| Official Full Name | phosphorylase kinase, beta |
| Background | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively. |
| Synonyms | PHKB; phosphorylase kinase, beta; phosphorylase b kinase regulatory subunit beta; DKFZp781E15103; FLJ41698; Phosphorylase kinase B; Phosphorylase kinase beta polypeptide; Phosphorylase kinase beta subunit; OTTHUMP00000164134; phosphorylase kinase beta-subunit; phosphorylase kinase subunit beta |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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PHKB involved in several pathways and played different roles in them. We selected most pathways PHKB participated on our site, such as Calcium signaling pathway, Insulin signaling pathway, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | CACNA1BA; HTR7; ITPR3; ADRA1D; NOS2; CALM; CALM1A; GRPR; PTGFR; PLCE1 |
| Insulin signaling pathway | SREBF1; EIF4E2RS1; MKNK2B; RAF1; FLOT1B; FOXO1; EIF4E1B; SHC2; PIK3R3A; PRKACAA |
| Glucagon signaling pathway | SLC2A2; CALM2; PPP4C; PPP3CB; LDHAL6A; GYS2; GNAQ; PRKAA2; CALML3; CAMK2B |
PHKB has several biochemical functions, for example, calmodulin binding, catalytic activity, contributes_to phosphorylase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKB itself. We selected most functions PHKB had, and list some proteins which have the same functions with PHKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | ASPM; ARPP21; PHKG1; PDE1A; SLC14A2; STRN; MAPKAPK2B; MYH11; MYO10; CNN3A |
| catalytic activity | GMPR2; PFKFB4L; PBLD2; PGAM1B; ISOC2; CKMA; PGGT1B; AGXT2; ZRANB3; HYAL6 |
| contributes_to phosphorylase kinase activity | PHKB; PHKA1 |
| phosphorylase kinase activity | PHKG1; PHKG2; PHKA2; PHKB; PHKG1B; PHKG1A |
PHKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKB here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKB.
CALM1
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