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Official Full Name phosphodiesterase 4D, cAMP-specific
Background This gene encodes one of four mammalian counterparts to the fruit fly dunce gene. The encoded protein has 3,5-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Synonyms PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; cAMP-specific 3,5-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila);
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE4D-1687H Recombinant Human PDE4D Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pde4d-4747M Recombinant Mouse Pde4d Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PDE4D-10H Recombinant Human PDE4D protein, GST-tagged Insect Cell GST
    Human PDE4D-1601H Recombinant Human PDE4D, GST-tagged E.coli GST
    Human PDE4D-28756TH Recombinant Human PDE4D N/A
    Human PDE4D-303H Recombinant Human PDE4D Protein, His/GST-tagged E.coli His/GST
    Human PDE4D-3350HCL Recombinant Human PDE4D 293 Cell Lysate HEK293 N/A
    Human PDE4D-478H Recombinant Human PDE4D, GST-tagged, Active Sf9 Insect Cell GST
    Rat PDE4D-4332R Recombinant Rat PDE4D Protein Mammalian Cell His

    PDE4D involved in several pathways and played different roles in them. We selected most pathways PDE4D participated on our site, such as Purine metabolism, cAMP signaling pathway, Morphine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism URAH; URAD; AK4; NPR2; NPR1; ENTPD3; CANT1B; ADAL; GDA; PKMB
    cAMP signaling pathway PDE3A; PIK3R1; RAC3; GPR119; ORAI1; PIK3CG; RAC2; NPR1; ATP1A4; PDE3B
    Morphine addiction PRKACA; OPRM1; GNAO1; GABRB2; GNB4; ADRBK2; GNG10; PRKACB; PDE1A; PRKCB

    PDE4D has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4D itself. We selected most functions PDE4D had, and list some proteins which have the same functions with PDE4D. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activity PDE3A; PDE7A; PDE4D; PDE7B; USB1; TDP2B; PDE4A; PDE8B; PDE8A; PDE4C
    3,5-cyclic-nucleotide phosphodiesterase activity PDE5AB; PDE10A; PDE11A; PDE6D; PDE5A; PDE8B; PDE4D; PDE8A; PDE9A; PDE3B
    ATPase binding FXYD7; ATPIF1; FXYD4; CAV1; PTPN3; ATP6V0A1; DRD1A; FBL; NKAIN1; TAF9
    SH3 domain binding PDCD6IP; USP8; SGIP1; CABYR; PTPN12; DRD4; ENKUR; ABL1; MVB12A; SHANK2
    beta-2 adrenergic receptor binding BDKRB2; PDE4D; NEDD4; SLC9A3R1; GNAS
    drug binding FOLR1; PIGC; UGT1A7; GPR30; MT2A; MTOR; SRP54; DRD3; GLRB; PDE4C
    enzyme binding KPNB1; UGT1A6; CASP2; AXIN2; USF1; NLRP1; BLZF1; PAWR; EHHADH; KMT2E
    ion channel binding LYN; PACS2; DIAP1; TRPC1; CHERP; PACS1; KCNB1; SCN3B; LRRK2; CAMK2D
    metal ion binding DNMT3B; ZNF394; ZNF474; TNNI3K; TRIM2A; ZNF718; MKRN4; RHEBL1; PAN3; ZFP82
    protein binding NEDD4; PMF1; ZKSCAN4; PSG5; FAM103A1; HAND1; RMND1; SLC6A12; FASTK; ILKAP
    scaffold protein binding KCNQ1; TREM1; VIM; KRT5; DLG4; GRID2; PDE4D; DSP; MAPK3; SHANK3
    ubiquitin protein ligase binding BAG5; TRIM28; UBE2B; UBE2J2; DNAJA1; UBE2C; SKI; ATP6V0C; PRKAR1A; RNF20

    PDE4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4D here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4D.

    COIL; MAGEA6; GOLGA8F; GOLGA8DP; TRAF1; Bub1; AKAP12; SHANK2; q8d0r7_yerpe; ARRB2

    Nagasaki, K; Iida, T; et al. PRKAR1A Mutation Affecting cAMP-Mediated G Protein-Coupled Receptor Signaling in a Patient with Acrodysostosis and Hormone Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97:E1808-E1813(2012).
    Dostaler-Touchette, V; Bedard, F; et al. Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland. JOURNAL OF DAIRY SCIENCE 92:3757-3765(2009).

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