med24
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  • Official Full Name
  • mediator complex subunit 24
  • Background
  • This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
  • Synonyms
  • MED24; mediator complex subunit 24; cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa , CRSP4, THRAP4, thyroid hormone receptor associated protein 4; mediator of RNA polymerase II transcription subunit 24; CRSP100; DRIP100; KIAA0130
Cat.#:MED24-4472HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MED24 Protein, GST-tagged
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Cat.#:MED24-10HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MED24 protein, MYC/DDK-tagged
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Cat.#:MED24-823HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MED24
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Cat.#:MED24-9696MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED24 Protein
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Cat.#:MED24-3637RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MED24 Protein
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Cat.#:MED24-3016CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MED24
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Cat.#:MED24-3603ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED24
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Cat.#:MED24-4386HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MED24 293 Cell Lysate
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Involved Pathway

MED24 involved in several pathways and played different roles in them. We selected most pathways MED24 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED24 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
NCOA1; PFKFB2; PLCB3; TP53; ATP1B1; ATP1A3; DIO2; CASP9; HDAC1; PRKACB

Protein Function

MED24 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, histone acetyltransferase activity, ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED24 itself. We selected most functions MED24 had, and list some proteins which have the same functions with MED24. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription cofactor activity
Related Protein MED10; MED19; MDT-19; CRSP7; MED24; MED22; MED14; MED13A; MED8; MED1
Function histone acetyltransferase activity
Related Protein TAF1; TAF1L; KAT7A; KAT2B; ATF2; KAT2A; HTATIP; NCOA2; HAT1; CDYL
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein ACTN1; TADA3; ACTN4; PSMC3IP; AASS; MED4; ENY2; KDM1A; MED14; NCOA3
Function protein binding
Related Protein YWHAQ; OBFC1; FAM129A; USP13; SH3BP1; MLKL; RHO; MEP1B; IER3; POLR1C
Function receptor activity
Related Protein PAQR5; MED16; EIF2D; CADM2; CADM3; PAQR4; FAS; TREM2; CD93; NLGN2B
Function thyroid hormone receptor binding
Related Protein MED12; OASL; NCOA3; MED24; GTF2B; THRAP3; FUS; PRMT2; MED4; NR0B2
Function transcription cofactor activity
Related Protein MXD1; KAT2B; LDB1B; ZNF763; ZFP667; TMF1; RFXANK; MED1; PRKCBP1L; ZNF671
Function ubiquitin protein ligase activity
Related Protein HACE1; TMEM189; MED1; UBE2S; RNF6; MED20; COP1; BRAP; RAD18; RNF144A
Function vitamin D receptor binding
Related Protein MED14; TAF11; MED4; MED24; TAF7; THRAP3; MED17; SNW1; RXRA; RUNX2B

Interacting Protein

MED24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED24 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED24.
MED10; CDK19; MED19; CDK8; MED9; Dlg4; MED14; CCNC; SMAD2; SMAD1; MED25; MED16

MED24 Related Articles

Chen, YR; Chen, CL; et al. Mitochondrial complex II in the post-ischemic heart - Oxidative injury and the role of protein S-glutathionylation. JOURNAL OF BIOLOGICAL CHEMISTRY 282:32640-32654(2007).