Recombinant Mouse Mapk13 Protein, Myc/DDK-tagged

Cat.No. : Mapk13-3940M
Product Overview : Purified recombinant protein of mouse full-length mitogen-activated protein kinase 13 (Mapk13), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 42.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Mapk13 mitogen-activated protein kinase 13 [ Mus musculus (house mouse) ]
Official Symbol : Mapk13
Synonyms : MAPK13; mitogen-activated protein kinase 13; MAPK 13; MAP kinase 13; SAPK/Erk/kinase 4; MAP kinase p38 delta; p38 delta MAP kinase; stress-activated protein kinase 4; mitogen activated protein kinase 13; mitogen-activated protein kinase p38 delta; SAPK4; Serk4
Gene ID : 26415
mRNA Refseq : NM_011950
Protein Refseq : NP_036080
UniProt ID : Q9Z1B7

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