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NCOR2

Official Full Name

nuclear receptor corepressor 2
Overview

SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
Synonyms

NCOR2; nuclear receptor corepressor 2; nuclear receptor co repressor 2; CTG26; SMRT; SMRTE; TNRC14; TRAC 1; CTG repeat protein 26; T3 receptor-associating factor; thyroid-, retinoic-acid-receptor-associated corepressor; silencing mediator for retinoid and thyroid hormone receptors; TRAC; TRAC1; N-CoR2; TRAC-1; SMAP270; SMRTE-tau; FLJ25011;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	NCOR2-1889H	Recombinant Human Nuclear Receptor Corepressor 2, GST-tagged	E.coli	GST	Inquiry
Zebrafish	NCOR2-1619Z	Recombinant Zebrafish NCOR2	Mammalian Cell	His	Inquiry
	Kit-0618	NCOR2 Gene Knockdown Quantification Kit		N/A	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
NCOR2 Related Signal Pathway

NCOR2 involved in several pathways and played different roles in them. We selected most pathways NCOR2 participated on our site, such as Notch signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Notch signaling pathway	DLC;DVL1B;APH1C;DTX1;RBPJB;ADAM17A;NOTCH1A;DLA;CTBP2A
Epstein-Barr virus infection	YWHAH;PIK3R3;NEDD4;TBPL1;IL10RA;POLR2H;EIF2AK1;GTF2B;ITGAL

NCOR2 has several biochemical functions, for example, DNA binding, Notch binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOR2 itself. We selected most functions NCOR2 had, and list some proteins which have the same functions with NCOR2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HOXC6B;HIST1H3F;ZZZ3;CDK5R2;SPI1A;POLR2J;VDRB;CREMB;CERS3B
Notch binding	SNW1;DLL3;CHAC1;JAG1;JAG1B;NOV;DNER;GALNT11;EGFL7
histone deacetylase binding	SIRT2;SKOR2;DHX36;CAMTA2;KAT2B;XBP1;TAL1;BCOR;SIX3
ligand-dependent nuclear receptor binding	SMARCD3;NCOR1;TADA3;TRIM24;TRIP4;SMARCE1;NCOA1;NR1H4;UBA3
protein N-terminus binding	UNC13A;RBPJ;SUV39H1;PDCD10;PARP1;MYO7A;ERCC4;ATM;EXOC5
protein binding	IGSF8;CLPB;PPP4R2;UHRF1;ZNF622;MANBAL;LOC780933;PLXDC1;MEIOB
transcription corepressor activity	ZHX2;TMEM38A;SMARCA4;PBXIP1;ZNF593;KCNA3;NANOG;RUNX1T1;NR0B1
transcription factor binding	BCL2;DIP2BA;SOX8;PPP1R13B;JUNBB;HES2;GPX3;GTF2A2;EPN1

NCOR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOR2.

Research Area

Carlberg, C; Dunlop, TW; et al. The impact of chromatin organization of vitamin D target genes. ANTICANCER RESEARCH 26:2637-2645(2006).

Widerak, M; Ghoneim, C; et al. The aryl hydrocarbon receptor activates the retinoic acid receptor alpha through SMRT antagonism. BIOCHIMIE 88:387-397(2006).