:MAP2K2-302HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K2 protein, His/MBP-tagged
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Cat.#:MAP2K2-968HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K2, GST tagged
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Cat.#:Map2k2-8085MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Map2k2 protein, His-tagged
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Cat.#:MAP2K2-3560RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP2K2 Protein
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Cat.#:MAP2K2-6940CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP2K2
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Cat.#:MAP2K2-350HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP2K2, GST-tagged, Active
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Cat.#:MAP2K2-1316HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged
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Cat.#:MAP2K2-613HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAP2K2 cell lysate
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Involved Pathway

MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RAP1B; NLK; FLNB; NFKB1; CACNA1SB; PPP3CCA; FGF10A; PRKCBB; FGF10; PPP3R2
ErbB signaling pathway
RAF1B; PRKCG; NRG1; PIK3CB; ERBB4; CBL; GSK3B; MYCB; PRKCBB; HRASA
Ras signaling pathway
MAP2K1; ETS1; HTR7; KITLG; PRKCA; RASA1; INSR; RELA; PDGFD; IKBKB
Rap signaling pathway
HRAS; MAP2K2; VEGFC; SRC; ACTG1; IGF1; ITGAL; PRKCI; FGF4; RASGRP3
cGMP-PKG signaling pathway
CREB3L1; IRS1; Adcy4; PPP3CC; MYLK4; PIK3CG; PLCB4; SLC8A1; TRPC6; MEF2C
cAMP signaling pathway
GLI1; SOX9; RELA; GRIN3B; ACOX3; HHIP; NPY1R; PRKACA; RRAS; SUCNR1
HIF- signaling pathway
TCEB1; TF; PRKCB; FLT1; INS2; INSR; PDK1; ERBB2; PFKFB3; PIK3R5
FoxO signaling pathway
MAPK10; KRAS; IGF1; GADD45AA; INSB; Fasl; SGK2; SGK2B; FOXO1B; RAF1
Sphingolipid signaling pathway
PRKCB; ASAH1; PPP2R3C; TRADD; MAPK12; S1PR2; FCER1A; AKT2; NFKB1; MS4A2
Phospholipase D signaling pathway
PPAP2A; PDGFB; AGPAT5; MAPK1; GRM7; FYN; SHC3; LPAR3; IL-8; GRM2
PIK-Akt signaling pathway
NGFR; FGFR2; IFNA21; PIK3R5; IFNA17; Kitl; GNB4; CCND2; FGF17; HSP90B1
Vascular smooth muscle contraction
MYL12.1; CALM; PLA2G6; PLA2G4F; PRKACA; RHOAB; RHOAC; PRKCG; GNA11A; PRKACAB
VEGF signaling pathway
NFATC2; MAPK11; CDC42L; NOS3; PRKCBB; CDC42L2; PPP3R2; VEGFAA; PLCG1; PIK3R3
Gap junction
GNAIA; HTR2CL1; ADRB3A; PLCB1; ADCY2B; DRD2A; Adcy4; TUBA3B; PRKACBB; TUBA3A
Signaling pathways regulating pluripotency of stem cells
PIK3CD; SMAD9; SMAD4; PAX6; OTX1; HNF1A; REST; PIK3R3; INHBC; WNT4
Toll-like receptor signaling pathway
TLR5B; AKT2L; IL12BA; TRAF3; IRF5; PIK3CD; IFNA8; TLR8; IL8L2; TLR7
Natural killer cell mediated cytotoxicity
IFNA14; IFNGR1; CD244; PAK1; PIK3R3; PIK3CD; CD247; IFNAR2; RAET1G; MAPK1
T cell receptor signaling pathway
OXSR1A; VAV3; PIK3CA; PPP3R1; FOS; PDCD1; NCK1; PIK3R5; PIK3CB; MAPK11
B cell receptor signaling pathway
PIK3R5; FCGR2B; NEDD9; STAP1; ITK; VAV2; CTNNB2; PLEKHA1; PDK2B; AKT1
Fc epsilon RI signaling pathway
PIK3R2; PIK3R3; MAPK10; PLA2G4A; MAPK9; MAPK12; BTK; PLCG1; PLA2G4D; MS4A2
Long-term potentiation
CAMK2D; PRKACA; PRKCA; PRKCB; PPP1CC; CALM4; GRIA2; RPS6KA1; BRAF; EP300
Neurotrophin signaling pathway
MAPK12; CAMK4; GAB1; NTRK2; RPS6KA2; CALML5; NGF; PSEN2; MAGED1; RPS6KA3
Long-term depression
GNAQ; PRKCB; PLA2G4D; PLCB3; GRIA3; CRHR1; GUCY1B3; GNAO1; PRKCA; PLA2G4C
Regulation of actin cytoskeleton
FGF8; PIK3R3A; ITGA6B; PDGFRB; FGF2; SOS1; SCINLB; ACTG1; ITGA6; VAV2
Insulin signaling pathway
PIK3R3B; FBP1B; RAF1B; PRKCZ; ELK1; PHKG2; CALM4; MKNK2; RAF1; LIPE
GnRH signaling pathway
MAP2K1; PTK2BB; GNAQ; GRB2; HBEGFA; GNA11B; CAMK2A; MAPK3; PRKCD; CALM1A
Estrogen signaling pathway
PIK3R1; SHC2; FKBP5; KCNJ9; ESR2; PIK3CA; HSPA1B; CREB3L1; SOS1; GNAI3
Melanogenesis
PLCB2; PRKACBA; KIT; GNAI3; TYRP1; WNT2; Fzd4; WNT11R; GNA15.1; FZD7
Prolactin signaling pathway
TH; NRAS; KRAS; PIK3R5; NEK3; STAT1; SRC; PIK3CA; LHCGR; MAPK11
Thyroid hormone signaling pathway
PIK3CG; PLCZ1; ATP1B3; MTOR; HIF1A; MAPK1; ATP1B4; NOTCH2; KRAS; NCOR1
Oxytocin signaling pathway
GNAI2; PTGS2; RYR3; MEF2C; RAF1; PPP3R1; MAPK7; CAMK2G; NFATC1; GNAQ
Prion diseases
MAP2K2; IL1B; MAPK3; MAPK1; C5; C7; C1QB; BAX; CCL5; Hc
Hepatitis B
SRC; PIK3CG; NFATC4; TLR2; IFN-a; IRF7; IFIH1; NFKB1; PCNA; ATP6AP1
Influenza A
OAS3; IFNA13; CASP9; MAP2K7; IL-8; MAP2K1; MAPK13; FAS; IFNA6; KPNA1
Pathways in cancer
ITGA6; GNG12; NFKB2; TCEB1; STAT5A; RASGRP3; TPM3; FZD5; RALGDS; RAF1
Proteoglycans in cancer
Ctsl; MAPK3; MRAS; MET; ITPR3; WNT7B; PTPN11; RPS6; WNT2; SLC9A1
MicroRNAs in cancer
VEGFA; NOTCH4; STMN1; ZEB2; TRIM71; PLAU; GLS2; DNMT3B; SHC4; MMP16
Renal cell carcinoma
HIF1A; MAP2K2; RAP1A; MAPK3; EGLN2; TCEB2; PIK3CG; ARNT; TGFB1; SLC2A1
Endometrial cancer
PIK3R2; PDPK1; TCF7L2; ERBB2; MAPK3; AXIN2; PIK3R3; BAD; HRAS; MAP2K1
Glioma
CALM1; SHC2; AKT1; MAPK1; KRAS; PIK3CD; PTEN; CAMK2G; PIK3R5; CALML5
Prostate cancer
NKX3; SPINK1; MAP2K1; HSP90AB1; PIK3CB; PIK3R5; PTEN; HRAS; RB1; CASP9
Thyroid cancer
TPR; KRAS; CCND1; PAX8; HRAS; TFG; NTRK1; RXRB; NRAS; PPARG
Melanoma
PIK3R2; PIK3R3; PDGFB; Pdgfa&Pdgfb; FGF22; BRAF; Fgf15; AKT2; FGF18; FGF20
Bladder cancer
MDM2; CCND1; DAPK2; MAP2K1; CDK4; TYMP; RAF1; HRAS; FGFR3; CXCL8
Chronic myeloid leukemia
MAPK1; CRK; PIK3R1; PIK3CD; GRB2; PIK3CB; ARAF; KRAS; BRAF; BAD
Acute myeloid leukemia
KRAS; MYC; TCF7L2; PIK3CA; RUNX1; BAD; CEBPA; LEF1; AKT3; PML
Non-small cell lung cancer
PIK3CA; PLCG2; BRAF; PIK3CG; AKT2; HRAS; ERBB2; CASP9; PIK3R2; TGFA
Central carbon metabolism in cancer
TRP53; PKM2; PDGFRB; KRAS; PDHB; NTRK1; PIK3R5; AKT2; PIK3R2; PIK3R1
Choline metabolism in cancer
SP1; TSC2; MAPK8; NRAS; WASL; WASF3; PCYT1A; DGKD; PLD1; AKT1

Protein Function

MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SEPHS2; P2RY2; OXSR1; ERBB4; CTPS1A; NAIP7; TSSK1; PTK2B; NLRP3; MAP4K6
Function MAP kinase kinase activity
Related Protein MAP3K20; ALPK2; MAP2K2; MAP2K2A; MAP3K14; LRRK2; MAP2K6; MAPK14; MAP3K9; MAP2K2B
Function PDZ domain binding
Related Protein DOCK4; Apba1; CXXC4; FZD3; NLGN1; TBC1D10A; SNTB1; DLC; LPAR1; LPAR2
Function metal ion binding
Related Protein S100A10B; ZNF583; NPTX2; MORC1; DAK; VAV3; GNPTAB; PRUNE2; Car8; FREM1
Function protein binding
Related Protein ALX1; SPATA22; PRUNE; ROPN1; RBM10; FAM110A; ACAN; NDOR1; TBC1D23; POLA1
Function protein complex scaffold
Related Protein WWC3; MAGI1; SLC9A1; SEPT2; CNOT1; WWC1; CAV3; AXIN1; AKAP9; SLC9A3R1
Function protein serine/threonine kinase activator activity
Related Protein ALS2; PARP16; MAP2K1; IGF2; CAB39; STK4; MAP2K2; CDK5R1; CALM3; CALM2
Function protein serine/threonine kinase activity
Related Protein PKZ; MAP2K4; PDIK1L; BMPR1A; MAP4K4; SIK2; SBK3; MAP4K1; TLK1B; CAMK1GB
Function protein serine/threonine/tyrosine kinase activity
Related Protein CLK3; PRKACA; CLK2; DYRK1AA; AURKC; TTK; RPS6KA1; TNK2; DSTYK; CLK4
Function protein tyrosine kinase activity
Related Protein BTK; KDRL; ERBB2; BAZ1B; SYK; EPHA2A; TTN; ROS1; DYRK3; WEE1
Function scaffold protein binding
Related Protein GRIN2A; NLGN3; LRP4; NOS1; PDE4D; MDM2; DLG4; VIM; DSP; NLGN4Y

Interacting Protein

MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.
ARAF; RAF1; BRAF; CCNDBP1; COPS5