pkd1
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  • Official Full Name
  • polycystic kidney disease 1 (autosomal dominant)
  • Background
  • This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
  • Synonyms
  • PKD1; polycystic kidney disease 1 (autosomal dominant); polycystin-1; PBP; Pc 1; polycystin 1; transient receptor potential cation channel; subfamily P; member 1; TRPP1; Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease protein 1; OTTHUMP00000208669; OTTHUMP00000208670; Pc-1; PKD; PKD1_HUMAN; Polycystic Kidney Disease 1; polycystic kidney disease-associated protein; Polycystin 1 Precursor; transient receptor potential cation channel, subfamily P, member 1
Cat.#:PKD1-12857MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PKD1 Protein
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Involved Pathway

PKD1 involved in several pathways and played different roles in them. We selected most pathways PKD1 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
CKAP5; DCTN2; TTC8; CLASP1; B9D1; TRIP11; KIF3C; TSGA14; WDR19; BBS5
Cargo trafficking to the periciliary membrane
BBS2; ARL3; CCT5; CCT3; ARF4; CYS1; SETD6; ARL13B; NPHP3; SSTR3
Organelle biogenesis and maintenance
MRPS34; GABPB1; BBS1; IFT88; TTBK2; IFT43; IFT46; WDR19; TRAF3IP1; MRPL41
VxPx cargo-targeting to cilium
PKD2; ARF4; PKD1; CNGA5; CNGA2; ARF4A; RAB3IP
XPodNet - protein-protein interactions in the podocyte expanded by STRING
CDC42EP5; GAB3; Ighg; ZFP423; DDN; FRAS1; SNTB1; TENC1; MTAP1A; PKD1

Protein Function

PKD1 has several biochemical functions, for example, calcium channel activity, carbohydrate binding, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD1 itself. We selected most functions PKD1 had, and list some proteins which have the same functions with PKD1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein GPM6A; CACNA1BA; CHRNA9; TRPV6; GRIN2B; RYR1B; TRPV1; CHRNA10; CACNA1DA; PKD2L1
Function carbohydrate binding
Related Protein SIGLEC7; CD22; OLR1; GALNT12; CD34; GALNT3; SIGLEC11; MAG; GALNTL1; ASGR2
Function cation channel activity
Related Protein GAR1; ASIC1A; FAM38A; PKD2L1; TRPM1B; ASIC3; TRPM1; CALHM3; ASIC4A; MCOLN1
Function ion channel binding
Related Protein KCNE4; PKD1; KCNQ1; S100A10; ACTN1; PACS2; DIAP1; GRINA; CTNNB1; BAK1
Function protein binding
Related Protein OTX1; C1QTNF8; FNBP1; EIF4E; RASSF3; DHH; HJURP; SF3B3; CAB39L; CASP6
Function protein domain specific binding
Related Protein DDC; LIN7B; LIN7C; HGS; HIST1H4E; SHC4; TNNI3; KCTD13; TADA3; STAMBP
Function protein kinase binding
Related Protein MAPT; CDK5RAP1; DVL1; GRIN2A; HDAC7; E2F1; RB1CC1; PGAM1; AKAP7; ACVRL1

Interacting Protein

PKD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD1.
SF1; Pkd2; Id2; ACTB; PDK2; Actb; CTTN

PKD1 Related Articles

Lian, PW; Li, A; et al. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development. PLOS ONE 9:-(2014).
Vijayakumar, S; Dang, S; et al. Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 306:F640-F654(2014).