This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
PCDHB10 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB10 itself. We selected most functions PCDHB10 had, and list some proteins which have the same functions with PCDHB10. You can find most of the proteins on our site.
Function calcium ion binding
Related Protein FAT1A; CD248; EDEM1; CMLC1; PCDH15; LDLRB; SCGN; GM5077; GSNA; S100U
PCDHB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB10.
PCDHB10 Related Articles
Zhao, Y; Yang, YH; et al. A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer. CANCER RESEARCH 74:5103-5117(2014).
Wojtalewicz, N; Sadeqzadeh, E; et al. A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding. PLOS ONE 9:-(2014).