pik3cg
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  • Official Full Name
  • phosphoinositide-3-kinase, catalytic, gamma polypeptide
  • Background
  • This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
  • Synonyms
  • PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; p110gamma; p120-PI3K; PI3K-gamma; p110-gamma; PI3-kinase subunit gamma; ptdIns-3-kinase subunit gamma; 1-phosp
Cat.#:PIK3CG-158HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CG protein, His-tagged, Active
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Cat.#:PIK3CG-29586THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIK3CG
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Cat.#:PIK3CG-31759THTag:N/A
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CG & PIK3R5 protein
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Cat.#:PIK3CG-524HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PIK3CG
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Cat.#:PIK3CG-53HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CG, His-tagged
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Cat.#:PIK3CG-55HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CG, GST-tagged
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Cat.#:PIK3CG-3433RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3CG Protein, His-tagged
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Cat.#:PIK3CG-4372CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CG
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Cat.#:PIK3CG-12494ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3CG
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Cat.#:PIK3CG-1080HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-Kinase, Catalytic, His-tagged
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Cat.#:PIK3CG-3186HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIK3CG 293 Cell Lysate
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Involved Pathway

PIK3CG involved in several pathways and played different roles in them. We selected most pathways PIK3CG participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PLCD1A; IPMKB; INPP4A; NUDT10; ITPKA; INPP5B; PIP4K2C; NUDT11; MTMR4; PIP5K1B
ErbB signaling pathway
ELK1; PRKCA; MAPK8; GSK3AA; CAMK2D; SHC3; PTK2AA; PIK3R3A; PAK6; BRAF
Ras signaling pathway
LAT; KIT; PDGFRB; EFNA4; Pdgfa&Pdgfb; PGF; PLD1; IGF1; IGF1R; ZAP70
Rap signaling pathway
PRKCB; GRIN2A; FYB; PIK3R2; FGF5; PLCB4; LCP2; F2RL3; GNAI3; INSR
cGMP-PKG signaling pathway
PPIF; INS2; VDAC2; ATP1A4; PIK3CB; GNAI1; MYLK3; AKT2; RHOA; GUCY1B3
cAMP signaling pathway
CNGA4; TSHR; PLN; CNGA2; GRIN3B; ATP1B3; FSHR; NFATC1; VIPR2; ROCK2
Chemokine signaling pathway
CDC42; CCL20; GNGT1; GRK7; CXCR1; Adcy4; XCL1; Ccl21c; PRKCZ; GM13304
HIF- signaling pathway
ANGPT4; RELA; CAMK2D; PIK3CG; HK2; NPPA; BCL2; Trf; PLCG2; PDHA1
FoxO signaling pathway
FOXO3A; IL7R; MAPK8B; CDKN2D; CCNB3; CCND2A; TGFB3; BCL6A; FOXO3; ARAF
Phosphatidylinositol signaling system
PPIP5K1; IPMK; PIP4K2B; INPP4A; PIK3R3A; IPMKB; PLCE1; CALM2; INPPL1; CALM1A
Sphingolipid signaling pathway
SMPD2; SGMS2; PPP2CA; S1PR5; SPTLC1; LASS2; FCER1G; AKT2; S1PR4; PRKCZ
Phospholipase D signaling pathway
PIK3R3; SHC1; GRM7; LPAR5; SOS1; PLCB2; LPAR2; CYTH4; RAF1; AGTR1A
mTOR signaling pathway
RICTOR; RPS6KA2; RPS6KA6; AKT1; EIF4E2RS1; RPS6KB1B; RPS6KAL; RPS6KB2; VEGFAB; TSC1A
PIK-Akt signaling pathway
OSMR; BCL2L1; IFNA7; TSC2; ITGA1; GNG10; ITGA4; GNG8; ANGPT2; IFNA17
AMPK signaling pathway
G6PC3; PPP2R5D; PPP2R5E; HMGCR; CD36; PPP2R5B; SCD5; TBC1D1; PFKFB4; PFKFB2
Apoptosis
CAPN2A; IRAK1; IL3RA; DAPK3; NGF; HIST1H1E; BADB; RIPK1; DSG3; BIRC5A
Adrenergic signaling in cardiomyocytes
CACNG6A; ATP1A1; CACNG4; CACNB3; MYL3; ADRB2B; GNAQ; PLCB3; PPP2R5CB; BCL2
VEGF signaling pathway
AKT2; PIK3R3A; SPHK2; MAPKAPK3; PRKCA; HSPB1; RAF1B; RAC1; NFATC2; PLA2G4A
Osteoclast differentiation
PIK3R3; CYBB; IL1B; FCGR1; IFNAR2; FOS; MAPK13; LILRA3; LILRB4; SYK
Focal adhesion
PDGFD; RHOAC; MYLK3; COL27A1; RAF1A; COL6A1; RHOA; ITGA2; HRASA; FN1
Signaling pathways regulating pluripotency of stem cells
FGFR4; SMAD5; MAP2K2; PIK3CD; WNT16; HESX1; SMAD1; BMPR1A; ACVR1C; NANOG
Platelet activation
PIK3CD; PRKACG; ACTB; PRKG1; GP1BB; ARHGAP35; COL27A1; MAPK1; PTGIR; PLA2G4F
Toll-like receptor signaling pathway
TLR5; IFNA1; MAPK8A; SPP1; MAPK13; IRAK1; MAPK14A; CCL3L1; MAPK9; IRF3
Jak-STAT signaling pathway
SOS1; PIK3R3A; IFNG1-2; PIM1; CRFB4; IFNK; IL13; IL2RGB; IL22RA1; IFNA14
Natural killer cell mediated cytotoxicity
IFNA12; KIR2DL1; SH3BP2; PTK2B; ITGB2; CD244; RAET1D; NFATC2; CD48; HLA-A
T cell receptor signaling pathway
MAP2K2; PPP3R1; CD8B1; MAPK13; VAV2; BCL10; CBLB; CD247; PAK1; NFATC1
B cell receptor signaling pathway
BANK1; CD19; STAP1; CDK4; IKBKG; RASGRP3; ARPC1B; CR2; NFATC1; BCL10
Fc epsilon RI signaling pathway
TNF; PIK3CB; MAPK8; IL3; FYN; PLA2G4A; IL5; GAB2; MAPK13; PLCG2
Fc gamma R-mediated phagocytosis
CFL2; PPAP2A; PIK3R2; PLD2; PPAP2C; BIN1; MAPK1; PIK3R1; VASP; cgr2b
TNF signaling pathway
BIRC2; MMP3; AKT2; CCL20; MAGI2; CXCL3; CREB3L1; TAB2; IL18R1; FADD
Leukocyte transendothelial migration
PECAM1; PIK3R1; CLDN17; PIK3R3; MYL2; CYBA; JAM2; MMP9; CXCL12; VCL
Neurotrophin signaling pathway
MAP3K5; TP73; MAPK1; AKT2; ATF4; PIK3CB; KRAS; IRAK4; CAMK2B; PIK3R5
Cholinergic synapse
FYN; GNG5; PIK3R1; PIK3CG; KCNJ14; PLCB1; GNG7; JAK2; KCNJ12; GNAI2
Inflammatory mediator regulation of TRP channels
PTGER4; PRKACB; CYP2C37; TRPM8; BDKRB1; PPP1CA; CYP2C55; CALML5; PPP1CB; PLA2G6
Regulation of actin cytoskeleton
ARPC5LA; PAK6B; RAC2; ARPC5B; ITGA3; PTK2AA; FGFR4; FGF18A; PIKFYVE; RRAS2
Insulin signaling pathway
PIK3R3; PPP1R3DA; FASN; MAPK8B; FBP1A; BAD; PRKAB2; PRKACAB; EXOC7; PTPRF
Progesterone-mediated oocyte maturation
BRAF; ADCY1A; MAD2L2; ARAF; GNAI3; CCNB1; HSP90AA1.1; ANAPC5; HSP90AB1; MAPK12B
Estrogen signaling pathway
PIK3CD; GNAS; GABBR2; PRKCD; MAP2K1; NOS3; CREB3L2; PLCB4; KRAS; PRKACB
Prolactin signaling pathway
STAT3; STAT5B; PIK3CG; PIK3CD; MAPK9; SRC; PPIB; PIK3R3; INS2; SOCS7
Thyroid hormone signaling pathway
CCND1; ATP1A2; SLC16A2; PLCG2; ITGB3; KAT2A; SLC2A1; HDAC2; PLCE1; NOTCH4
Oxytocin signaling pathway
CAMK2B; MYL9; TRPM2; GNAO1; PRKAG1; PRKCB; ACTB; OXT; PLA2G4C; MAP2K5
Regulation of lipolysis in adipocytes
LIPE; INS1; AQP7; PIK3CG; INSR; NPY; PTGS2; LOC100328615; PRKACG; GNAI2
Type II diabetes mellitus
INS1; TNF; MTOR; INS; SOCS1; PKM; INS2; SOCS4; PIK3R5; PRKCE
Insulin resistance
RPS6KA3B; PRKAG1; MAPK8B; IL6; INS; PTPN11; PRKCB; MAPK10; AKT2; SLC27A4
Non-alcoholic fatty liver disease (NAFLD)
BID; GSK3A; NFKB1; UQCRB; NDUFB10; IL1B; NDUFC1; FAS; NDUFV2; IRS2
Aldosterone-regulated sodium reabsorption
INS; PIK3CG; PDPK1; NEDD4L; MAPK1; PIK3R5; SGK1; PRKCA; HSD11B2; SCNN1G
Carbohydrate digestion and absorption
ATP1B3; AMY2B; AKT1; AMY1A; SLC5A1; TAS1R2; PIK3R1; FXYD2; PLCB2; PIK3CA
Bacterial invasion of epithelial cells
SEPT6; ILK; ARPC1A; ARPC5L; ELMO2; CAV3; GAB1; MET; ARPC2; RHOA
Chagas disease (American trypanosomiasis)
PLCB2; TGFB3; MAP2K4; GNAQ; BDKRB2; TGFB2; CASP8; PIK3R3; IFNB1; FOS
Toxoplasmosis
BIRC7; PIK3CD; BIRC8; PIK3CA; HLA-DMB; PIK3R2; PIK3CG; CD40LG; LDLR; TNF
Amoebiasis
SERPINB13; COL5A1; ACTN3; C8B; COL4A1; RELA; LAMC1; PLCB3; LAMB2; PIK3R2
Hepatitis C
IFNA1; PPP2R2D; MAPK9; PPP2R2A; DDX58; NFKBIA; EIF2AK3; IFNAR2; IKBKG; MAPK10
Hepatitis B
ELK1; CYCS; PRKCA; TGFB1; IFNA17; CCNE1; BAD; EGR2; TGFBR1; IFNA4
Measles
HSPA8; PIK3CD; TBK1; IFNA13; TP53; IFNA4; IL2RB; NFKBIA; TNFRSF10A; CCND3
Influenza A
LOC780933; VDAC1; GSK3B; MAP2K3; Ccl12; NXT2; EIF2AK3; IFNA8; PIK3CG; PIK3R2
HTLV-I infection
HLA-E; FZD8; HLA-DPA1; ANAPC11; ATF1; HLA-DRA; PPP3CA; RELB; CD3E; IL2RB
Epstein-Barr virus infection
XPO1; YWHAH; HLA-DRB1; PLCG2; POLR1D; PSMC1; TNFAIP3; LYN; HSPA8; RBPJ
Pathways in cancer
CTNNA3; TRAF6; ARHGEF12; PIK3R2; GNB2; GNA11; F2R; WNT8A; WNT3; LAMB1
Viral carcinogenesis
UBR4; H2BFWT; HLA-C; STAT5A; HIST1H4D; SCRIB; HIST1H4N; CCNA2; EGR3; YWHAB
Proteoglycans in cancer
IL12B; PTPN11; IGF1; PLCG1; MTOR; RHOA; WNT7B; CTTN; PTCH1; RAC1
Colorectal cancer
RAC1; AXIN2; PIK3R5; BIRC5; TCF7; TGFBR2; RALGDS; MSH6; BRAF; RAC3
Renal cell carcinoma
TGFB2; KRAS; BRAF; CUL2; FH1; NRAS; PDGFB; PAK7; RAF1; ETS1
Pancreatic cancer
MAP2K1; CCND1; RAF1; STAT3; TGFBR1; BAD; KRAS; BCL2L1; MAPK1; SMAD4
Endometrial cancer
PIK3CA; CDH1; MAP2K2; TCF7L2; BRAF; CTNNA3; PIK3R2; APC2; TRP53; PDPK1
Glioma
PRKCB; CALM4; MAP2K1; TRP53; PIK3R5; PIK3CA; PLCG1; PDGFRA; SHC3; HRAS
Prostate cancer
CREB3L2; MDM2; SPRY1; ATF4; NKX3; PDGFD; HSP90B1; NDRG1; GSTP1; TGFA
Melanoma
FGF4; FGF17; PIK3R1; Pdgfa&Pdgfb; FGF5; CDH1; IGF1; MET; BAD; NRAS
Chronic myeloid leukemia
SHC2; MAPK3; SOS1; MAPK1; BRAF; PIK3R3; SMAD4; MAP2K1; BCR; STAT5B
Acute myeloid leukemia
JUP; BAD; KIT; CHUK; MAPK3; FLT3; STAT3; AKT1; PIK3R3; SFPI1
Small cell lung cancer
XIAP; LAMC1; RXRG; IKBKB; PIK3CA; ITGA6; BCL2; PTGS2; TRAF6; PIAS2
Non-small cell lung cancer
HRAS; STK4; RARB; SOS1; BRAF; MAP2K2; PIK3CG; RASSF1; PRKCG; ALK
Central carbon metabolism in cancer
LDHA; RAF1; MTOR; PGAM2; PFKL; IDH1; PIK3R1; GLS; PGAM1; SLC2A1
Choline metabolism in cancer
WASL; PDGFA; LYPLA1; NRAS; PIP5K1C; SLC22A1; EIF4EBP1; PLD1; PDPK1; Pdgfa&Pdgfb

Protein Function

PIK3CG has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CG itself. We selected most functions PIK3CG had, and list some proteins which have the same functions with PIK3CG. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein ATM; PIK3C2A; PIK3CD; PIK3CB; PIK3C2G; PIK3C3; PIK3R3; PIK3CA; PIK3C2B; PIK3CG
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3C2A; PIK3C2B; PIK3CA; PIK3C2G; PIK3CB; PIK3CG; PIK3CD
Function ATP binding
Related Protein SMYHC2; AK7B; FGFR2; XRCC5; MAPK14A; MAPK7; MSH3; BCR; ATP13A1; TOP2B
Function ephrin receptor binding
Related Protein SIPA1L1; EFNB3; CDK5R1; EFNB2A; GRB2; EPHA7; EFNA4; SRC; EFNA1B; EFNA3B
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CG; PIK3CB; PIK3C2A; PIK3CD; PIK3CA
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CA; PIK3CG; PIK3CB; PIK3CD
Function protein binding
Related Protein PTEN; CSNK1G1; POLR1C; CUBN; XPO6; SH3RF2; NUP107; TPR; S100A4; GLUD1
Function protein kinase activity
Related Protein RIPK4; RPS6KA5; INSRA; CDK13; CSNK1A1; TEX14; CDKL2; EEF2K; GM4922; STK38A
Function protein serine/threonine kinase activity
Related Protein TTN; PBK; AKT2; ULK1; STK40; LATS2; STK35L; PRPF4B; CAMKK1B; ROCK2

Interacting Protein

PIK3CG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CG here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CG.
PIK3R5; PDE3B; HRAS; KIT; CD37; BCR; UTRN; PRKAA2; USP45; PIK3R5; GABARAPL1; PRMT7