Recombinant Human PDE4D

• Cat.No.: PDE4D-28756TH
• Product Overview: Recombinant full length Human PDE4D2 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, 103 kDa.

Specification

• Description: This gene encodes one of four mammalian counterparts to the fruit fly dunce gene. The encoded protein has 3,5-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
• Biological activity: Specific Activity: 36365 pmol/min/μg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: PDE4D phosphodiesterase 4D, cAMP-specific [ Homo sapiens ]
• Official Symbol: PDE4D
• Synonyms: PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3, phosphodiesterase 4D, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3); cAMP-specific 3,5-cyclic phosphodiesterase 4D; phosphodiesterase E3 dunce homolog (Drosophila)
• Gene ID: 5144
• mRNA Refseq: NM_001104631
• Protein Refseq: NP_001098101
• MIM: 600129
• Uniprot ID: Q08499
• Chromosome Location: 5q12
• Pathway: DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
• Function: 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; drug binding; hydrolase activity