Description : |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
71.9 kDa |
AA Sequence : |
MERGLPLLCAVLALVLAPAGAFRND KCGDTIKIESPGYLTSPGYPHSYHP SEKCEWLIQAPDPYQRIMINFNPHF DLEDRDCKYDYVEVFDGENENGHFR GKFCGKIAPPPVVSSGPFLFIKFVS DYETHGAGFSIRYEIFKRGPECSQN YTTPSGVIKSPGFPEKYPNSLECTY IVFAPKMSEIILEFESFDLEPDSNP PGGMFCRYDRLEIWDGFPDVGPHIG RYCGQKTPGRIRSSSGILSMVFYTD SAIAKEGFSANYSVLQSSVSEDFKC MEALGMESGEIHSDQITASSQYSTN WSAERSRLNYPENGWTPGEDSYREW IQVDLGLLRFVTAVGTQGAISKETK KKYYVKTYKIDVSSNGEDWITIKEG NKPVLFQGNTNPTDVVVAVFPKPLI TRFVRIKPATWETGISMRFEVYGCK ITDYPCSGMLGMVSGLISDSQITSS NQGDRNWMPENIRLVTSRSGWALPP APHSYINEWLQIDLGEEKIVRGIII QGGKHRENKVFMRKFKIGYSNNGSD WKMIMDDSKRKAKSFEGNNNYDTPE LRTFPALSTRFIRIYPERATHGGLG LRMELLGCEVEAPTAGPTTPNGNLV DECDDDQANCHSGTGDDFQLTGGTT VLATEKPTVIDSTIQSGIKTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |