Recombinant Human NRP1 protein, His-tagged
Cat.No. : | NRP1-2065H |
Product Overview : | Recombinant Human NRP1 (Phe22-Lys644) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Phe22 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 70.7 kDa. The protein migrates as 75-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Phe22-Lys644 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >92% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | NRP1 |
Official Symbol : | NRP1 |
Synonyms : | NRP1; neuropilin 1; neuropilin-1; CD304; NRP; VEGF165R; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; NP1; BDCA4; DKFZp781F1414; DKFZp686A03134 |
Gene ID : | 8829 |
mRNA Refseq : | NM_001024628 |
Protein Refseq : | NP_001019799 |
MIM : | 602069 |
UniProt ID : | O14786 |
Products Types
◆ Recombinant Protein | ||
NRP1-1290C | Acitve Recombinant Cynomolgus NRP1 protein(Met1-Gly613), hFc-tagged | +Inquiry |
NRP1-397H | Recombinant Human NRP1 Protein, Fc-tagged | +Inquiry |
NRP1-6210M | Recombinant Mouse NRP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Nrp1-4502M | Recombinant Mouse Nrp1 Protein, Myc/DDK-tagged | +Inquiry |
NRP1-3684H | Recombinant Human NRP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NRP1-811CCL | Recombinant Cynomolgus NRP1 cell lysate | +Inquiry |
NRP1-1763HCL | Recombinant Human NRP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionIt may be involved in the processes of angiography, inflammation, fibrosis and other processes in the lungs, and is related to the occurrence and development of lung diseases.
The high expression of NRP1 may be related to factors such as the aggressiveness of the tumor and the increased angiogenesis of the tumor.
Yes, NRP1, as a molecule with important biological functions and clinical significance, can be targeted as a target therapy.
This protein can be used as a potential marker in clinical diagnosis for tumor diagnosis and prognosis evaluation.
Yes, NRP1 may be related to the metabolism of drugs, the response to drug treatment, etc., which affects the efficacy and side effects of drugs.
NRP1 may be involved in the regulation of autoimmune responses, inflammatory responses, etc., and is related to the occurrence and development of immune diseases.
Customer Reviews (3)
Write a reviewThe protein has a moderate molecular weight and is convenient to use.
NRP1 can be easily used and measured in experiment.
NRP1 has a high purity.
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