mapk13
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  • Official Full Name
  • mitogen-activated protein kinase 13
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.
  • Synonyms
  • MAPK13; mitogen-activated protein kinase 13; PRKM13; p38delta; SAPK4; MAPK 13; MAP kinase 13; MAP kinase p38 delta; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MGC99536
Cat.#:MAPK13-383HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAPK13 Protein, MYC/DDK-tagged
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Cat.#:MAPK13-31379THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK13, His-tagged
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Cat.#:MAPK13-31380THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK13
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Cat.#:MAPK13-31HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK13, His-tagged
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Cat.#:MAPK13-357HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MAPK13 Protein, GST-tagged, Activated
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Cat.#:MAPK13-374HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK13, GST-tagged, Active
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Cat.#:MAPK13-48HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK13, GST-tagged
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Cat.#:MAPK13-737HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 13
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Cat.#:MAPK13-945HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK13, GST tagged
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Cat.#:MAPK13-1285HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 13, His-tagged
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Cat.#:MAPK13-574HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK13 cell lysate
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Involved Pathway

MAPK13 involved in several pathways and played different roles in them. We selected most pathways MAPK13 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TGFBR1; MAP3K4; CD14; PLA2G4C; FGF14; FGF21; ARRB2; MAP3K6; PAK2B; PRKACG
Rap signaling pathway
GNAS; RAF1; HRAS; FGF13; FIGF; MRAS; CALML3; RAP1GAP; INS2; RRAS
FoxO signaling pathway
CCND2; SOS1; G6PCA.1; MAPK1; PLK4; CCNB2; FBXO25; AKT2L; TGFB2; SOD2
Sphingolipid signaling pathway
PIK3CD; PIK3R5; LASS2; ROCK1; ASAH1; ASAH2; PLCB2; PIK3R3; SGPL1; AKT1
Adrenergic signaling in cardiomyocytes
AGTR2; PPP2R5E; SLC9A1; MAPK12; PRKACB; CREB5; PPP1CC; CACNA1SB; ADCY1; NETO2
VEGF signaling pathway
PPP3CB; AKT3A; PLA2G4F; PPP3CCB; PLA2G4D; PIK3R3; RAC3A; RAC3; MAPKAPK2A; RAC3B
Osteoclast differentiation
IL1B; FCGR1A; AKT2; NFATC1; PPP3CA; PIK3R3; MAPK11; PPP3R2; MAPK8; MAPK13
Signaling pathways regulating pluripotency of stem cells
ACVR1B; ID3; MAPK13; WNT10B; ID1; ESRRB; KLF4; WNT11; OTX1; MAPK1
Platelet activation
MAPK13; MAPK3; PRKCI; SYK; ARHGEF12; ACTB; PLA2G4C; PRKG2; VWF; RHOA
Toll-like receptor signaling pathway
TLR1LB; CRFB2; TLR4BB; FOS; TLR1LA; IFNA21; IFNA5; IFNPHI1; TLR5; MAP2K7
NOD-like receptor signaling pathway
HSP90AA1.2; IL6; NLRP1; CCL5; HSP90AA1.1; MAPK14A; MAPK8B; MAPK8A; NFKBIAB; CARD8
RIG-I-like receptor signaling pathway
IL8L1; IFNW1; SIKE1; IFNA17; RIPK1L; PIN1; MAPK8; IL12BA; CASP8; IKBKE
T cell receptor signaling pathway
CD8B1; NFATC3; MAP2K2; IL4; GRAPA; MAP3K14; SOS1; NFATC1; ICOS; MAPK3
Fc epsilon RI signaling pathway
SYK; INPP5D; PLA2G4A; PDPK1; MAP2K3; RAC1; MS4A2; PLA2G4C; MAP2K4; SOS1
TNF signaling pathway
BIRC3; CCL5; CXCL5; Ccl12; TRAF1; PIK3CD; MMP14; FOS; CXCL3; CX3CL1
Leukocyte transendothelial migration
PLCG1; PIK3R5; ACTN2; PRKCA; MYL12A; CTNNA3; VAV3; CLDN22; CLDN4; MYL5
Neurotrophin signaling pathway
PLCG1; MAPK9; PSEN2; YWHAE; SHC4; TP53; NFKBIA; PIK3CD; RPS6KA3; SH2B3
Retrograde endocannabinoid signaling
GABRG2; GNB1; ITPR1; MAPK12; GRM1; GABRA6; GRM5; GNG7; MAPK8; MAPK11
Dopaminergic synapse
CAMK2B; MAPK10; GNG5; KCNJ6; GNG12; PPP2R2A; AKT2; KIF5C; CAMK2G; PPP2CB
Inflammatory mediator regulation of TRP channels
MAPK13; PIK3CG; IL1R1; MAPK12; ACCN3; PLA2G4D; HTR2C; MAPK10; PRKCD; PLCB4
GnRH signaling pathway
HRASA; MAP3K3; CALM2B; MAP2K3; GNRHR4; GNA15.4; PRKCDA; PRKACB; HBEGFA; MAP2K1
Progesterone-mediated oocyte maturation
ADCY2B; MAD2L1; ANAPC2; CDC23; AKT3A; PIK3CG; MAPK14A; MAPK8B; RAF1B; PIK3R3B
Prolactin signaling pathway
FOS; SLC2A2; PIK3R3; FOXO3; CCND2; TNFSF11; SHC1; ESR1; SOCS2; STAT5A
Amyotrophic lateral sclerosis (ALS)
CASP9; CYCS; BCL2L1; NEFH; PPP3CB; CAT; MAPK11; BID; APAF1; GRIA1
Epithelial cell signaling in Helicobacter pylori infection
CCL5; CDC42; CXCL1; ATP6V0E1; ATP6V0A4; TJP1; ATP6V1E2; ATP6AP1; ATP6V1B1; ATP6V1B2
Shigellosis
ROCK1; ELMO1; PFN1; PFN4; IL-8; MAPK12; RAC1; NFKB1; DIAPH1; ROCK2
Salmonella infection
CCL4L1; IL18; ARPC5LA; PKN2; PKN1; LBP; KLC1A; PFN3; RAB7; TLR5
Pertussis
IL-8; MAPK3; Il23a; Il12b; CD14; GM5077; Itgam&Itgb2; RHOA; AMCF-II; MAPK12; GNAI3
Leishmaniasis
IL12A; IRAK4; HLA-DPB1; FCGR2C; HLA-DRB3; NOS2; TGFB2; IL4; IL1A; ITGB2
Chagas disease (American trypanosomiasis)
CD3E; CD3D; RELA; SERPINE1; MYD88; CD3D; IKBKG; SMAD2; TLR9; MAPK12; MAPK9
Toxoplasmosis
IFNGR1; TGFB3; MAP2K3; CD40; HLA-DOB; HLA-DRB3; TLR4; BCL2; IRGM1; IL12A
Tuberculosis
HLA-DRB4; STAT1; MAPK12; AKT2; LAMP2; IFNB1; LBP; ATP6V0B; PIK3C3; IFNA6
Hepatitis C
PDPK1; PIK3CB; CLDN18; PIK3CD; IFNA8; Ifna11; CLDN1; RXRA; CLDN9; IRF7
Influenza A
IFNA21; MAP2K4; PABPN1L; IFNA14; PIK3R1; CASP9; IRAK4; IFNGR1; HLA-DRA; IFNA1
Epstein-Barr virus infection
SNW1; PSMD11; MAPK10; CD44; ENTPD8; HDAC1; NCOR2; MAP3K14; PSMD4; RIPK1
Proteoglycans in cancer
MAP2K1; CAMK2B; FGFR1; MAPK11; ITGA5; GPC3; ACTB; GRB2; CDC42; PPP1CC

Protein Function

MAPK13 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK13 itself. We selected most functions MAPK13 had, and list some proteins which have the same functions with MAPK13. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RPS6KC1; PBK; PRKCHB; ABCC12; DHX57; ACTG2; PANK1B; DDX25; SLC27A5; NSFA
Function MAP kinase activity
Related Protein MAPK12B; MAPK7; NLK; MAPK8A; MAPK13; NLK2; NLK1; MAPK12; MAPK6; MAPK15
Function protein binding
Related Protein MST1R; PLK1S1; KLF12; NACA; FAM109B; RNF183; WFDC9; SH3PXD2B; EFNB1; AK8
Function protein serine/threonine kinase activity
Related Protein SNRKA; SLK; IRAK3; AAK1; MAPK6; CDK1; PRKCB; MAPKAPK2; CSNK1G2A; MAP3K14

Interacting Protein

MAPK13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK13.
PRKD1; FPR1; saicar; PKM; ATF2; MAPKAPK3; Pkd1; MAP3K4; GPX4; SMAD4; ANKLE2; AKIP1; pi3p