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Recombinant Human NRP1 protein, His-tagged

Cat.No. : NRP1-806H
Product Overview : Recombinant Human NRP1 protein (483-644aa) was fused to His-tag and expressed in E.coli.
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  • Gene Information
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Description : This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Source : E.coli
Species : Human
Tag : His
Form : Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Molecular Mass : 32 kDa
AA Sequence : EWLQIDLGEEKIVRGIIIQGGKHRE NKVFMRKFKIGYSNNGSDWKMIMDD SKRKAKSFEGNNNYDTPELRTFPAL STRFIRIYPERATHGGLGLRMELLG CEVEAPTAGPTTPNGNLVDECDDDQ ANCHSGTGDDFQLTGGTTVLATEKP TVIDSTIQSGIK
Purity : 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Store for up to 12 months at -20 to -80 centigrade as lyophilized powder. Short-term storage: Store at 2-8 centigrade for (1-2 weeks). Long-term storage: Aliquot and store at -20 to -80 centigrade for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.
If a different concentration is needed for your purposes please adjust the reconstitution
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.
Gene Name : NRP1
Official Symbol : NRP1
Synonyms : NP1; NRP; BDCA4; CD304; VEGF165R
Gene ID : 8829
mRNA Refseq : NM_003873.7
Protein Refseq : NP_003864.5
MIM : 602069
UniProt ID : O14786

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of NRP1 in lung disease? 12/01/2022

It may be involved in the processes of angiography, inflammation, fibrosis and other processes in the lungs, and is related to the occurrence and development of lung diseases.

What factors are associated with high NRP1 expression? 01/02/2022

The high expression of NRP1 may be related to factors such as the aggressiveness of the tumor and the increased angiogenesis of the tumor.

Can NRP1 be targeted for targeted therapy? 03/02/2021

Yes, NRP1, as a molecule with important biological functions and clinical significance, can be targeted as a target therapy.

What are the applications of NRP1 in clinical diagnosis? 10/29/2020

This protein can be used as a potential marker in clinical diagnosis for tumor diagnosis and prognosis evaluation.

Is NRP1 associated with drug therapy? 04/18/2020

Yes, NRP1 may be related to the metabolism of drugs, the response to drug treatment, etc., which affects the efficacy and side effects of drugs.

How is NRP1 related to immune diseases? 04/07/2020

NRP1 may be involved in the regulation of autoimmune responses, inflammatory responses, etc., and is related to the occurrence and development of immune diseases.

Customer Reviews (3)

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Reviews
05/24/2022

    The protein has a moderate molecular weight and is convenient to use.

    07/12/2021

      NRP1 can be easily used and measured in experiment.

      04/20/2021

        NRP1 has a high purity.

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