nthl1
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  • Official Full Name
  • nth endonuclease III-like 1 (E. coli)
  • Background
  • The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.
  • Synonyms
  • NTHL1; nth endonuclease III-like 1 (E. coli); nth (E.coli endonuclease III) like 1; endonuclease III-like protein 1; NTH1; OCTS3; Endonuclease III like protein 1; NTH 1; NTH endonuclease III Like 1; NTHL 1; NTHL1_HUMAN; OCTS 3; OTTHUMP00000158939
Cat.#:NTHL1-2488HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nth Endonuclease III-Like 1 (E. coli), His-tagged
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Cat.#:NTHL1-107HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NTHL1 Protein, His-tagged
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Cat.#:NTHL1-20HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTHL1 protein, MYC/DDK-tagged
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Cat.#:NTHL1-3545CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NTHL1
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Involved Pathway

NTHL1 involved in several pathways and played different roles in them. We selected most pathways NTHL1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
FEN1; MBD4; APEX1; PARP3; POLD1; LIG1; TDG; POLD3; SMUG1; POLE2

Protein Function

NTHL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NTHL1 itself. We selected most functions NTHL1 had, and list some proteins which have the same functions with NTHL1. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein NDUFS7; ISCU; POLA1; DNA2; NDUFS1; NUBPL; TYW1B; POLE; ISCUB; NUBP1
Function DNA N-glycosylase activity
Related Protein NEIL1; NTHL1; NEIL3; SMUG1; OGG1; TDG
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein NEIL1; HMGA1B; NEIL2; ALKBH1; HMGA1; APLF; APEX2; NTHL1; RPS3; NEIL3
Function double-stranded DNA binding
Related Protein TEF; MTERF; XRCC2; MTERFD2; KIN; SMAD2; TRP63; TP63; SP1; XRCC5
Function endonuclease activity
Related Protein RNASEL3; DCLRE1C; RNASE6; DROSHA; ENDOG; EXOG; RNASE4; SETMAR; EAR1; EME1
Function metal ion binding
Related Protein FYN; Car12; RBM22; BCL6; MAP3K4; FDPS; AOX3; OVOL2; ALOX5B.3; DMRT2
Function oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Related Protein SMUG1; NTHL1
Function protein binding
Related Protein EFEMP2; CLIC2; LGALSL; GATA1; XRN1; POLR1C; UBXN2B; RAB11A; TPSB2; RRAGB

Interacting Protein

NTHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTHL1.
GAPDHS; MYH7; RBL1; NUDT1; RNMTL1; RPL10; Rpl35; CAMKK1; Gspt1

NTHL1 Related Articles

De Summa, S; Pinto, R; et al. Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. CELL DEATH & DISEASE 5:-(2014).
Corral, R; Lewinger, JP; et al. Genetic Variation in the Base Excision Repair Pathway, Environmental Risk Factors, and Colorectal Adenoma Risk. PLOS ONE 8:-(2013).