| Description : |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
96.5 kDa |
| Protein Length : |
923 |
| AA Sequence : |
MERGLPLLCAVLALVLAPAGAFRND KCGDTIKIESPGYLTSPGYPHSYHP SEKCEWLIQAPDPYQRIMINFNPHF DLEDRDCKYDYVEVFDGENENGHFR GKFCGKIAPPPVVSSGPFLFIKFVS DYETHGAGFSIRYEIFKRGPECSQN YTTPSGVIKSPGFPEKYPNSLECTY IVFVPKMSEIILEFESFDLEPDSNP PGGMFCRYDRLEIWDGFPDVGPHIG RYCGQKTPGRIRSSSGILSMVFYTD SAIAKEGFSANYSVLQSSVSEDFKC MEALGMESGEIHSDQITASSQYSTN WSAERSRLNYPENGWTPGEDSYREW IQVDLGLLRFVTAVGTQGAISKETK KKYYVKTYKIDVSSNGEDWITIKEG NKPVLFQGNTNPTDVVVAVFPKPLI TRFVRIKPATWETGISMRFEVYGCK ITDYPCSGMLGMVSGLISDSQITSS NQGDRNWMPENIRLVTSRSGWALPP APHSYINEWLQIDLGEEKIVRGIII QGGKHRENKVFMRKFKIGYSNNGSD WKMIMDDSKRKAKSFEGNNNYDTPE LRTFPALSTRFIRIYPERATHGGLG LRMELLGCEVEAPTAGPTTPNGNLV DECDDDQANCHSGTGDDFQLTGGTT VLATEKPTVIDSTIQSEFPTYGFNC EFGWGSHKTFCHWEHDNHVQLKWSV LTSKTGPIQDHTGDGNFIYSQADEN QKGKVARLVSPVVYSQNSAHCMTFW YHMSGSHVGTLRVKLRYQKPEEYDQ LVWMAIGHQGDHWKEGRVLLHKSLK LYQVIFEGEIGKGNLGGIAVDDISI NNHISQEDCAKPADLDKKNPEIKID ETGSTPGYEGEGEGDKNISRKPGNV LKTLDPILITIIAMSALGVLLGAVC GVVLYCACWHNGMSERNLSALENYN FELVDGVKLKKDKLNTQSTYSEA |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
