pigk
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  • Official Full Name
  • phosphatidylinositol glycan anchor biosynthesis, class K
  • Background
  • This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
  • Synonyms
  • PIGK; phosphatidylinositol glycan anchor biosynthesis, class K; phosphatidylinositol glycan, class K; GPI-anchor transamidase; GPI transamidase subunit; GPI8; hGPI8; PIG-K; GPI8 homolog; phosphatidylinositol-glycan biosynthesis class K protein; MGC22559
Cat.#:PIGK-1706HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIGK, His-tagged
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Cat.#:PIGK-12781MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIGK Protein
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Cat.#:PIGK-3427RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIGK Protein, His-tagged
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Cat.#:PIGK-2935CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIGK
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Cat.#:PIGK-373ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIGK
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Cat.#:PIGK-3197HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIGK 293 Cell Lysate
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Involved Pathway

PIGK involved in several pathways and played different roles in them. We selected most pathways PIGK participated on our site, such as Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGK were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Attachment of GPI anchor to uPAR
PIGK
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
PIGH; PIGU; PIGN; PIGZ; PIGK; PIGP; PIGO; PIGV; PIGB; PIGC
Metabolic pathways
FUT8A; DLDH; COQ3; UQCRC2A; QDPRB1; CERS5; POLR3D; SPHK1; GNSB; CEL.1
Metabolism of proteins
SMC6; TRAPPC4; TIMM23; KLK13; PFDN2; ANKRD28; MUC4; LMAN2L; CPE; DCP2
Post-translational modification: synthesis of GPI-anchored proteins
PIGK
Post-translational protein modification
ST6GALNAC1.2; ZNF408; PREB; TRAPPC1; TRAPPC10; NAPG; MCFD2; SCMH1; ADAMTS5; CNIH

Protein Function

PIGK has several biochemical functions, for example, contributes_to GPI anchor binding, GPI-anchor transamidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGK itself. We selected most functions PIGK had, and list some proteins which have the same functions with PIGK. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to GPI anchor binding
Related Protein GPAA1; PIGK
Function GPI-anchor transamidase activity
Related Protein FAM108B; PIGK; MBLAC1; NUDT13; FAM108A; PIGU; FAM108C
Function cysteine-type peptidase activity
Related Protein SENP3B; CTSC; CTSJ; SENP7; CASP6L1; CTSSA; SENP8; CASP3A; Ctsl; USP17L1P
Function protein binding
Related Protein CENPL; SQSTM1; PLAA; RAMP1; KRT5; VPS4B; ATG7; SMARCD3; SNAP91; LNX2
Function protein disulfide isomerase activity
Related Protein P4HB; PDIA6; PDILT; PDIA4; TXNDC11; PIGK; TMX1; GLRX2; ERO1L; PDIA5

Interacting Protein

PIGK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGK here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGK.
ALPP; midostaurin; PIGS