PHKB

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PHKB

Official Full Name phosphorylase kinase, beta
Background Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.
Synonyms PHKB; phosphorylase kinase, beta; phosphorylase b kinase regulatory subunit beta; DKFZp781E15103; FLJ41698; Phosphorylase kinase B; Phosphorylase kinase beta polypeptide; Phosphorylase kinase beta subunit; OTTHUMP00000164134; phosphorylase kinase beta-subunit; phosphorylase kinase subunit beta
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Phkb-200M Recombinant Mouse Phkb Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human PHKB-3423H Recombinant Human PHKB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse PHKB-12739M Recombinant Mouse PHKB Protein Mammalian Cell His
    Rhesus Macaque PHKB-3411R Recombinant Rhesus monkey PHKB Protein, His-tagged Mammalian Cell His
    Chicken PHKB-1757C Recombinant Chicken PHKB Mammalian Cell His

    PHKB involved in several pathways and played different roles in them. We selected most pathways PHKB participated on our site, such as Calcium signaling pathway, Insulin signaling pathway, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway CACNA1BA; HTR7; ITPR3; ADRA1D; NOS2; CALM; CALM1A; GRPR; PTGFR; PLCE1
    Insulin signaling pathway SREBF1; EIF4E2RS1; MKNK2B; RAF1; FLOT1B; FOXO1; EIF4E1B; SHC2; PIK3R3A; PRKACAA
    Glucagon signaling pathway SLC2A2; CALM2; PPP4C; PPP3CB; LDHAL6A; GYS2; GNAQ; PRKAA2; CALML3; CAMK2B

    PHKB has several biochemical functions, for example, calmodulin binding, catalytic activity, contributes_to phosphorylase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKB itself. We selected most functions PHKB had, and list some proteins which have the same functions with PHKB. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding ASPM; ARPP21; PHKG1; PDE1A; SLC14A2; STRN; MAPKAPK2B; MYH11; MYO10; CNN3A
    catalytic activity GMPR2; PFKFB4L; PBLD2; PGAM1B; ISOC2; CKMA; PGGT1B; AGXT2; ZRANB3; HYAL6
    contributes_to phosphorylase kinase activity PHKB; PHKA1
    phosphorylase kinase activity PHKG1; PHKG2; PHKA2; PHKB; PHKG1B; PHKG1A

    PHKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKB here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKB.

    CALM1

    de Luna, N; Brull, A; et al. PYGM expression analysis in white blood cells: A complementary tool for diagnosing McArdle disease?. NEUROMUSCULAR DISORDERS 24:1079-1086(2014).
    Ammendola, M; Sacco, R; et al. Correlation between Serum Tryptase, Mast Cells Positive to Tryptase and Microvascular Density in Colo-Rectal Cancer Patients: Possible Biological-Clinical Significance. PLOS ONE 9:-(2014).

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