PIK3CG
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Official Full Name
phosphoinositide-3-kinase, catalytic, gamma polypeptide
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Overview
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. -
Synonyms
PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; p110gamma; p120-PI3K; PI3K-gamma; p110-gamma; PI3-kinase subunit gamma; ptdIns-3-kinase subunit gamma; 1-phosp;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PIK3CG Related Signal Pathway
PIK3CG involved in several pathways and played different roles in them. We selected most pathways PIK3CG participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PI4KA;ITPKB;MTMR1A;NUDT3B;IPMKB;PIK3C2A;IPMK;PI4K2B;PLCZ1 |
| ErbB signaling pathway | CAMK2G;PRKCBA;ERBB4;AKT2;PTK2AA;RAF1B;PLCG1;ABL2;CBLC |
| Ras signaling pathway | KRAS;GNG7;PLA2G2E;FGF7;PLCE1;MAP2K2;PAK7;RAB5B;SHC1 |
| Rap signaling pathway | FGF8;ITGAL;LCP2;BRAF;PRKCB;RAP1GAP;RALB;PDGFD;GNAS |
| cGMP-PKG signaling pathway | CALM1;GNAI1;MYLK3;ATP2B4;PPIF;CALM3;OPRD1;PLCB4;PDE3A |
| cAMP signaling pathway | ACOX3;CALM4;PDE4B;ARAP3;CNGA1;HTR1E;CALM1;GNAI1;HTR1B |
| Chemokine signaling pathway | CXCR3;JAK2;CXCL8;CCL2;CCL14;SRC;XCL2;HCK;PIK3R1 |
| HIF- signaling pathway | HIF1A;INS2;NOX1;VEGFA;MKNK1;IGF1R;IFNGR1;INSR;SERPINE1 |
| FoxO signaling pathway | BCL6;BNIP4;S1PR4;S1PR1;BNIP3;MAP2K2A;SGK1;HRASA;RAG1 |
| Phosphatidylinositol signaling system | PIK3R3A;INPP5B;ITPKA;IMPAD1;ITPKB;IPPK;PI4K2B;MTMR3;PLCB1 |
| Sphingolipid signaling pathway | SPTLC1;FCER1A;PRKCZ;PLCB2;GNAQ;SPHK2;MAPK10;PPP2R3A;PPP2R5D |
| Phospholipase D signaling pathway | PLCB2;CYTH4;DNM3;DGKE;MAPK3;KIT;PPAP2C;SHC3;PLA2G4C |
| mTOR signaling pathway | PIK3R2;PRKCBA;RHEB;PIK3CB;RPS6KA3B;PTEN;RPS6KB2;STRADA;EIF4E2RS1 |
| PIK-Akt signaling pathway | TNC;PPP2R2D;COL24A1;G6PC2;MCL1;PPP2R3C;BCL2;VEGFA;CREB5 |
| AMPK signaling pathway | PPP2R3A;CREB3L1;PIK3CA;PPP2R5C;PPP2R5B;IGF1;IRS1;CREB1;PIK3CG |
| Apoptosis | BIRC3;BAD;CTNNB2;DIABLOA;HIST1H1E;AKT1;BIRC2;RELA;PPP3CB |
| Adrenergic signaling in cardiomyocytes | PRKACB;ATP1A3;RYR2;PPP2R5D;CACNB4A;PPP2R5EB;CACNB2A;CACNB2;PPP2R5C |
| VEGF signaling pathway | NRAS;RAC1;AKT2L;MAPK12B;MAPKAPK3;RAC3A;PIK3CG;MAPK1;CASP9 |
| Osteoclast differentiation | SOCS3;CALCR;SIRP-BETA;NOX3;MAP3K14;PIK3R5;NFKBIA;TGFB2;BLNK |
| Focal adhesion | BCAR1;PIK3CB;ITGB3B;AKT3A;PIK3R3B;RAP1AA;ROCK2;CCND1;PDGFAA |
| Signaling pathways regulating pluripotency of stem cells | WNT8B;INHBA;PCGF5;APC;INHBC;ESRRB;BMPR1A;ACVR2B;MAP2K2 |
| Platelet activation | PLA2G4C;FCGR2A;ARHGAP35;FERMT3;LYN;PIK3CG;ITPR1;PIK3CA;PLCB3 |
| Toll-like receptor signaling pathway | IFNB;MAPK8B;CCL3;IFNA2;IL8L2;PIK3R3;TLR2;MAPK1;IFNA7 |
| Jak-STAT signaling pathway | IL7R;IL4R;STAT5B;Il4ra;CRFB2;IL23;IFNA13;MYCB;IL9R |
| Natural killer cell mediated cytotoxicity | VAV1;ICAM2;PPP3CA;PLCG1;PPP3CC;ULBP1;SHC1;SHC4;KIR3DL2 |
| T cell receptor signaling pathway | Il2;IKBKB;PAK6;MAP3K14;PIK3CD;CD3E;MAPK12;FOS;VAV1 |
| B cell receptor signaling pathway | CSK;PPP3CC;LIME1;CDK6;PDK2B;BCL2L11;PPP3CB;SLA2;GSK3B |
| Fc epsilon RI signaling pathway | MAPK9;MAP2K7;PDPK1;IL4;MAP2K1;PLA2G4A;GM-CSF;MAPK12;MAP2K2 |
| Fc gamma R-mediated phagocytosis | MAP2K1;PLCG2;MAPK3;PTPRC;FCGR2B;RPS6KB2;ASAP3;PPAP2B;PRKCD |
| TNF signaling pathway | PIK3R5;RPS6KA4;MAP2K4;PIK3R3;IKBKB;CFLAR;TRAF1;IL18R1;IL15 |
| Leukocyte transendothelial migration | ROCK1;MAPK12;RAC1;TXK;RAP1A;PXN;PIK3R3;ICAM1;AASS |
| Neurotrophin signaling pathway | CALML3;ARHGDIA;FASLG;TRAF6;PIK3R3;AKT2;PIK3CA;PIK3CB;IRAK1 |
| Cholinergic synapse | KCNJ2;CHRM2;CHRM1;AKT2;GNG12;GNB3;KCNQ1;GNG3;PRKCG |
| Inflammatory mediator regulation of TRP channels | PRKCD;ACCN5;PRKACB;PLCG2;PLCB1;MAPK8;CALM3;PPP1CB;PLA2G4A |
| Regulation of actin cytoskeleton | MRAS;IQGAP3;PTK2AA;ABI2;MYL7;ITGA6;DIAPH3;CDC42L;FGF3 |
| Insulin signaling pathway | HRASB;TSC2;INSRA;PYGMA;PPP1R3D;PRKAA2;CALM4;AKT1;PRKAG3B |
| Progesterone-mediated oocyte maturation | BRAF;ANAPC4;RPS6KA1;CPEB1B;GNAI2;ANAPC7;CCNB3;PKMYT1;PPP1R2P9 |
| Estrogen signaling pathway | ESR1;CALM2;HSP90AA1;GABBR1;PIK3R5;MAPK1;HSP90B1;CREB3L3;AKT1 |
| Prolactin signaling pathway | KRAS;SHC4;GSK3B;PPIB;STAT3;PIK3CB;INS1;SOS1;SRC |
| Thyroid hormone signaling pathway | PRKACA;ESR1;TSC2;MED12;ATP1A2;NCOA1;RXRA;PRKACG;NOTCH3 |
| Oxytocin signaling pathway | CAMK2D;CACNA2D4;CALM2;PRKACB;PIK3CD;ITPR1;MYL6;ACTG1;GUCY1A3 |
| Regulation of lipolysis in adipocytes | AQP7;PIK3R1;INS;PTGS1;AKT2;Adcy4;PRKACA;IRS4;NPY |
| Type II diabetes mellitus | INS-IGF2;SOCS1;TNF;PIK3R1;INSR;PIK3CB;PIK3CG;PRKCD;SOCS3 |
| Insulin resistance | RPS6KA3B;MGEA5;INS2;PTPN11B;AKT2L;PCK2;IL6;PIK3CB;PPP1R3CB |
| Non-alcoholic fatty liver disease (NAFLD) | DDIT3;NDUFC2;NDUFC1;NDUFB5;NFKB1;COX7A1;COX4I2;NDUFS3;PIK3R2 |
| Aldosterone-regulated sodium reabsorption | PRKCG;KCNJ1;IGF1;PIK3CB;HSD11B2;PIK3CD;SLC9A3R2;ALPHA-ENAC;KRAS |
| Carbohydrate digestion and absorption | Amy1;G6PC3;TAS1R2;TAS1R3;AMY2B;ATP1A2;AMY2A4;HK3;AKT1 |
| Bacterial invasion of epithelial cells | ARPC4;SHC1;SHC4;DNM1;SEPT11;WASL;VCL;GAB1;WASF2 |
| Chagas disease (American trypanosomiasis) | CD3E; CD3D;C1QC;TLR6;TGFBR2;ACE;TNFRSF1A;IL12A;GNA11;MAP2K4 |
| Toxoplasmosis | IRAK1;GNAI1;LAMA1;PDPK1;MAPK8;TYK2;MAPK3;LAMA4;MAP2K6 |
| Amoebiasis | SERPINB1B;RAB7B;PIK3R3;ACTN2;COL1A2;LAMB4;ACTN3;CD1D;C8A |
| Hepatitis C | EIF3E;IFNA2;PDPK1;PIK3CA;AKT1;CLDN14;DDX58;MAPK3;IRF1 |
| Hepatitis B | EGR3;IFNA10;CREB3L2;TGFBR1;NFATC1;AKT1;CCND1;CREB5;MAP3K1 |
| Measles | IFNA21;EIF2AK4;TP73;SLAMF1;CD46;IFIH1;cgr2b;IRAK4;PIK3R5 |
| Influenza A | MAPK11;PIK3R2;TMPRSS4;HLA-DRA;PABPN1;NXT1;NUP98;IFNA1;MAP2K1 |
| HTLV-I infection | CDC27;POLE;VDAC3;PDGFRB;WNT7B;TP53;NFYB;MAP3K1;FZD9 |
| Epstein-Barr virus infection | SND1;MAPK11;POLR3G;HSPA6;GTF2E1;PTMA;RBPJ;PSMD12;HLA-DQA2 |
| Pathways in cancer | MMP2;DAPK2;MLH1;CDH1;COL4A1;FZD7;WNT16;CBL;PTGER4 |
| Viral carcinogenesis | PIK3R3;ACTN1;SCRIB;HDAC11;BAD;CCNA1;SRF;HIST1H2BD;GRB2 |
| Proteoglycans in cancer | HOXD10;GPC1;TIMP3;PRKCA;TLR4;BRAF;ANK2;AKT2;DDX5 |
| Colorectal cancer | RAC1;PIK3R3;PIK3R1;SMAD3;BAD;BAX;TRP53;TGFBR1;MAPK10 |
| Renal cell carcinoma | TGFB3;FLCN;ARNT2;MET;RAP1A;GAB1;TCEB2;VEGFA;FH1 |
| Pancreatic cancer | RAF1;SMAD4;PIK3CB;STAT3;MAPK1;TGFB1;RB1;TGFB2;PIK3CD |
| Endometrial cancer | APC2;TP53;BRAF;AXIN2;PDPK1;FOXO3;LEF1;AKT1;MLH1 |
| Glioma | PIK3R1;PIK3CG;AKT2;PIK3R5;HRAS;MTOR;MAPK3;SOS1;CALM4 |
| Prostate cancer | HSP90AB1;MAP4K1;GSK3B;SPRY1;BRAF;PIK3R2;PDGFB;MTOR;NFKB1 |
| Melanoma | Pdgfa&Pdgfb;IGF1;RB1;MET;PIK3CB;FGF19;PIK3R2;PDGFB;KRAS |
| Chronic myeloid leukemia | SOS1;HRAS;BCL2L1;SHC1;CTBP1;RB1;AKT1;PIK3R2;PTPN11 |
| Acute myeloid leukemia | RARA;PIK3R1;PIK3CG;ZBTB16;MAPK3;TCF7L2;KRAS;PIK3CA;ARAF |
| Small cell lung cancer | NOS2;BIRC2;CKS2;PIK3CA;ITGAV;RXRG;LAMB1;NFKBIA;TRAF4 |
| Non-small cell lung cancer | FOXO3;PRKCG;AKT1;GRB2;EML4;RXRA;PLCG2;PIK3R3;RAF1 |
| Central carbon metabolism in cancer | PKM;HIF1A;GLS2;PIK3R1;SLC16A3;TP53;HK1;C12orf5;NTRK1 |
| Choline metabolism in cancer | TAE1;PLA2G4C;DGKD;PLA2G4B;Pdgfa&Pdgfb;CHKB;SP1;PDGFRB;PDGFC |
PIK3CG has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CG itself. We selected most functions PIK3CG had, and list some proteins which have the same functions with PIK3CG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3C3;PIK3R3;PIK3CD;PIK3CB;ATM;PIK3C2G;PIK3C2A;PIK3CG;PIK3CA |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3C2B;PIK3CB;PIK3CD;PIK3CA;PIK3CG;PIK3C2G;PIK3C2A |
| ATP binding | PRKCI;PKZ;DDX4;DDX54;NTPCR;TNIKB;MYO1F;KIF19;RARS |
| ephrin receptor binding | EFNA1A;PIK3CG;CHN1;EFNA5B;CDK5R1;EFNB2;CDK5;SHC1;EFNB2B |
| phosphatidylinositol 3-kinase activity | PIK3C2A;PIK3CD;PIK3CB;PIK3CG;PIK3CA |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | PIK3CG;PIK3CD;PIK3CB;PIK3CA |
| protein binding | PIDD1;RALBP1;PPP2R5A;C17orf59;MYO18A;GYPB;MLLT10;SPANXC;VSNL1 |
| protein kinase activity | PIK3CG;GSK3AB;PRKCHA;JAK2;AURKA;PKN3;PDK4;MAP4K6;STK25A |
| protein serine/threonine kinase activity | FAM20C;DCKL1B;IRAK2;ADCK4;MAPKAPK5;PRPF4B;UHMK1;GM711;IRAK3 |
PIK3CG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CG here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CG.
PIK3R5; PDE3B; HRAS; KIT; CD37; BCR; UTRN; PRKAA2; USP45; PIK3R5; GABARAPL1; PRMT7
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