nrp1
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  • Official Full Name
  • neuropilin 1
  • Background
  • This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms
  • NRP1; neuropilin 1; NP1; NRP; BDCA4; CD304; VEGF165R; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor
Cat.#:NRP1-670HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Neuropilin 1
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Cat.#:NRP1-090HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP1, His tagged
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Cat.#:NRP1-3346HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP1, Fc tagged
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Cat.#:NRP1-644HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human NRP1, His-tagged
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Cat.#:NRP1-803HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRP1 protein, His-tagged
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Cat.#:NRP1-804HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRP1 protein, His-tagged
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Cat.#:NRP1-8119HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP1 protein, His & Avi-tagged, Biotinylated
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Cat.#:NRP1-10898MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NRP1 Protein
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Cat.#:Nrp1-613MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Nrp1 Protein, His-tagged
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Cat.#:Nrp1-805MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nrp1 protein, His-tagged
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Cat.#:Nrp1-806MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nrp1 protein, His-tagged
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Cat.#:Nrp1-807MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nrp1 protein, His-tagged
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Cat.#:Nrp1-808MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nrp1 protein, His-tagged
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Cat.#:Nrp1-8118MTag:mFc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Nrp1 protein, mFc-tagged
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Cat.#:NRP1-4084RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NRP1 Protein
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Cat.#:Nrp1-809RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nrp1 protein, His-tagged
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Cat.#:Nrp1-810RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nrp1 protein, His-tagged
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Cat.#:Nrp1-811RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nrp1 protein, His & GST-tagged
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Cat.#:Nrp1-812RTag:His/MBP
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nrp1 protein, His & MBP-tagged
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Cat.#:NRP1-1218CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NRP1 Protein, His-tagged
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Cat.#:NRP1-157CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NRP1, Fc tagged
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Cat.#:NRP1-158CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NRP1, LEVLFQ tagged
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Cat.#:NRP1-3104RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NRP1 Protein, His-tagged
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Cat.#:NRP1-6346CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NRP1
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Cat.#:NRP1-1763HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRP1 cell lysate
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Cat.#:NRP1-811CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NRP1 cell lysate
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Cat.#:CSC-P0470Tag:
Source (Host):Species:
Product nameAnti-Human NRP1 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0471Tag:
Source (Host):Species:
Product nameAnti-Human NRP1 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0472Tag:
Source (Host):Species:
Product nameAnti-Human NRP1 scFv Stable Cell Line-CHO
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Involved Pathway

NRP1 involved in several pathways and played different roles in them. We selected most pathways NRP1 participated on our site, such as Axon guidance, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
KBTBD7; PAK4; NFATC4; CDK5; SRGAP1; PPP3R2; SPTBN1; FRS2B; EPHA2A; EFNB3
HTLV-I infection
TNFRSF1A; WNT5A; RB1; Adcy4; FZD6; ETS1; FZD2; CDC20; KRAS; PIK3CB

Protein Function

NRP1 has several biochemical functions, for example, coreceptor activity, cytokine binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRP1 itself. We selected most functions NRP1 had, and list some proteins which have the same functions with NRP1. You can find most of the proteins on our site.
Function
Related Protein
Function coreceptor activity
Related Protein CD80; CD8B; RAMP2; RGMD; CCR8; PVRL2; CD4; TGFBR3; ACKR3B; CXCR7
Function cytokine binding
Related Protein CD74; Fzd4; IL31RA; CSF1R; CHRD; LIFR; ELANE; CNTFR; CXCR4; GBP1
Function growth factor binding
Related Protein ACVR1C; TEK; HTRA1A; KDR; NKD2; GHRHR; SDCBP; RHBDF2; FLT1; IGFBP2A
Function heparin binding
Related Protein FGF1A; SOST; LTF; BMP4; PLA2G2D; WISP1B; LPA; RPL29; CLEC3B; FGFR1A
Function metal ion binding
Related Protein PITPNM1; SCRT2; MGAT4A; SLC25A25A; CYB561D1; MICAL2B; PLEKHM1P; GLRX3; BTK; AMY1A
Function protein binding
Related Protein UBE2D4; RAB3C; RPS3A; CCDC42; SPPL3; MTERF; GRIN2D; LANCL1; RPL10A; NANOS2
Function semaphorin receptor activity
Related Protein PLXNB2B; PLXNA1B; PLXND1; NRP2A; NRP2B; NRP1A; PLXNB2A; PLXNA1; Plxna2; PLXNC1
Function vascular endothelial growth factor binding
Related Protein PDGFRB; KDR; NRP1; PDGFRA
Function vascular endothelial growth factor-activated receptor activity
Related Protein NRP2B; PDGFRA; NRP2A; KDR; NRP2; NRP1A; FLT3; FLT4; FLT1; NRP1

Interacting Protein

NRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRP1.
VEGFA; KDR; FLNA; FLT1; RPL27; ptsN1; CSNK2A2

NRP1 Related Articles

Weekes, CD; Beeram, M; et al. A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. INVESTIGATIONAL NEW DRUGS 32:653-660(2014).
Venkova, K; Christov, A; et al. Semaphorin 3A Signaling Through Neuropilin-1 Is an Early Trigger for Distal Axonopathy in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 73:702-713(2014).