ncor2
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  • Official Full Name
  • nuclear receptor corepressor 2
  • Background
  • SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
  • Synonyms
  • NCOR2; nuclear receptor corepressor 2; nuclear receptor co repressor 2; CTG26; SMRT; SMRTE; TNRC14; TRAC 1; CTG repeat protein 26; T3 receptor-associating factor; thyroid-, retinoic-acid-receptor-associated corepressor; silencing mediator for retinoid and thyroid hormone receptors; TRAC; TRAC1; N-CoR2; TRAC-1; SMAP270; SMRTE-tau; FLJ25011
Cat.#:NCOR2-1889HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nuclear Receptor Corepressor 2, GST-tagged
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Cat.#:NCOR2-1619ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NCOR2
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Cat.#:Kit-0618Tag:
Source (Host):Species:
Product nameNCOR2 Gene Knockdown Quantification Kit
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Involved Pathway

NCOR2 involved in several pathways and played different roles in them. We selected most pathways NCOR2 participated on our site, such as Notch signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
ADAM17; ADAM12; NOTCH4; DTX3L; MFAP5; DLK1; HER12; NOTCH1A; EP300; MIB1
Epstein-Barr virus infection
HDAC1; IFNG; POLR3GL; PIK3CD; POLR2D; HLA-DQA1; CR2; POLR1C; HSPA1A; POLR2J2

Protein Function

NCOR2 has several biochemical functions, for example, DNA binding, Notch binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOR2 itself. We selected most functions NCOR2 had, and list some proteins which have the same functions with NCOR2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DBX1A; FOXD1; NKX2-1; LBX1B; KDM5C; HMX4; ZFP36L3; CLOCKA; RXRBB; ZBTB2
Function Notch binding
Related Protein JAG1B; CHAC1; NOTCH4; JAG1A; EGFL7; JAG2B; HIF1AN; JAG2; DLL1; NOTCH1
Function histone deacetylase binding
Related Protein SFPQ; RFXANK; MYOCD; BRMS1L; HDAC3; NKX3; RBBP4; BRMS1LA; NKX2-5; HEY2
Function ligand-dependent nuclear receptor binding
Related Protein NR1H4; SLC30A9; UBA3; SMARCD3; ARID1A; NCOR1; PROX1; NCOA3; JUND; TADA3
Function protein N-terminus binding
Related Protein ID1; DAXX; YWHAQ; RPA3; DCN; HAX1; ERCC2; TDRD7; EIF5A; TBL1XR1
Function protein binding
Related Protein KDRL; TGFB1I1; PACSIN1; NEU2; KCNA4; FIS1; RAF1; NKX3; KCTD5; PMM1
Function transcription corepressor activity
Related Protein CREG1; KDM5B; CDYL; WTIP; CSDA; SP100; SAP18; TRIM22; PBXIP1; CTBP2A
Function transcription factor binding
Related Protein HEY1; CRY1; HIF1A; KDM1A; PIAS2; TP73; JUNBA; KEAP1; NLRP3; PARK7

NCOR2 Related Articles

Carlberg, C; Dunlop, TW; et al. The impact of chromatin organization of vitamin D target genes. ANTICANCER RESEARCH 26:2637-2645(2006).
Widerak, M; Ghoneim, C; et al. The aryl hydrocarbon receptor activates the retinoic acid receptor alpha through SMRT antagonism. BIOCHIMIE 88:387-397(2006).