PKAc-a Protein, cAMP-dependent protein kinase 1


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Official Full Name cAMP-dependent protein kinase 1
Background cAMP-dependent PKA is an ubiquitous serine/threonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catalytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits suggest specific functions.
Synonyms PKACa; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha,isoform 1; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
    • Species :
    • Source :
    • E.coli
    • Tag :
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    PKAc-a-92 Recombinant cAMP-Dependent Protein Kinase A catalytic subunit α E.coli N/A

    PKAc-a involved in several pathways and played different roles in them. We selected most pathways PKAc-a participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PKAc-a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PKAc-a has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PKAc-a itself. We selected most functions PKAc-a had, and list some proteins which have the same functions with PKAc-a. You can find most of the proteins on our site.

    Function Related Protein

    PKAc-a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKAc-a here. Most of them are supplied by our site. Hope this information will be useful for your research of PKAc-a.

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