PDE4D-478H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant human PDE4D (225-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 82 kDa.
Description :
PDE4D is a member of the phosphodiesterase (PDE) family that is cAMP-specific and has homology to the "dunce" gene of Drosophila. PDE4D is expressed in both cytosolic and particulate fractions in the cell and Rolipram, a specific PDE4 inhibitor, inhibits and significantly lowers the IC50 for the cytosolic forms of the enzyme. TNFα upregulates the basal expression of PDE4D in HUVEC. PDE4D, which is not detected in untreated cells, accumulates beginning 4 hours after TNFα treatment and increased by 24 hours. Mice deficient in PDE4D exhibit delayed growth as well as reduced viability and female fertility.
Source :
Sf9 insect cells using baculovirus.
Sequence :
225-end.
Applications :
PDE Assay.
Storage And Stability :
Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.