|Official Full Name||cAMP-dependent protein kinase 1|
|Background||cAMP-dependent PKA is an ubiquitous serine/threonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catalytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits suggest specific functions.|
|Synonyms||PKACa; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha,isoform 1; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha|
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PKAc-a involved in several pathways and played different roles in them. We selected most pathways PKAc-a participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PKAc-a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
PKAc-a has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PKAc-a itself. We selected most functions PKAc-a had, and list some proteins which have the same functions with PKAc-a. You can find most of the proteins on our site.
PKAc-a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKAc-a here. Most of them are supplied by our site. Hope this information will be useful for your research of PKAc-a.