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MED24

  • Official Full Name

    mediator complex subunit 24

  • Overview

    This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
  • Synonyms

    MED24; mediator complex subunit 24; cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa , CRSP4, THRAP4, thyroid hormone receptor associated protein 4; mediator of RNA polymerase II transcription subunit 24; CRSP100; DRIP100; KIAA0130;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED24-10H Recombinant Human MED24 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MED24-823H Recombinant Human MED24 Mammalian Cell His
Human MED24-4386HCL Recombinant Human MED24 293 Cell Lysate HEK293 N/A
Human MED24-4472H Recombinant Human MED24 Protein, GST-tagged Wheat Germ GST
Human MED24-350H Recombinant Human MED24 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MED24-6244HF Recombinant Full Length Human MED24 Protein, GST-tagged In Vitro Cell Free System GST 989 amino acids
Human MED24-3452H Recombinant Human MED24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MED24-3452H-B Recombinant Human MED24 Protein Pre-coupled Magnetic Beads HEK293
Mouse MED24-9696M Recombinant Mouse MED24 Protein Mammalian Cell His
Mouse MED24-5452M Recombinant Mouse MED24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Med24-4016M Recombinant Mouse Med24 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MED24-5452M-B Recombinant Mouse MED24 Protein Pre-coupled Magnetic Beads HEK293
Rat MED24-3637R Recombinant Rat MED24 Protein Mammalian Cell His
Rat MED24-3293R-B Recombinant Rat MED24 Protein Pre-coupled Magnetic Beads HEK293
Rat MED24-3293R Recombinant Rat MED24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MED24-3603Z Recombinant Zebrafish MED24 Mammalian Cell His
Chicken MED24-3016C Recombinant Chicken MED24 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MED24 Related Articles

MED24 involved in several pathways and played different roles in them. We selected most pathways MED24 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Thyroid hormone signaling pathwayPLCB1;PIK3R2;WNT4;STAT1;MTOR;PRKCA;ATP1B3;PLCG2;SIN3A

MED24 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, histone acetyltransferase activity, ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED24 itself. We selected most functions MED24 had, and list some proteins which have the same functions with MED24. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription cofactor activityMED30;MED1;MED13L;MED26;MED10;FOXH1;MED18;CRSP7;MED19
histone acetyltransferase activityTAF1L;KAT8;NCOA1;EP300;KAT6B;KAT7A;HTATIP;CREBBP;KAT7
ligand-dependent nuclear receptor transcription coactivator activityZCCHC12;CARM1;PUS1;LRP2BP;DCAF6;MED14;MED1;KDM1A;FGF2
protein bindingFGFR3;NPC1;MAGEA1;ZFP335;NGDN;ARNTL1B;SEMA4C;AVPR1A;IMP3
receptor activityRPA1;CADM1;CADM2;NLGN4Y;PAQR5A;TNFRSF10B;VMN1R41;SLC1A5;JMJD6
thyroid hormone receptor bindingNUP62;HMGN3;MED12;MED17;MED30;TRIP12;TAF11;NCOR1;MED4
transcription cofactor activityIRF3;RFXANK;ZFP710;AIRE;FAM48A;ZNF212;MED13;ZFP865;PSMC5
ubiquitin protein ligase activityZSWIM2;ZNRF2;PELI1;TRIM2;RNF121;MSL2A;UBE2T;RNF115;HACE1
vitamin D receptor bindingSNW1;THRAP3;MED16;RUNX2B;MED14;MED17;RXRA;TAF7;MED24

MED24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED24 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED24.

MED10; CDK19; MED19; CDK8; MED9; Dlg4; MED14; CCNC; SMAD2; SMAD1; MED25; MED16

Chen, YR; Chen, CL; et al. Mitochondrial complex II in the post-ischemic heart - Oxidative injury and the role of protein S-glutathionylation. JOURNAL OF BIOLOGICAL CHEMISTRY 282:32640-32654(2007).
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