pla2g2e
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  • Official Full Name
  • phospholipase A2, group IIE
  • Background
  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
  • Synonyms
  • PLA2G2E; phospholipase A2, group IIE; group IIE secretory phospholipase A2; 2IIE; EC 3.1.1.4; GIIE sPLA2; Group IIE secretory phospholipase A2 precursor; Phosphatidylcholine 2 acylhydrolase GIIE; Phosphatidylcholine 2-acylhydrolase 2E; Phospholipase A2 group IIE; sPLA; sPLA2-IIE
Cat.#:PLA2G2E-69HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phospholipase A2, Group IIE, His-tagged
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Cat.#:Pla2g2e -1196MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pla2g2e protein, His-tagged
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Cat.#:Pla2g2e-1196MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pla2g2e, His-tagged
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Cat.#:PLA2G2E-4101CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G2E
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Cat.#:PLA2G2E-1874MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PLA2G2E cell lysate
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Involved Pathway

PLA2G2E involved in several pathways and played different roles in them. We selected most pathways PLA2G2E participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
PTDSS1; PHYKPL; PLA2G4A; LYPLA2; ETNK2; ETNK1; PCYT1BB; AGPAT5; PTDSS2; ETNPPL
Ether lipid metabolism
PLA2G2E; PLA2G12A; PLA2G2D; CEPT1; LPCAT4; CEPT1B; PLD1A; PLD3; PPAP2A; PLA2G4B
Arachidonic acid metabolism
GPX3; FAM213B; CYP4F18; PLA2G2A; CYP4A11; ALOX15; CBR3; CBR1; ALOX15B; PLA2G4D
Linoleic acid metabolism
CYP2C70; CYP3A65; PLA2G4C; PLA2G2E; PLA2G1B; PLA2G6; CYP2J2; PLB1; CYP2C50; CYP2C19
alpha-Linolenic acid metabolism
PLA2G2F; PLA2G6; PLA2G5; PLA2G2D; PLA2G10; PLA2G4A; PLA2G4AA; PLA2G12A; PLA2G2A; PLA2G2E
Metabolic pathways
PLA2G2A; GUK1A; IMPA1; CYCS; ACSL4; UQCRH; DAK; PLA2G12B; UGP2A; H2-KE6
Ras signaling pathway
PLA2G2D; RRAS2; VEGFB; GAB2; CALM4; SHOC2; ANGPT4; FGF8; PLA2G12A; FLT1
Vascular smooth muscle contraction
PLCB4; CALM1A; AGTR1B; GNA12A; PPP1R12B; ITPR3; CALM3B; PRKACBA; GNA11; CACNA1DA
Pancreatic secretion
ATP2A3; PLA2G5; CPA3; ATP2B4; CLCA2; PRSS1; CTRB1; PLA2G2E; PLCB4; Adcy4
Fat digestion and absorption
CD36; PLA2G10; PPAP2A; PLA2G12A; MOGAT3; PLA2G2D; PLA2G2A; GOT2; ABCG8; PLA2G3

Protein Function

PLA2G2E has several biochemical functions, for example, calcium ion binding, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2E itself. We selected most functions PLA2G2E had, and list some proteins which have the same functions with PLA2G2E. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein SYT12; NOTCH1B; CAPNS1; EFCAB3; PCDH2AA15; RGN; S100V2; SLIT1A; PADI4; KCNIP1
Function phospholipase A2 activity
Related Protein OC90; RARRES3; PRDX6; PLA2G1B; PLA2G2F; PLA2G4A; PNPLA3; PLA2G12B; PLA2G2D; ABHD3

PLA2G2E Related Articles

Yamaguchi, K; Chijiwa, T; et al. The Finding of a Group IIE Phospholipase A(2) Gene in a Specified Segment of Protobothrops flavoviridis Genome and Its Possible Evolutionary Relationship to Group IIA Phospholipase A(2) Genes. TOXINS 6:3471-3487(2014).
Karray, A; Ben Ali, Y; et al. Drastic changes in the tissue-specific expression of secreted phospholipases A2 in chicken pulmonary disease. BIOCHIMIE 94:451-460(2012).