mapk13
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  • Official Full Name
  • mitogen-activated protein kinase 13
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.
  • Synonyms
  • MAPK13; mitogen-activated protein kinase 13; PRKM13; p38delta; SAPK4; MAPK 13; MAP kinase 13; MAP kinase p38 delta; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MGC99536
Cat.#:MAPK13-383HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPK13 Protein, MYC/DDK-tagged
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Cat.#:MAPK13-31379THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK13, His-tagged
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Cat.#:MAPK13-31380THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK13
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Cat.#:MAPK13-31HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK13, His-tagged
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Cat.#:MAPK13-357HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAPK13 Protein, GST-tagged, Activated
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Cat.#:MAPK13-374HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK13, GST-tagged, Active
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Cat.#:MAPK13-48HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK13, GST-tagged
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Cat.#:MAPK13-737HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 13
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Cat.#:MAPK13-945HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK13, GST tagged
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Cat.#:MAPK13-1285HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 13, His-tagged
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Cat.#:MAPK13-574HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK13 cell lysate
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Involved Pathway

MAPK13 involved in several pathways and played different roles in them. We selected most pathways MAPK13 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
NRAS; GADD45B; AKT2L; GADD45BA; MAPK1; ARR3A; PRKACA; TGFBR2; ARRB2A; FGF12A
Rap signaling pathway
CALM3; MAP2K2; GNAI1; VEGFB; MAP2K1; ANGPT4; MAPK12; FGF7; FGFR2; PRKCZ
FoxO signaling pathway
GADD45AB; CCND1; PRKAG3B; SOD2; MAPK10; PRMT1; EP300; AKT2; KLF2; FBXO32
Sphingolipid signaling pathway
PLD1; PPP2R1A; RAC2; MS4A2; SMPD2; SGMS1; ASAH1; FCER1A; PPP2R5A; PLCB2
Adrenergic signaling in cardiomyocytes
CACNG8; CACNA2D2; ATP1A3B; CREB3L3A; CACNA2D3; CACNG7A; CALM3; CAMK2A; CAMK2B1; CREB3L1
VEGF signaling pathway
PRKCA; PIK3R3A; RAC3; MAPK13; HRASB; HSPB1; PTK2; HRAS; MAPK12B; MAP2K1
Osteoclast differentiation
PPP3CB; LILRA4; AKT1; FCGR3; TNFRSF1A; LILRA5; FOSL1; CYBB; NFKB1; LCP2
Signaling pathways regulating pluripotency of stem cells
IGF1R; BMPR1A; INHBA; INHBC; ZIC3; ACVR1; HRAS; POU5F1; WNT9B; ZFHX3
Platelet activation
ITGB1; MYL12A; GP1BA; APBB1IP; COL27A1; ARHGEF12; PRKCI; ROCK2; MYLK3; PIK3CD
Toll-like receptor signaling pathway
TMED7-TICAM2; NFKBIA; IFNA6; TBK1; CCL4L2; TLR4BB; IRF3; CCL3L3; CXCL11; MAPK3
NOD-like receptor signaling pathway
IL8L2; IL-8; CASP8; MAPK11; CCL2; MAPK12B; MAPK10; BIRC3; MAPK12A; CXCL2
RIG-I-like receptor signaling pathway
DDX3; TRADD; PL10; TMEM173; TNF; ISG15; CXCL8B.3; IKBKE; ATG12; NFKBIA
T cell receptor signaling pathway
LCP2; ZAP70; PIK3R2; RHOA; PTPN6; NCK2; MAPK12; PIK3CD; OXSR1A; PIK3CA
Fc epsilon RI signaling pathway
VAV3; SYK; INPP5D; PIK3R3; RAF1; GRB2; PIK3R2; HRAS; PIK3R1; MS4A2
TNF signaling pathway
PIK3R3; FADD; DNM1L; MAP2K4; PTGS2; RPS6KA4; TRAF2; CCL2; Ccl12; MAP3K7IP3
Leukocyte transendothelial migration
CLDN10; CLDN11; PTPN11; MAPK13; MLLT4; EZR; MSN; CD99; RASSF5; PTK2B
Neurotrophin signaling pathway
GAB1; SH2B1; BAX; SHC4; IKBKB; CAMK2A; RELA; SH2B2; RPS6KA5; NTF3
Retrograde endocannabinoid signaling
PRKACB; GNG11; GABRR3; GNAQ; PRKCB; GRIA4; GNG10; PTGS2; DAGLB; GNG7
Dopaminergic synapse
COMT; CALM3; GNG10; CALY; ARRB2; PPP2R5D; CREB3L3; GNG11; GNAL; PPP3CC
Inflammatory mediator regulation of TRP channels
NTRK1; MAPK11; PLA2G6; CAMK2G; IL1R1; PRKCA; PPP1CC; TRPV1; PRKCE; PRKCD
GnRH signaling pathway
GNA15.4; MAPK9; LHBETA1; PLA2G4AA; PLA2G4F; CALM2B; GNRHR2; RAF1A; PRKCDA; EGFRA
Progesterone-mediated oocyte maturation
MAPK12; MAD2L2; RAF1; MAPK12B; HSP90AB1; GNAI3; RPS6KA3B; GNAI2; INSB; MAPK11
Prolactin signaling pathway
GALT; PIK3R2; ESR2; CCND1; RELA; PRP2; MAPK12; ESR1; PIK3CB; MAPK3
Amyotrophic lateral sclerosis (ALS)
CASP9; CCS; GRIN1; GRIN2B; RAC1; MAP2K3; PPP3R2; BID; GRIN2C; GRIN2D
Epithelial cell signaling in Helicobacter pylori infection
NFKB1; CXCR1; LYN; ATP6V1D; NOD1; ATP6V0E1; GIT1; MAPK8; ATP6V0A1; ATP6V1H
Shigellosis
ACTB; NFKB1; FBXW11; WASF1; U2AF1L4; CD44; PFN3; PFN4; ROCK1; WASL
Salmonella infection
CASPA; WASLA; NFKB1; WAS; CXCL2; TLR4BA; NOS2B; CXCL8B.3; NOS2A; CCL3L1
Pertussis
Itgam&Itgb2; CASP1; GNAI1; MAPK13; C1QB; C3; CXCL6; IRF8; IL1A; CALM2
Leishmaniasis
TLR4; IFNGR2; HLA-DMB; ITGAM; MAPK12; IRAK4; H2-AA; IFNGR1; MAPK1; TGFB1
Chagas disease (American trypanosomiasis)
PPP2R2B; PPP2R2A; FASLG; PPP2CA; TGFBR2; PIK3R5; CFLAR; GNAI3; MAP2K4; PIK3CA
Toxoplasmosis
IKBKG; IFNGR1; SOCS1; AKT2; LAMA3; MAPK1; MAPK13; IRGM1; IKBKB; MAPK3
Tuberculosis
CLEC7A; ATP6V0A4; cgr2b; PPP3R2; PLK3; BAX; IL18; NFYB; HSPA9; ATP6V0D1
Hepatitis C
OAS3; RELA; PPARA; IFNA7; PIK3R3; CLDN7; SOCS3; RIPK1; IFNA12; MAPK3
Influenza A
NLRX1; RNASEL; IFNA7; HLA-DRB5; MAPK11; IFNA10; RELA; HLA-DMA; RAF1; HLA-DQA1
Epstein-Barr virus infection
CCNA1; PSMD12; PSMD8; HLA-DRB5; PSMC5; RAN; HLA-F; GSK3B; POLR2L; TRAF5
Proteoglycans in cancer
PTK2; GRB2; ITGB1; CD44; PTPN11; MAPK12; TRP53; TIMP3; WNT3; FZD3

Protein Function

MAPK13 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK13 itself. We selected most functions MAPK13 had, and list some proteins which have the same functions with MAPK13. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NOD1; PNCK; TGFBR1; CHD4; MAP3K13; EPHA4B; CARNS1; EPHA4A; DNAH14; DDX51
Function MAP kinase activity
Related Protein MAPK8B; NLK1; MAPK8A; MAPK12B; MAPK7; NLK2; MAPK14A; MAPK14B; MAPK11; MAPK3
Function protein binding
Related Protein ICA1L; GIT2; MTERF; SPEF2; TOLLIP; C19orf46; TNK1; NUCB1; TTC19; TRIP10
Function protein serine/threonine kinase activity
Related Protein MOS; STK25; MAPKAPK5; DYRK4; MAPK13; STK31; MAPK4; STK19; ROCK2B; NIM1K

Interacting Protein

MAPK13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK13.
PRKD1; FPR1; saicar; PKM; ATF2; MAPKAPK3; Pkd1; MAP3K4; GPX4; SMAD4; ANKLE2; AKIP1; pi3p