Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged

Cat.No. : Map2k2-3921M
Product Overview : Purified recombinant protein of mouse full-length mitogen-activated protein kinase kinase 2 (Map2k2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 44.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Map2k2 mitogen-activated protein kinase kinase 2 [ Mus musculus (house mouse) ]
Official Symbol : Map2k2
Synonyms : MAP2K2; mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; ERK activator kinase 2; mitogen activated protein kinase kinase 2; protein kinase, mitogen activated, kinase 2, p45; MK2; MEK2; Prkmk2; AA589381
Gene ID : 26396
mRNA Refseq : NM_023138
Protein Refseq : NP_075627
UniProt ID : Q63932

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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